Many bros believe that letro positively annihilates estrogen, reducing E2 by as much as 90%. I certainly accepted that idea.
But I just saw two studies in healthy men of various ages which would contradict this notion. The estrogen reductions were much more modest: 46-62%. And at 2.5mg/day. (And w/o a half gram of test!)
Here is one study:
Comparative Assessment in Young and Elderly Men of the Gonadotropin Response to Aromatase Inhibition -- T’Sjoen et al. 90 (10): 5717 -- Journal of Clinical Endocrinology & Metabolism
and I saw another that was similar. I think it is important that we are talking about results in men, not women.
I guess I'm wondering whether peoples' labs are really showing E2s of <15 on letro, or whether we need to change our idea that we can easily drive E2 to near zero on letro.
So, that begs the question: if studies are right and letro lowers E2 only 50%, why are so many people having libido issues? Is it definitely via Letro's estrogen reduction or is something else at work? ... Confusing
But I just saw two studies in healthy men of various ages which would contradict this notion. The estrogen reductions were much more modest: 46-62%. And at 2.5mg/day. (And w/o a half gram of test!)
Here is one study:
Comparative Assessment in Young and Elderly Men of the Gonadotropin Response to Aromatase Inhibition -- T’Sjoen et al. 90 (10): 5717 -- Journal of Clinical Endocrinology & Metabolism
and I saw another that was similar. I think it is important that we are talking about results in men, not women.
I guess I'm wondering whether peoples' labs are really showing E2s of <15 on letro, or whether we need to change our idea that we can easily drive E2 to near zero on letro.
So, that begs the question: if studies are right and letro lowers E2 only 50%, why are so many people having libido issues? Is it definitely via Letro's estrogen reduction or is something else at work? ... Confusing