Works really well. I have type 4 skin so I didn't bother with the loading period, just went with 500mcg about twice a week spaced out a few days at first. I found that even 500mcg really seemed to upset my stomach, and not just for a half hour, but for hours afterwards. Using 250mcg seemed to alleviate this and I still seemed to get the same results only using it twice a week. YMMV though depending on your skin type and how sensitive you are to it. I suppose I might just be very sensitive to the effects since 500mcg made my stomach hurt for so long.
I added 2ML bac water to make small dosages easier to fill =)