Metformin Questions

[Midnight Temptation]

My primary just prescribed 500mg/day of Metformin. My Dr prescribed it for me because she said my A1C was elevated(but my glucose was low)

Can anyone explain their use and results with Metformin? Specifically did it help with weight loss? Insulin resistance? And carbohydrate partitioning?

 

[FrancisK]

Metformin has been one of the most thoroughly discussed topics on this forum the past couple years and there has been some invaluable pieces of information which came from heated debates by some of the best minds on this board in regards to aspects of it you may not even considered, important things certainly not addressed by general knowledge and information. Any reply to this thread would pale in comparison to the importance of the information found in those threads.

Do a search, hunker down and start reading, you’re going to be at it a while

 

[Bobik]

Metformin has been one of the most thoroughly discussed topics on this forum the past couple years and there has been some invaluable pieces of information which came from heated debates by some of the best minds on this board in regards to aspects of it you may not even considered, important things certainly not addressed by general knowledge and information. Any reply to this thread would pale in comparison to the importance of the information found in those threads.

Do a search, hunker down and start reading, you’re going to be at it a while

Yes. I started taking Metformin based on the information in this forum.... a lot of information here.

 

[whacked]

2 Metformin newbie questions.

Any potential issues taking Metformin and Telmisartan together?

Can Metformin make you go hypo if not enough carbs are ingested? I understand this is not Slin, but still concerned bc I’m a lower carb guy (100/day).

Thanks

 

[Bumpygooch]

I take them both, chances of going hypo with metformin are extremely low. I’m on keto, no issues.

 

[DarrenG29]

It will lower your blood sugar levels as I use it being type2 and blood sugar can lower simple diet tweak fixes it

 

[prodaf]

2 Metformin newbie questions.

Any potential issues taking Metformin and Telmisartan together?

Can Metformin make you go hypo if not enough carbs are ingested? I understand this is not Slin, but still concerned bc I’m a lower carb guy (100/day).

Thanks

No hypo with metformin

 

[aphextwin]

2 Metformin newbie questions.

Any potential issues taking Metformin and Telmisartan together?

Can Metformin make you go hypo if not enough carbs are ingested? I understand this is not Slin, but still concerned bc I’m a lower carb guy (100/day).

Thanks

No and no

 

[Muay Thai]

Its good stuff and has both positive and negative press. Personally I have always got shredded with it. loose stool is real on it . If you treat it like insulin and time your carbs pre intra post correctly you can really amplify the results. It improved my general sense of well being after about a month as well maybe I was just pleased with the recomp effect lol

 

[opietaylor]

how long until you can see a number drop on your fasted blood glucose when incorporating metformin?

 

[aphextwin]

how long until you can see a number drop on your fasted blood glucose when incorporating metformin?

That’s a good question. I have been wondering about that as well.

 

[aphextwin]

I think Metformin should used by pretty much anyone who is looking into it for longevity. If someone has side effects it’s probably not for you. I remember experiencing diarrhea at first but it quickly disappeared. I’ve been taking it for years....For me, it’s like an aspirin.

 

[TheOtherOne55]

TONS of threads on here.

Go to google and type in "metformin professionamuscle" and see what comes up.

 

[opietaylor]

well I can say berberine does absolutely zero for me

 

[opietaylor]

TONS of threads on here.

Go to google and type in "metformin professionamuscle" and see what comes up.

I did and found no one stating my FBG was x and now it is y and this is how long it took and the specific amount I used.

 

[DarrenG29]

That’s a good question. I have been wondering about that as well.

1 week and upwards to 3 months to see stable results.

 

[Stewie]

how long until you can see a number drop on your fasted blood glucose when incorporating metformin?

Take a look at the graphs and charts within. You'll see a reduction in glucose levels within a few hours after administration. There's a dose relationship given two different forms of metformin.

To summarize, after a few hours there's a reduction, although it'll take a steady state of repetitive dosing to keep that stable. Hit and miss dosing will not net the same results.

Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials - Diabetologia

Aims/hypothesis Delayed-release metformin (Metformin DR) was developed to maximise gut-based mechanisms of metformin action by targeting the drug to the ileum. Metformin DR was evaluated in two studies. Study 1 compared the bioavailability and effects on circulating glucose and gut hormones...

link.springer.com

 

[aphextwin]

One thing I have really noticed is switching to ER version my appetite for sweets has become significantly less. I’m starting to wonder if that’s why my overall appetite has diminished. If it has, I’ll have to switch back to the reg version

 

[Matsuo Munefusa]

Take a look at the graphs and charts within. You'll see a reduction in glucose levels within a few hours after administration. There's a dose relationship given two different forms of metformin.

To summarize, after a few hours there's a reduction, although it'll take a steady state of repetitive dosing to keep that stable. Hit and miss dosing will not net the same results.

Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials - Diabetologia

Aims/hypothesis Delayed-release metformin (Metformin DR) was developed to maximise gut-based mechanisms of metformin action by targeting the drug to the ileum. Metformin DR was evaluated in two studies. Study 1 compared the bioavailability and effects on circulating glucose and gut hormones...

link.springer.com

Can you not achieve a steady state with once per day instant release 500mg at night?

 

[Stewie]

Can you not achieve a steady state with once per day instant release 500mg at night?

Sure you can.

The "hit and miss" remark is referring to taking it only a few times per week or here and there when gorging down huge carb feeds like some individuals do.