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Came across this article that sounds quite interesting:
Could the Therapy For Atherosclerosis and Heart Attack Come With a Tan?
Heart Disease is the leading cause of death in America. The sun-tanning peptide Melanotan II may be the next big drug therapy breakthrough to fight Atherosclerosis, Heart Attack and Chronic Inflammation
Activation of the Melanocortin system appears to help reduce inflammation in arteries and blood vessels that influences the buildup of plaques and stiffness one study showed. When mice prone to developing Atherosclerosis were give Melanotan II for 4 weeks the therapy showed a marked reduction in the buildup of new plaques and reduced systemic markers of inflammation as compared to controls which were given the vehicle only. While this study did not show a reduction in the size of existing plaque lesions it did also show enhanced endothelium-dependant relaxation and improved vascular sensitivity to nitric oxide's effects.
Another study looked at the effects of Melanotan II on post-ischemic recovery of the heart after a myocardial infarction and showed some amazing benefits. Once again by mediating the inflammatory response through enhanced macrophage activity, the heart was protected against collateral damage which is normally seen in the reperfusion period after a heart attack. And these benefits were shown to last well beyond the 24 hour post-reperfusion period where much of the delayed heart damage is usually seen.
One caveat is that Melanotan II ha also been shown to elevate blood pressure in studies that look at its effects on hemodynamics. This is a worrisome byproduct of using Melanotan II in individuals who have impaired heart function. I suspect that just the way they isolated the portion of the Melanotan II peptide to render the portion that influences increased libido in the development of PT-141 (bremelanotide), they will attempt to identify the portion of the Melanotan II peptide responsible for these antiinflammatory effects and leave out the blood-pressure-elevation part of the peptide.
https://superhumanradio.net/blog/co..._Xu2d9ElfXaJCSeq-7eU4momroobf2K4A_TPnsHIbeTOA
Could the Therapy For Atherosclerosis and Heart Attack Come With a Tan?
Heart Disease is the leading cause of death in America. The sun-tanning peptide Melanotan II may be the next big drug therapy breakthrough to fight Atherosclerosis, Heart Attack and Chronic Inflammation
Activation of the Melanocortin system appears to help reduce inflammation in arteries and blood vessels that influences the buildup of plaques and stiffness one study showed. When mice prone to developing Atherosclerosis were give Melanotan II for 4 weeks the therapy showed a marked reduction in the buildup of new plaques and reduced systemic markers of inflammation as compared to controls which were given the vehicle only. While this study did not show a reduction in the size of existing plaque lesions it did also show enhanced endothelium-dependant relaxation and improved vascular sensitivity to nitric oxide's effects.
Another study looked at the effects of Melanotan II on post-ischemic recovery of the heart after a myocardial infarction and showed some amazing benefits. Once again by mediating the inflammatory response through enhanced macrophage activity, the heart was protected against collateral damage which is normally seen in the reperfusion period after a heart attack. And these benefits were shown to last well beyond the 24 hour post-reperfusion period where much of the delayed heart damage is usually seen.
One caveat is that Melanotan II ha also been shown to elevate blood pressure in studies that look at its effects on hemodynamics. This is a worrisome byproduct of using Melanotan II in individuals who have impaired heart function. I suspect that just the way they isolated the portion of the Melanotan II peptide to render the portion that influences increased libido in the development of PT-141 (bremelanotide), they will attempt to identify the portion of the Melanotan II peptide responsible for these antiinflammatory effects and leave out the blood-pressure-elevation part of the peptide.
https://superhumanradio.net/blog/co..._Xu2d9ElfXaJCSeq-7eU4momroobf2K4A_TPnsHIbeTOA
