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Melatonin - Potent AI?

TheShadow

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Oct 20, 2016
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Check out this research, where melatonin, reservatrol and letrozole were added into breast adipose tissue in vitro.

As we know, aromatisation of testosterone to estrogen can occur at the aromatase enzyme in fat cells.

Both melatonin and reservatrol were found to act as aromatase inhibitors in this co-culture model, however, melatonin was 1000x more potent than reservatrol.

The most surprising finding here was that melatonin was equally as potent as letrozole!

Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts - ScienceDirect



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suppdude

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Curious dose being used


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nothuman

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Not for me even at 10mg before bed. E2 was still high on 20mg cyp daily
 

chinaboy

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Using melatonin nearly all my life I have never found it to have any AI properties that I noticed.
 

buck

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Using melatonin nearly all my life I have never found it to have any AI properties that I noticed.

If you used it all your life how can you tell if it didn't work? Your E2 levels may have been even higher without it.
 

G-FLUX

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Remember guys, nearly every supplement out there has dozens of potential benefits...but that doesnt mean its going to correlate to real world results given our own situational needs.
 

lntense

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Doesn't melatonin lower FSH?
 

buck

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As melatonin production in men starts to decrease around age 30 the same time that testosterone production starts to decrease. I do not think in real world terms that it would have that affect.
 

johnjuanb1

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Check out this research, where melatonin, reservatrol and letrozole were added into breast adipose tissue in vitro.

As we know, aromatisation of testosterone to estrogen can occur at the aromatase enzyme in fat cells.

Both melatonin and reservatrol were found to act as aromatase inhibitors in this co-culture model, however, melatonin was 1000x more potent than reservatrol.

The most surprising finding here was that melatonin was equally as potent as letrozole!

Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts - ScienceDirect



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Wow!!! Cool post. Thank you
Another good thing about my prebed 3mg of melatonin
 

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