Over 45 here. Been training since age 17 mostly non-stop
Juiced heavily 1995-2012, competed for a while and realized my limitations.
Still wanted to maintain my size, 240-245 at 5 eight, but had a real eye-opening physical 2 years ago. Blood profiles including hemoglobin all messed up. A bout with pancreatitis, due to too much Motrin after tearing a rotator cuff.
All of this combined with having a (now) 7-year old son, wanting more children and owning my own business. Made me finally realize that being Huge and bodybuilding is basically so irrelevant in the big scheme of things.
Never thought I voids ever say it. But for the past 2-3 years all I've done is a little test, no more than 200 mg/week. Weight is still 240 ish, not as hard but far more healthy. Physicals are fine now.
(Worst part is my first 8-9 years of competing and juicing were pre-internet and pre- doctor HRT and gear was so impossible to find. Nowadays it's infinitely easier and would have made a huge diff in my could-have-been career-- I never even tried GH until 5 years ago)
Overall not many regrets.