My A1C was usually between 5-5.4 when taking Metformin and/or Berberine
I have been off Metformin and/or Berberine for four months now, and I just got a 4.8 A1C, an improvement. It's like I'm finally getting the health/glucose benefits of weight lifting and cardio that Metformin was preventing me from having.
Unless metformin attenuates exercise through some other mechanism than AMPK then berberine would also attenuate exercise it appears.
Rex.