Liraglutide daily - for PM cravings

[whacked]

My PM food issues are so bad they have to be legendary. I can kill 10,000 calories w/o trying. Lol. J/k … sort of

I do great from the time I wake up at 6am…(I work out at 8am)…until 5pm hits and it’s just plain game over!

Nothing seems to help me put the dang fork down. I’m a mess at night. Lol.

Is anyone using this stuff at maybe 10-12pm so it kicks in by 3-5pm or so?

So … for PM control only?

I have tried Reta and Tirz in various doses and I feel “off / weird” and get horrible constipation. Just don’t care for either.

Thanks in advance!

 

[abt10]

This is professional muscle.. GLP1s are for guys who cant stick to a diet.

NOW GET TO SUFFERING PUNK!

 

[whacked]

Lol. I know I know

 

[Thahn]

This is professional muscle.. GLP1s are for guys who cant stick to a diet.

NOW GET TO SUFFERING PUNK!

Arnt you commenting in the reta thread saying you have 60 bottles....

 

[whacked]

Edit

 

[Jefe]

 

[romo]

Arnt you commenting in the reta thread saying you have 60 bottles....

yes he did lol

 

[romo]

My PM food issues are so bad they have to be legendary. I can kill 10,000 calories w/o trying. Lol. J/k … sort of

I do great from the time I wake up at 6am…(I work out at 8am)…until 5pm hits and it’s just plain game over!

Nothing seems to help me put the dang fork down. I’m a mess at night. Lol.

Is anyone using this stuff at maybe 10-12pm so it kicks in by 3-5pm or so?

So … for PM control only?

I have tried Reta and Tirz in various doses and I feel “off / weird” and get horrible constipation. Just don’t care for either.

Thanks in advance!

off / weird , good way of putting it. It did that to me and i couldn't really explain it.

 

[romo]

Great movie lol

 

[Jefe]

Maybe too much calorie restriction during the day? Easy to do that.

Eat some calorie neutral veggies at night. Raw cucumber, peppers, celery.

And stop whining!

 

[abt10]

yes he did lol

Nike..

 

[abt10]

Arnt you commenting in the reta thread saying you have 60 bottles....

Nike

 

[whacked]

Maybe too much calorie restriction during the day?

No. I still managed to eat decently on all of them. Lol. My appetite is nuts.

 

[bbxtreme]

What were your dosages and how often? Honestly if those two weren’t tolerable then Liraglutide won’t be much different as it’s likely just the GLP that you don’t feel well on.

With a GLP your best bet would be to slowly titrate up and give your body time to adjust. Reta seems to be better at appetite, but Tirz tolerated a bit more.

You could go a bit old school and just do a shot of melanotan 2 at 5pm. Stuff has been killing appetites way before GLP’s.

 

[sandiego_2008]

What were your dosages and how often? Honestly if those two weren’t tolerable then Liraglutide won’t be much different as it’s likely just the GLP that you don’t feel well on.

With a GLP your best bet would be to slowly titrate up and give your body time to adjust. Reta seems to be better at appetite, but Tirz tolerated a bit more.

You could go a bit old school and just do a shot of melanotan 2 at 5pm. Stuff has been killing appetites way before GLP’s.

MT2 for night cravings is very effective, that 5 minute nausea wave at 11pm will make anyone forget about eating. Nicotine gum also will crush cravings.

 

[OldManLogan]

Maybe try Cagrilintide with a GLP-1 if appetite is the main issue? See below

For the record I have NOT tried it. Tirz suppresses my appetite enough

Cagrilintide (aka Cagri) is a long-acting amylin analog developed for appetite suppression and weight loss, especially in combination with GLP-1 drugs like semaglutide or tirzepatide. Here’s the quick and dirty breakdown of how it works and why it’s gaining traction in the fat-loss pharmaco-toolbox:

⸻

What is Cagrilintide?
• It mimics amylin, a hormone co-secreted with insulin by pancreatic beta cells.
• Amylin plays a key role in satiety, gastric emptying, and glucagon suppression.
• Think of it as the “I’m full, stop eating” signal that GLP-1 doesn’t fully cover.

⸻

Mechanisms of Appetite Suppression

Cagrilintide acts through central and peripheral pathways:
1. Slows gastric emptying – You feel full longer.
2. Enhances satiety signaling – Works on the area postrema and hypothalamus.
3. Suppresses glucagon – Helps stabilize blood glucose and prevent hunger swings.
4. Amplifies GLP-1 action – Synergistic when paired with GLP-1 agonists like semaglutide or tirzepatide.

⸻

Why It’s a Big Deal
• Superior appetite control compared to GLP-1 alone
• Reduces food cravings, especially for hyperpalatable foods
• Delayed gastric emptying is more pronounced than GLP-1s
• In clinical trials (e.g., AMG 133 and SURMOUNT pipeline), it showed greater weight loss when combined with semaglutide

⸻

Data Highlights
• Cagrilintide + semaglutide = additive or even synergistic fat loss
• Weight loss in some studies: 15–20%+ total body weight over ~1 year
• May suppress food intake for longer periods than sema alone

⸻

Protocol (Experimental/Off-label Insight)

Note: Not FDA-approved yet as a standalone. Often sourced from research peptide suppliers.

• Dosing: ~0.3 mg up to 4.5 mg weekly (titrated slowly)
• Often co-dosed same day as GLP-1, or staggered based on side effects
• Injection: SubQ, similar to semaglutide

⸻

Side Effects (What to Expect)
• Nausea (especially if combined with GLP-1)
• Constipation or delayed bowel movements
• Possible hypoglycemia when combined with insulin or sulfonylureas
• Titration helps mitigate most GI issues

⸻

TL;DR

Cagrilintide is like semaglutide’s quiet but powerful wingman. It crushes hunger, slows digestion, and supercharges satiety—especially when stacked with GLP-1s. On its own? Solid. In a stack? Weaponized.

If you want a biochemical muzzle for your appetite, Cagri’s the muzzle. Just start low, go slow, and keep the barf bucket nearby the first week.

 

[whacked]

What were your dosages and how often? Honestly if those two weren’t tolerable then Liraglutide won’t be much different as it’s likely just the GLP that you don’t feel well on.

With a GLP your best bet would be to slowly titrate up and give your body time to adjust. Reta seems to be better at appetite, but Tirz tolerated a bit more.

You could go a bit old school and just do a shot of melanotan 2 at 5pm. Stuff has been killing appetites way before GLP’s.

Thanks BB
Shoot man. I can’t even remember. lol.
I started low on both after reading up on these and didn’t like them at all.
Just not a good fit for me. Felt bizarre.

I like the M2 angle lol

 

[whacked]

Maybe try Cagrilintide with a GLP-1 if appetite is the main issue? See below

For the record I have NOT tried it. Tirz suppresses my appetite enough

Cagrilintide (aka Cagri) is a long-acting amylin analog developed for appetite suppression and weight loss, especially in combination with GLP-1 drugs like semaglutide or tirzepatide. Here’s the quick and dirty breakdown of how it works and why it’s gaining traction in the fat-loss pharmaco-toolbox:

⸻

What is Cagrilintide?
• It mimics amylin, a hormone co-secreted with insulin by pancreatic beta cells.
• Amylin plays a key role in satiety, gastric emptying, and glucagon suppression.
• Think of it as the “I’m full, stop eating” signal that GLP-1 doesn’t fully cover.

⸻

Mechanisms of Appetite Suppression

Cagrilintide acts through central and peripheral pathways:
1. Slows gastric emptying – You feel full longer.
2. Enhances satiety signaling – Works on the area postrema and hypothalamus.
3. Suppresses glucagon – Helps stabilize blood glucose and prevent hunger swings.
4. Amplifies GLP-1 action – Synergistic when paired with GLP-1 agonists like semaglutide or tirzepatide.

⸻

Why It’s a Big Deal
• Superior appetite control compared to GLP-1 alone
• Reduces food cravings, especially for hyperpalatable foods
• Delayed gastric emptying is more pronounced than GLP-1s
• In clinical trials (e.g., AMG 133 and SURMOUNT pipeline), it showed greater weight loss when combined with semaglutide

⸻

Data Highlights
• Cagrilintide + semaglutide = additive or even synergistic fat loss
• Weight loss in some studies: 15–20%+ total body weight over ~1 year
• May suppress food intake for longer periods than sema alone

⸻

Protocol (Experimental/Off-label Insight)

Note: Not FDA-approved yet as a standalone. Often sourced from research peptide suppliers.

• Dosing: ~0.3 mg up to 4.5 mg weekly (titrated slowly)
• Often co-dosed same day as GLP-1, or staggered based on side effects
• Injection: SubQ, similar to semaglutide

⸻

Side Effects (What to Expect)
• Nausea (especially if combined with GLP-1)
• Constipation or delayed bowel movements
• Possible hypoglycemia when combined with insulin or sulfonylureas
• Titration helps mitigate most GI issues

⸻

TL;DR

Cagrilintide is like semaglutide’s quiet but powerful wingman. It crushes hunger, slows digestion, and supercharges satiety—especially when stacked with GLP-1s. On its own? Solid. In a stack? Weaponized.

If you want a biochemical muzzle for your appetite, Cagri’s the muzzle. Just start low, go slow, and keep the barf bucket nearby the first week.

Thank you.

I’m going to take a break from these for a bit and try to keep da fork outta da mouth again.

 

[3BILLS]

Is it all coming from clean food ?

 

[whacked]

Yes. I eat super clean; not because I am amazingly disciplined but because I feel like total garbage at my age when I don’t. lol. Just can’t get away with jack anymore. Lol.

Thanks