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Blood Pressure Drug Losartan Lowers Post-Workout Myostatin Level in Older Subjects
A recent RCT investigated the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle.
The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-[beta] and upregulation of IGF-1 signalling... well, not exactly what happened.
28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise. Participants performed one bout of heavy unilateral resistance exercise. Six muscle biopsies were obtained from the vastus lateralis muscles of each subject: two before exercise, and four after exercise (4.5 hours and 1, 4 and 7 days). Blood pressure and blood samples were collected at the same time points. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells associated with type I and type II fibres. Gene expression levels of Notch, connective tissue and myogenic signalling pathways were determined by real time RT-PCR.
Changes over time were detected for circulating creatine kinase, the number of satellite cells per type I fibre and most of the gene targets, with no specific effect of losartan on these. However, when compared with placebo, Losartan intake resulted in a greater suppression of myostatin mRNA.
suppversity.com | Heisterberg, Mette Flindt; Andersen, Jesper L.; Schjerling, Peter; Bülow, Jacob; Lauersen, Jeppe Bo; Roeber, Heidi L.; Kjaer, Michael; Mackey, Abigail L. "Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise." Medicine & Science in Sports & Exercise: Post Acceptance: October 16, 2017 - doi: 10.1249/MSS.0000000000001438
A recent RCT investigated the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle.
The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-[beta] and upregulation of IGF-1 signalling... well, not exactly what happened.
28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise. Participants performed one bout of heavy unilateral resistance exercise. Six muscle biopsies were obtained from the vastus lateralis muscles of each subject: two before exercise, and four after exercise (4.5 hours and 1, 4 and 7 days). Blood pressure and blood samples were collected at the same time points. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells associated with type I and type II fibres. Gene expression levels of Notch, connective tissue and myogenic signalling pathways were determined by real time RT-PCR.
Changes over time were detected for circulating creatine kinase, the number of satellite cells per type I fibre and most of the gene targets, with no specific effect of losartan on these. However, when compared with placebo, Losartan intake resulted in a greater suppression of myostatin mRNA.
suppversity.com | Heisterberg, Mette Flindt; Andersen, Jesper L.; Schjerling, Peter; Bülow, Jacob; Lauersen, Jeppe Bo; Roeber, Heidi L.; Kjaer, Michael; Mackey, Abigail L. "Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise." Medicine & Science in Sports & Exercise: Post Acceptance: October 16, 2017 - doi: 10.1249/MSS.0000000000001438