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Losartan lowers myostatin post workout in older subjects

nothuman

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Blood Pressure Drug Losartan Lowers Post-Workout Myostatin Level in Older Subjects
A recent RCT investigated the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle.

The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-[beta] and upregulation of IGF-1 signalling... well, not exactly what happened.

28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise. Participants performed one bout of heavy unilateral resistance exercise. Six muscle biopsies were obtained from the vastus lateralis muscles of each subject: two before exercise, and four after exercise (4.5 hours and 1, 4 and 7 days). Blood pressure and blood samples were collected at the same time points. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells associated with type I and type II fibres. Gene expression levels of Notch, connective tissue and myogenic signalling pathways were determined by real time RT-PCR.

Changes over time were detected for circulating creatine kinase, the number of satellite cells per type I fibre and most of the gene targets, with no specific effect of losartan on these. However, when compared with placebo, Losartan intake resulted in a greater suppression of myostatin mRNA.

suppversity.com | Heisterberg, Mette Flindt; Andersen, Jesper L.; Schjerling, Peter; Bülow, Jacob; Lauersen, Jeppe Bo; Roeber, Heidi L.; Kjaer, Michael; Mackey, Abigail L. "Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise." Medicine & Science in Sports & Exercise: Post Acceptance: October 16, 2017 - doi: 10.1249/MSS.0000000000001438
 
I'd like to think Telmisartan does the same, hopefully in younger subjects too.
 
been on 100mg of losartan for 13 years, I was on the drug before losartan(generic) came out, I believe it was alvapro or something like that
 
"In rare cases, losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. [Quote, https://www.drugs.com/losartan.html ]"..what? breakdown of muscle tissue leading to renal failure??? breakdown of muscle tissue does increas creatinine temporary nut havent heard that can cause renal disease...
 

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