So I started mk677 early November, 12.5mg each day. I slowly ramped up to 25 mg by end of November. The benefits have been huge I have lost 20lbs, my skin feels amazing. Sleep was a struggle for weeks on end terrible night time loss of feeling in the hands, right down to the elbow, had to hang each arm off the bed awhile to get back to sleep. I used generic hgh around 6ius this feeling was kicking the generics butt. So around a week ago I was not getting the numbness at night. My supply was running short so I lowered my dose back to 12.5. To my surprise I feel like I releasing more hgh and more frequent pulses. I can't even sleep in the morning the numbness is so bad my hands are swollen. Makes no sense, it was not my intention to lower the dose but due finances I had to. Why on earth would lowering my dose cause such a boost. My only conclusion is concentrated dose towards the end of the bottle. I'm pretty ocd so I always shake the bottle before each use. Please can anyone offer a possible reason why?