MGF any good ?

[DatBtrue]

...Seems like these peptides are mostly a waste for the most part...But, its so hard to tell with them, if they are working or not...

Peg-MGF is what people hoped IGF-1 LR3 would be. It is a much more effective IGF-1. From what I can tell it works well at the right dose ...but it works like IGF-1 (meaning differentiation not proliferation).

Peg or unpeg MGF will not ever behave like native MGF. If you want to understand why then read my following post: http://www.professionalmuscle.com/forums/showpost.php?p=487161&postcount=349

I realize most people don't want to understand and so I don't usually call attention to it.

I also don't really care and I don't really like to abuse people's illusions.

 

[chris250]

So Peg MGF is better than MGF ??? Is that correct ??? Because of the longer half life of PEG MGF ???

 

[chris250]

Im sooooo confused about all this peptide stuff ...LOL !!!

 

[Big Bapper]

So Peg MGF is better than MGF ??? Is that correct ??? Because of the longer half life of PEG MGF ???

They are both the same thing, Peg MGF is just longer acting.

 

[DatBtrue]

So Peg MGF is better than MGF ??? Is that correct ??? Because of the longer half life of PEG MGF ???

PEG is often used as shorthand for PEGylation (the process of attaching PEG to a compound)

PEG really though is polyethylene glycol.

In order to protect a drug or compound from either enzyme degradation or from the body seeing the drug/compound as something it needs to destroy certain things can be done.

One of those things is attaching PEG to the drug or compound.

MGF (is a variant of IGF-1). If you inject it into plasma it will degrade pretty quickly. You can still buy MGF but it just breaks down too quickly.

If you take PEG and attach it to the structure of MGF you "shelter" certain portions of the structure that are easily degradable.

For instance the amino acid Arginine & Lysine are subject to degradation unless protected from enzymes that want to break it apart. PEG either blocks them from getting to those weak points or from recognizing them in the first place.

So PEG-MGF has a longer life when injected into plasma.

Now you can attach PEG in several places on a peptide. I believe there are two versions of PEG-MGF which vary by where PEG is attached. One anecdotally is working better then the other.

Why?

Because when you attach PEG to a peptide to shelter it you might also change its ability to bind to a receptor. The ability or strength of binding is often called "affinity".

So one of the PEG-MGFs probably has a stronger binding affinity for the IGF-1 receptor then the other.

In fact that one PEG-MGF probably has a stronger binding affinity for the IGF-1 receptor then IGF-1 LR3. Which makes PEG-MGF a better IGF-1 then IGF-1 LR3.

So we have two things to consider... longevity of the peptide and binding affinity.

Regular MGF has no alteration and may have a stronger binding to the IGF-1 receptor then PEG-MGF BUT its short life and susceptibility to quick breakdown mean far less of it will actually end up bound to an IGF-1 receptor.

PEG-MGF has a longer life and although it may not bind as strongly or quickly eventually more of it will bind to an IGF-1 receptor.

 

[BigBastard]

Bump for more IRL feedback on MGF.

 

[BigBastard]

Also, how long will mixed MGF (with bac water) stay fresh?

 

[td1111]

So all in all, peptides never quite do what you really want, compared to using HGH and Slin to create your own endogenous, IGF, etc.