what are your experiences with this just got some been on 3 days first day was horrible but getting mega fullnes on 1000mg a day
could i take it without a carb meal say just 250mg to improve insulin snsitivity ?
what are your experiences with this just got some been on 3 days first day was horrible but getting mega fullnes on 1000mg a day
could i take it without a carb meal say just 250mg to improve insulin snsitivity ?
I've experimented with it. Had no negative sides and got a nice sensation of fullness, as you said. Wasn't tired even after a slug of pasta.
I'm a little afraid of taking it all the time since I'm taking peptides + gh, and I don't want to interfere with igf-1 / mTor pathways. DAT has some posts on metformin ... claims that metformin may reduce peptides' effectiveness.
But I liked metformin as far as my personal experience went.
being that its an alternative to using insulin, shouldn't it be synergistic with gh and peptides???
People should understand that metformin's primary mode of action is activation of AMPK. AMPK is like a very sensitive cellular fuel gauge. The higher the level of AMPK, the stronger the signal of "empty." The result of increasing AMPK is that energy producing pathways are promoted and energy consuming pathways are inhibited.
The good news is along the lines of energy producing pathways. AMPK increases insulin sensitivity, enhances glucose uptake, increases fatty acid oxidation, and stimulates insulin-independent glucose uptake (i.e. glucose uptake that doesn't require insulin). The downside is that energy consuming pathways are also inhibited. This includes protein synthesis. AMPK directly inhibts mTOR, which is one of the most downstream signaling proteins regulating protein synthesis.
Basically, when you take metformin, not only are you improving glucose uptake, you're mimicking the cellular signal for "empty," which inhibits things that consume energy, including protein synthesis.
How do you guys know it lowers igf, etc? Where have you seen actual evidence of this? Is it just because other people on the boards say it? Do you think you could actually tell that if was lowering igf?