I'm a little concerned that combining them isn't as good as aspirin/white willow bark alone. The study is on crickets but still, makes me wonder if adding things up is less effective sometimes than doing things on their own.
Doing 2 grams a day morning/evening meals split SR version. However as a test, I am going to try 1700mg of the regular version in the same dosing pattern and see if I notice a difference or get any sides.
Promotes life span but not so much protection from heart attacks, which is ironically why people take it. I choose White Willow Bark over aspirin since it's the same benefits without the blood thinning and possible gastro issue.
I've tried metformin last year when i was still natty.
I started with 500 mg once a day at dinner, then gradually increased to 2000 mg/day on my high carbs day only, usually splitted into two doses of 1000 mg.
Had no major sides, probably a bit of stomach discomfort at the beginning.
I've found that it kept my muscles fuller on very low carb days and on carbs refeed it prevented spillover very well, shuttling all carbs inside muscles. Much less fat gain on prolonged high carbs diet too.
The day after a carbs refeed plus 2000 mg of metformin the pumps in the gym were insane and even painful, muscles were full, hard and vascular.
No lethargy, rather i had an energies and endurance increase.
I stopped taking metformin since i've read that it can mess up with androgen receptors signalling and it leads to an SHBG increase, reducing free test levels.