Labwork on 50MG Winstrol

[Mufasa123]

Here is the approval docs from the FDA, take a look at clinical pharmacology review Part 1

Drug Approval Package: Zetia (ezetimibe) NDA #21445

Here's the underlying trial used for the FDA application.

https://doi.org/10.1016/S1520-765X(01)90107-5

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16% reduction at 5mg vs 19% reduction at 20mg. Hard to believe how effective even 0.25mg is. For example, with an LDL of 100, there is only a ~3 point reduction between 5 and 10mg of ezetimibe. I don't have a prescription and don't want any cholesterol drugs on my medical history right now, so I will stick with 5mg per day.

Classic law of diminishing returns. Amazing what 0.25mg does and using 40x that amount (10mg...if my math is right) is only 2x the result.

 

[BBSQ5]

It’s all a crap shoot on what will work for you and what your body will respond to while on or off orals.

Everyone have some good advice on supps., meds, etc. that may help.

Zetia
Niacin
Omega-3’s
Glutathione Injections
TUDCA
And many more mentioned.

I too, love Winny, but it does same thing to me now at 48 and always did when I was younger. Good luck and stopping now after the 4 weeks you just did to take a break and let all regulate out.

 

[Duke309]

Classic law of diminishing returns. Amazing what 0.25mg does and using 40x that amount (10mg...if my math is right) is only 2x the result.

There are similar charts for all the statins too. Huge drop off in effectiveness of rosuvastatin after 10mg for example

 

[pesty4077]

There are similar charts for all the statins too. Huge drop off in effectiveness of rosuvastatin after 10mg for example

10 mg of Ezetimibe will drop my LDL a lot more then those charts show.

 

[traininsane11]

My lipids (hdl, ldl etc) are a little out of whack post prep and I’m gonna try and fix them using none medical stuff so

High dose citrus bergamot (1.5-2g)
Red yeast extract 600mg
Grapeseed extract 1g
Coq 10 600mg
3G omega 3 with 600mg EPA & 300mg DHA per 1g
Cardio 5x 25 mins and 8-10k steps
Super clean diet


If all that fails I’ve got some pravastatin 10mg that I’m very reluctant to use

 

[pesty4077]

My lipids (hdl, ldl etc) are a little out of whack post prep and I’m gonna try and fix them using none medical stuff so

High dose citrus bergamot (1.5-2g)
Red yeast extract 600mg
Grapeseed extract 1g
Coq 10 600mg
3G omega 3 with 600mg EPA & 300mg DHA per 1g
Cardio 5x 25 mins and 8-10k steps
Super clean diet


If all that fails I’ve got some pravastatin 10mg that I’m very reluctant to use

I think that is a good approach. Keep us updated how it works for you.

 

[traininsane11]

I think that is a good approach. Keep us updated how it works for you.

Thanks mate will do really hope I can get the numbers in a good spot and keep them there without needing to use pharma meds but we shall see I believe @bbxtreme has managed to do this or something similar so that’s promising

 

[Duke309]

10 mg of Ezetimibe will drop my LDL a lot more then those charts show.

It varies by person, my mother gets very little reduction from ezetimibe.

 

[Duke309]

My lipids (hdl, ldl etc) are a little out of whack post prep and I’m gonna try and fix them using none medical stuff so

High dose citrus bergamot (1.5-2g)
Red yeast extract 600mg
Grapeseed extract 1g
Coq 10 600mg
3G omega 3 with 600mg EPA & 300mg DHA per 1g
Cardio 5x 25 mins and 8-10k steps
Super clean diet


If all that fails I’ve got some pravastatin 10mg that I’m very reluctant to use

If your red yeast rice extract actually contains the active ingredient, it is actually a station. It's what the first statins were based off of. You might as well take pitavastatin or pravastatin. The side effects really aren't bad at low doses and reducing your LDL to less than 50 really reduces your risk of cardiovascular events.

 

[traininsane11]

If your red yeast rice extract actually contains the active ingredient, it is actually a station. It's what the first statins were based off of. You might as well take pitavastatin or pravastatin. The side effects really aren't bad at low doses and reducing your LDL to less than 50 really reduces your risk of cardiovascular events.

I went for this based off what I could find and someone on here said they had great results with it

Red Yeast Rice Extended Release

Nature's Plus Herbal Actives Red Yeast rice Extended Release tablets release red yeast rice extract over an extended period during the day. Fast Shipping

victoriahealth.com

Pravastatin is all I can get currently statin wise so if I can’t fix it with the above may add that in at 10mg see if that combined does the job

I’ve not found many guys using it on here though other than 1 think
(Using the search function) has anyone had any experiences with it?

 

[Duke309]

I went for this based off what I could find and someone on here said they had great results with it

Red Yeast Rice Extended Release

Nature's Plus Herbal Actives Red Yeast rice Extended Release tablets release red yeast rice extract over an extended period during the day. Fast Shipping

victoriahealth.com

Pravastatin is all I can get currently statin wise so if I can’t fix it with the above may add that in at 10mg see if that combined does the job

I’ve not found many guys using it on here though other than 1 think
(Using the search function) has anyone had any experiences with it?

Pravastatin is probably the next best choice if pitavastatin isn't available since it doesn't have the risk of causing insulin resistance. Here is the dose response curves for the statins that I was talking about earlier. Below is another chart which shows even more comparison of statins and their relative effectiveness. 4mg of pitavastatin is the first choice depending on how much LDL needs to come down. Second choice would be 40mg of pravastatin. Last choice would be 5mg of rosuvastatin. All of these can have 5-10mg of ezetimibe added with practically no additional side effects. If that still doesn't bring LDL down enough then add bempedoic acid, however that could potentially have a long term tendon risk.

The absolute best drugs for cholesterol are the PCSK9 inhibitors like repatha, but those are very expensive and hard to get.

 

[traininsane11]

Pravastatin is probably the next best choice if pitavastatin isn't available since it doesn't have the risk of causing insulin resistance. Here is the dose response curves for the statins that I was talking about earlier. Below is another chart which shows even more comparison of statins and their relative effectiveness. 4mg of pitavastatin is the first choice depending on how much LDL needs to come down. Second choice would be 40mg of pravastatin. Last choice would be 5mg of rosuvastatin. All of these can have 5-10mg of ezetimibe added with practically no additional side effects. If that still doesn't bring LDL down enough then add bempedoic acid, however that could potentially have a long term tendon risk.

The absolute best drugs for cholesterol are the PCSK9 inhibitors like repatha, but those are very expensive and hard to get.


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View attachment 238448

This is really informative thank you for sharing

 

[null88]

I went for this based off what I could find and someone on here said they had great results with it

Red Yeast Rice Extended Release

Nature's Plus Herbal Actives Red Yeast rice Extended Release tablets release red yeast rice extract over an extended period during the day. Fast Shipping

victoriahealth.com

Pravastatin is all I can get currently statin wise so if I can’t fix it with the above may add that in at 10mg see if that combined does the job

I’ve not found many guys using it on here though other than 1 think
(Using the search function) has anyone had any experiences with it?

A lot of doctors prescribe Pravastatin, its cheap, very available, low side effects. For me, I rather pay more and deal with side effects than have to worry about atherosclerosis

 

[traininsane11]

A lot of doctors prescribe Pravastatin, its cheap, very available, low side effects. For me, I rather pay more and deal with side effects than have to worry about atherosclerosis

I do have like 80x10mg on hand and can get more most likely and may well use them just trying to go the none medical route first but if that doesn’t work out will try adding them in at 10mg and work up if needed

 

[Siggy]

Here's a few of mine for anyone curious. I don't have much with winstrol only. Usually I was running it with tren. Given these, I don't worry too much if tren isn't in the picture.

For what it's worth, 500 test E with 600 primo yields an HDL of 21-25 (run it twice and got these) but nothing else moved from normal TRT so it's sizable HDL hit only up to that dose. Running Tren and Winny longer-term is roughly the same or just under those on my HDL.


Test E 500, Deca 200, Tren E 400, and Winstrol 350 weekly (2021 Week 10 - winstrol run the whole time)
AST 40 (normally in 20s but in range 10-40)
ALT 79 (normally in 20s, high as range is 9-46)
HDL 16 (at 35-40 on TRT low range is 40 - this is my worst reading ever actually)
LDL 72 normal
Tris 120 normal but elevated from my norm of 50-70 on lower carb diet. When eating decent carbs it goes up significantly and obviously orals and aas make it worse

Test E 500 Deca 400 Winstrol 350 Tren A 350-575 (ranged during run, probably 575) (2018 Week ~12, winstrol was added 6 weeks previous to test)
AST 42 (normally in 20s but just out of range 10-40)
ALT 48 (normally in 20s, but just out of range is 9-46)
HDL 21 (at 35-40 on TRT low range is 40 - been low my whole life)
LDL 75 normal
Tris 153 just outside 149 top of range but elevated from my norm of 50-70 on lower carb diet, was eating a good amount of carbs as I recall

Those are some nice low AST/ASL numbers while on Win. Did you use any ancillaries during that time?

 

[Mufasa123]

Those are some nice low AST/ASL numbers while on Win. Did you use any ancillaries during that time?

Nothing. Never used any of the cleanse or liver/organ assist stuff. Just me. Tren was in there too on both tests and it also will move my numbers up even alone/no winny, just usually still in range or at margin. Consistently always a nudge up though.

I didn't take time off training either for these tests though I likely got these done at 7am and didn't train at 4-5am same morning. I've never seen training make a difference for me though for medical or insurance I'll break for 3 days before.

This is just me/my enzymes. Highest I think they've ever been was on a cruise dose (no orals) but low test and likely some deca which never move them, ironically around 80s. No idea as I repeated the test 2 weeks later to ensure alcohol wasn't playing a part and even cut out my pre-workout - same reading. A few months later numbers were back in 20s and haven't seen that anomaly before/after.

 

[Siggy]

Nothing. Never used any of the cleanse or liver/organ assist stuff. Just me. Tren was in there too on both tests and it also will move my numbers up even alone/no winny, just usually still in range or at margin. Consistently always a nudge up though.

I didn't take time off training either for these tests though I likely got these done at 7am and didn't train at 4-5am same morning. I've never seen training make a difference for me though for medical or insurance I'll break for 3 days before.

This is just me/my enzymes. Highest I think they've ever been was on a cruise dose (no orals) but low test and likely some deca which never move them, ironically around 80s. No idea as I repeated the test 2 weeks later to ensure alcohol wasn't playing a part and even cut out my pre-workout - same reading. A few months later numbers were back in 20s and haven't seen that anomaly before/after.

Did you have the blood drawn before you took your daily dose of winstrol? I took my labs a couple of hours after taking the winny. Im considering getting another set of labs before taking the winny just to see how big of a difference there is , if any.

 

[nothuman]

After 3 weeks of 50MG Winstrol I decided to check my labs. I love Winny, its my favorite oral and will always use it to cut, so I figured I should see what its doing to my labwork.

I am also currently on 900mg Test E.

Keep in mind that I am also taking a robust amount of liver support which includes:

1000MG Tudca
3600MG NAC
1000MG Milk Thistle
6000MG Spirulina (great for lowering LDL)
2000mg Vit C
4000MG Astragalus



Well, that 50MG of Winstrol told me to take my robust liver support and shove it my ass.

Labwork after 3 weeks of 50mg Winstrol=

LDL 140 (Usually 113 on 900mg Test)
HDL 27 (Usually 37 on 900mg Test)
Triglycerides 166 (Usually 80 on 900mg Test)
Non HDL Cholesterol 170 (Usually 130 on 900MG Test)

Hematocrit 55 (Usually 50 on 900MG Test)

AST 76 (Usually 40)
ALT 106 (Usually 40


I was dissapointed and expecting a lower ALT and lower cholesterol numbers, considering all the ancillaries im taking.

I am considering take a statin during oral cycles now. Does anybody do this strictly on orals?

Also does anyone think Glutathione injections would lower the ALT any more than what my current support already does?

I love threads like this. Thanks for demonstrating what labs could look like when taking x compound at x dosage.

 

[Mufasa123]

Did you have the blood drawn before you took your daily dose of winstrol? I took my labs a couple of hours after taking the winny. Im considering getting another set of labs before taking the winny just to see how big of a difference there is , if any.

I can't say for 100% but I think yes. I was using 25mg caps 2x daily so morning dose with my vitamins and any meds. I usually am up at 4:30am and for a lot of bloods I used to get there before it openned at 7am.

 

[Swifto]

My lipids (hdl, ldl etc) are a little out of whack post prep and I’m gonna try and fix them using none medical stuff so

High dose citrus bergamot (1.5-2g)
Red yeast extract 600mg
Grapeseed extract 1g
Coq 10 600mg
3G omega 3 with 600mg EPA & 300mg DHA per 1g
Cardio 5x 25 mins and 8-10k steps
Super clean diet


If all that fails I’ve got some pravastatin 10mg that I’m very reluctant to use

Herbal route, dietary changes and more activity/cardio is definitely the first option(s).

What about Reta?