Mitochondria testing

[hogan87]

All this hype about mitochondria peptides mots-c, SLU PP, ss31.... What says you even need them? Anyone consider testing their mitochondria? It`s $699, at home, mail in test. As a provider I can get it for like $400 I think (not trying to sell anyone) and I`m still not sure I wanna drop the cash. I fell those peptides have done nothing for me. I don`t believe the results would recommend any peptides but here is a sample test report if anyone is interested :https://mescreen.com/pages/example-report

I know more test and a little tren will give me added benefit, no prior testing needed. LOL.

 

[specter]

All this hype about mitochondria peptides mots-c, SLU PP, ss31.... What says you even need them? Anyone consider testing their mitochondria? It`s $699, at home, mail in test. As a provider I can get it for like $400 I think (not trying to sell anyone) and I`m still not sure I wanna drop the cash. I fell those peptides have done nothing for me. I don`t believe the results would recommend any peptides but here is a sample test report if anyone is interested :https://mescreen.com/pages/example-report

I know more test and a little tren will give me added benefit, no prior testing needed. LOL.

I can make you a similar "document" for $299 ? and make up all kinds of info you have 0 chance to verify...

 

[hogan87]

I can make you a similar "document" for $299 ? and make up all kinds of info you have 0 chance to verify...

I`m not selling the test, zero affiliation. This is the only company I can find doing any type of mitochondria testing. My larger point is, everyone taking these peptides without even knowing if its needed. It would be nice to verify, ok yes, this part of my body needs help, before spending $$ and daily shots for months.

 

[Massive G]

All this hype about mitochondria peptides mots-c, SLU PP, ss31.... What says you even need them? Anyone consider testing their mitochondria? It`s $699, at home, mail in test. As a provider I can get it for like $400 I think (not trying to sell anyone) and I`m still not sure I wanna drop the cash. I fell those peptides have done nothing for me. I don`t believe the results would recommend any peptides but here is a sample test report if anyone is interested :https://mescreen.com/pages/example-report

I know more test and a little tren will give me added benefit, no prior testing needed. LOL.

Would you take steroids if you got no benefit?
I think its the new hype out there and there's a huge market for it. I have felt every peptide I have taken. Also have seen benefits in blood work and overall well-being. I am older 50 + so I am a lab rat like the rest of us. Peptides aren't for everyone and you won't see huge results off them overnight.

 

[Stewie]

I`m not selling the test, zero affiliation. This is the only company I can find doing any type of mitochondria testing. My larger point is, everyone taking these peptides without even knowing if its needed. It would be nice to verify, ok yes, this part of my body needs help, before spending $$ and daily shots for months.

Chris Masterjohn, PhD also sells mitochondria analysis kits. At roughly the same price.

Mitome | At-Home Mitochondria Function Test — Chris Masterjohn PhD

Mitome offers the first at-home mitochondrial function test, providing personalized insights to help optimize energy, slow aging, and improve overall cellular health.

www.chrismasterjohn-phd.com

Only if there was DTC whole cell assays– that would be more worthy.

I do agree with your overall premise of randomly taking a mitokine– signaling peptide without assessing mitochondrial function.

 

[buck]

People taking a lot of something really isn't proof it works. I remember the HCG diet craze that swept the country and how hard it was to get HGC and the price skyrocketed. And all the people that swore it was pure magic.
My personal experience from most peps i have taken over the years left me vastly underwhelmed.
The more lab testing i have been doing in the last few years shows i am not as bad off as i would have thought.
A mitochondria test is something i may look into.
Considering what the price is to be on some of the peps long term a few hundred dollars for a test is just a decent investment in my self as i see it.

 

[hawkmoon]

While popular at the moment, this is an area where I’d use a very light touch. Call me a pussy, but mitochondrial function is not something I want to mess with.

Mitochondrial function can’t really be 'tested' either. You can look at mtDNA for mutations that may perpetuate certain outcomes, and you might extrapolate some possibilities from that.
However, when diagnosing a true mitochondrial disorder, I believe a muscle biopsy is required.

 

[specter]

I`m not selling the test, zero affiliation. This is the only company I can find doing any type of mitochondria testing. My larger point is, everyone taking these peptides without even knowing if its needed. It would be nice to verify, ok yes, this part of my body needs help, before spending $$ and daily shots for months.

Oh i got that man, i just find these test at home kits funny, personally i dont think we are so far along we can do these tests and give people any useful information. But i get your point and yeah shooting a ton of shit not knowing it works is kinda funny, but then again its been like that forever with bodybuilders, we just love new shiny drugs

 

[Stewie]

While popular at the moment, this is an area where I’d use a very light touch. Call me a pussy, but mitochondrial function is not something I want to mess with.

Mitochondrial function can’t really be 'tested' either. You can look at mtDNA for mutations that may perpetuate certain outcomes, and you might extrapolate some possibilities from that.
However, when diagnosing a true mitochondrial disorder, I believe a muscle biopsy is required.

You're 100% correct for confirming mutations of either mtDNA or nDNA. My previous commentaries– "Only if there was DTC whole cell assays– that would be more worthy." – that would be via peripheral tissue sampling (biopsy).

Core biopsies would be the final determination vs saliva or peripheral blood.

Peripheral blood does harbor mtDNA such as mononuclear cells (lymphocytes and monocytes). This has limitations in contrast to peripheral tissue (whole cell [biopsy]). There's several diagnostic laboratories that are clinically accredited using peripheral blood analyzing mtDNA for mutations/disorders.

 

[hawkmoon]

You're 100% correct for confirming mutations of either mtDNA or nDNA. My previous commentaries– "Only if there was DTC whole cell assays– that would be more worthy." – that would be via peripheral tissue sampling (biopsy).

Core biopsies would be the final determination vs saliva or peripheral blood.

Peripheral blood does harbor mtDNA such as mononuclear cells (lymphocytes and monocytes). This has limitations in contrast to peripheral tissue (whole cell [biopsy]). There's several diagnostic laboratories that are clinically accredited using peripheral blood analyzing mtDNA for mutations/disorders.

Regarding blood samples, I think at least one of these genpop testing companies uses what will be dried blood samples. I could be wrong, but I think the value in dried blood for these tests is quite low. I'd wager you know more about this than I.

 

[Stewie]

Regarding blood samples, I think at least one of these genpop testing companies uses what will be dried blood samples. I could be wrong, but I think the value in dried blood for these tests is quite low. I'd wager you know more about this than I.

Masterjohn uses buccal swab testing. It's not picking up mtDNA insertions, deletions or duplications– it's not looking for mutations. It's picking up different enzymatic respiratory chains efficiencies or lack thereof.

I'm not sure how the sampling is done that @hogan87 shared?

 

[Stewie]

From my understanding with these at-home mitochondrial test kits is that it'll provide a functional snapshot of your mitochondrial respiratory chain performance. There may be other cyclic reactions or enzymes they're analyzing?

I would only suspect (?) given the price, they'll outline you a personalized nutrigenomics style recommendation if in the event you have some lagging complexes.e.g.. intermediates, cofactors and substrates.

Then for ongoing optimization, you'd rinse and repeat the testing, which could become quite expensive given the $700 price per kit.

Could these mitochondria testing give you reasons to tease out potential pitfalls prior to dabbling with different mitochondria specific peptides. I suspect it could help indirectly.

 

[bbxtreme]

If someone wanted to fully explore I would use Mitome to test for mitochondria function. Then do at OAT test to understand metabolic needs for over stressed mitochondria.

Masterjohn is not a huge fan of SS31.

The more I dig into this field though the more I come back to wanting to save my money, take CoQ10 and ensure proper mineral and vitamin status.

A peptide can serve as a “boost” or bridge, but they’re not meant to be a long term fix. That’s where the above foundational items come into play which are easy to neglect. Most people don’t have a peptide deficiency.

 

[buck]

If someone wanted to fully explore I would use Mitome to test for mitochondria function. Then do at OAT test to understand metabolic needs for over stressed mitochondria.

Masterjohn is not a huge fan of SS31.

The more I dig into this field though the more I come back to wanting to save my money, take CoQ10 and ensure proper mineral and vitamin status.

A peptide can serve as a “boost” or bridge, but they’re not meant to be a long term fix. That’s where the above foundational items come into play which are easy to neglect. Most people don’t have a peptide deficiency.

A CoQ10 test is next on my list.
Found out i was over doing my magnesium when i had it tested.
And even with supplementing with a fair amount of omega 3's i was far from optimal.

 

[bbxtreme]

A CoQ10 test is next on my list.
Found out i was over doing my magnesium when i had it tested.
And even with supplementing with a fair amount of omega 3's i was far from optimal.

A bodybuilder who has food diversity covered will need less supplements than they think given how much they eat.

 

[buck]

A bodybuilder who has food diversity covered will need less supplements than they think given how much they eat.

I agree. As i am 66 i tend to figure assimilation or natural production ain't what it used to be when i was superman. Added to that my calorie consumption is less then decades ago too.
Lipase and amylase production is down so i am guessing that explains some things such as poor absorption of omega 3's.

 

[nothuman]

I don’t trust any mitochondria test yet until we have much better evidence. $700 for a test that probably won’t give us much actionable information doesn’t sound like a good deal to me. It is obvious that mitochondria is important, but there’s so much about it that we don’t understand.

 

[nothuman]

On the topic of CoQ10…

We know it is part of our mitochondria, but contrary to popular belief, the evidence that taking the supplement improves our mitochondria is very poor

Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults - GeroScience

Mitochondrial function is important to healthy aging, as it influences energy metabolism, oxidative stress, and physical performance. With age, mitochondrial function and biosynthesis of coenzyme Q10 (CoQ10) may change. CoQ10 serves as a key antioxidant and component of the electron transport...

link.springer.com

 

[Stewie]

I don’t trust any mitochondria test yet until we have much better evidence. $700 for a test that probably won’t give us much actionable information doesn’t sound like a good deal to me. It is obvious that mitochondria is important, but there’s so much about it that we don’t understand.

On the topic of CoQ10…

We know it is part of our mitochondria, but contrary to popular belief, the evidence that taking the supplement improves our mitochondria is very poor

Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults - GeroScience

Mitochondrial function is important to healthy aging, as it influences energy metabolism, oxidative stress, and physical performance. With age, mitochondrial function and biosynthesis of coenzyme Q10 (CoQ10) may change. CoQ10 serves as a key antioxidant and component of the electron transport...

link.springer.com

Are you suggesting all mitochondrial testing including clinically accredited institutions or specifically DTC?

Are you aware there's actually an autosomal recessive metabolic disorder, namely primary CoQ10 deficiency. Treatment – high doses of CoQ10.

I'm not dismissing healthy people supplementation—that often shows limited benefit, sure. Just like NAD+ precursors. Diseased state is a totally different talking point.

There's numerous mitochondrial disorders that are specifically dx' through different methodologies of mitochondrial testing, including all the aforementioned.

 

[professionaldyel]

last time I brought up mitochondria testing here I got told "that isnt how any of this works" because of sponsorship pedaling lol https://www.professionalmuscle.com/forums/index.php?threads/slu-pp-332.182654/post-3561667