Mots C and blood glucose

[Simon90]

Anyone else notice when starting mots c they had a period of time with elevated blood sugar readings?

Higher fasted, higher peaks and higher post prandial readings. Not by a small amount either we are talking 1 to 2 full points fasted and peak reading and sometimes up to 3 higher post prandial (usually 2 hours after my meal before my next u am sitting between 4 and 5 max as a norm. Now it's been as high as 7 still.

I've personally not seen anyone else talk about this online, but after asking chat gpt and troponin app, it seems normal and can be expected to last for up to 3 to 4 weeks before improvement.

For anyone interested here's a copy and paste from troponin:


MOTS-C

MOTS-C works by improving mitochondrial function and insulin sensitivity, but there's often an initial adaptation period where your body is essentially "recalibrating" its metabolic processes. Think of it like this - you're upgrading your cellular machinery, but during the installation process, things might run a bit differently than usual.

A few things could be happening:

Mitochondrial adaptation phase: Your cells are becoming more efficient at glucose uptake and utilization, but this process takes time to fully optimize
Insulin sensitivity changes: As your sensitivity improves, your body might temporarily overproduce glucose in response to what it perceives as changing insulin dynamics

Metabolic flexibility shifts: MOTS-C enhances your ability to switch between fuel sources, and during this transition, glucose regulation can be temporarily affected

Timeline and What to Expect

In my experience with clients using MOTS-C, this initial period typically lasts 2-4 weeks. Most people see their blood sugar readings normalize and then improve beyond baseline after about a month of consistent use.

 

[luki7788]

but are you talking about mg/dl or mmol/l ? because it completely changes the context - in the first case 1-2 points is nothing, in the second there is a big difference

 

[MajinBoo]

Anyone else notice when starting mots c they had a period of time with elevated blood sugar readings?

Higher fasted, higher peaks and higher post prandial readings. Not by a small amount either we are talking 1 to 2 full points fasted and peak reading and sometimes up to 3 higher post prandial (usually 2 hours after my meal before my next u am sitting between 4 and 5 max as a norm. Now it's been as high as 7 still.

From that sentence I assume your are talking about mmol/L
A post prandial up to 7.5~7.8 is still considered "normal". Not ideal, but not necessarly a sign of insulin insulin resistance.

Will MOTS-C improve insulin sensitivity? From what I have seen, yes, it will. Now the dosage is personal and scenario dependent. I mostly used 1mg/day and noticed a slight improvement but know some people who noticed improvements at 2mg/day or higher.

Now I don't know your routine/diet/movement/etc and if there are easy fixes without having to use a peptide. I would start from there.

 

[Simon90]

but are you talking about mg/dl or mmol/l ? because it completely changes the context - in the first case 1-2 points is nothing, in the second there is a big difference

Yeah, mmol/L, so it is a big difference

 

[Simon90]

From that sentence I assume your are talking about mmol/L
A post prandial up to 7.5~7.8 is still considered "normal". Not ideal, but not necessarly a sign of insulin insulin resistance.

Will MOTS-C improve insulin sensitivity? From what I have seen, yes, it will. Now the dosage is personal and scenario dependent. I mostly used 1mg/day and noticed a slight improvement but know some people who noticed improvements at 2mg/day or higher.

Now I don't know your routine/diet/movement/etc and if there are easy fixes without having to use a peptide. I would start from there.

I've decided I'm just going to stop it, the sugars were great before starting it. And if it isn't broke don't fix it! Should have stuck to my guns. Il save it for a dieting phase

 

[MajinBoo]

I've decided I'm just going to stop it, the sugars were great before starting it. And if it isn't broke don't fix it! Should have stuck to my guns. Il save it for a dieting phase

100%! i would still question if that's mots c... maybe it's HGH

 

[Simon90]

Just following up on this...

Didn't jab mots c today. Improvement seen already back to pre mots c readings

4 meals in today and these are my post prandial readings

Fasted 4.9 (always slightly higher. Dawn phenomenon)

Meal 1
150carbs

60-90mins: 6.8
2hrs: 4.4

Meal 2
100 carbs

60-90mins: 6.6
2hrs: 4.6

Meal 3
100 carbs

60-90mins: 7
2hrs: 4.8


Meal 4
150 carbs

60-90mins: 6.8
2hrs: 4.3

 

[MajinBoo]

Just following up on this...

Didn't jab mots c today. Improvement seen already back to pre mots c readings

4 meals in today and these are my post prandial readings

Fasted 4.9 (always slightly higher. Dawn phenomenon)

Meal 1
150carbs

60-90mins: 6.8
2hrs: 4.4

Meal 2
100 carbs

60-90mins: 6.6
2hrs: 4.6

Meal 3
100 carbs

60-90mins: 7
2hrs: 4.8


Meal 4
150 carbs

60-90mins: 6.8
2hrs: 4.3

To me, if you did not inject and already saw an improvement, what you were injecting is not Mots-c.

Mots-C has a short plasma half-life but much longer at celular level. It accumulates on skeletal muscle and liver so it can modulate the metabolism. The first protocols of Mots-c were a few higher dosages shots per week - not daily.

Considering that, if it was Mots-C causing elevated glucose levels (which is the opposite of its effect), that should not change the first day you don't inject it.

 

[luki7788]

To me, if you did not inject and already saw an improvement, what you were injecting is not Mots-c.

Mots-C has a short plasma half-life but much longer at celular level. It accumulates on skeletal muscle and liver so it can modulate the metabolism. The first protocols of Mots-c were a few higher dosages shots per week - not daily.

Considering that, if it was Mots-C causing elevated glucose levels (which is the opposite of its effect), that should not change the first day you don't inject it.

100% agree

 

[Simon90]

To me, if you did not inject and already saw an improvement, what you were injecting is not Mots-c.

Mots-C has a short plasma half-life but much longer at celular level. It accumulates on skeletal muscle and liver so it can modulate the metabolism. The first protocols of Mots-c were a few higher dosages shots per week - not daily.

Considering that, if it was Mots-C causing elevated glucose levels (which is the opposite of its effect), that should not change the first day you don't inject it.

Reading more on chat gpt and troponin, this does seem to be something that can happen. In laymems terms it was basically signalling my liver to release more glucose into the bloodstream.

It was the only variable that I added, and then removed.

And I trust the source and that it is legitimately what it says it is. I do have a load of it so I could send 1 for testing but tbh I have no interest in using it again. Maybe in a prep setting.

 

[whacked]

Misc addition to this MOTS-C thread

CB4211 is an analogue of MOTS-C

“It’s a novel, modified pharmaceutical analog of the naturally occurring mitochondrial-derived peptide
MOTS-c……. to offer greater stability and potency for treating metabolic diseases like NASH and obesity. While MOTS-c regulates metabolic homeostasis, CB4211 enhances these effects by specifically acting as an insulin receptor sensitizer to reduce fat mass and improve liver”

 

[Bashmannutter]

Anyone else notice when starting mots c they had a period of time with elevated blood sugar readings?

Higher fasted, higher peaks and higher post prandial readings. Not by a small amount either we are talking 1 to 2 full points fasted and peak reading and sometimes up to 3 higher post prandial (usually 2 hours after my meal before my next u am sitting between 4 and 5 max as a norm. Now it's been as high as 7 still.

I've personally not seen anyone else talk about this online, but after asking chat gpt and troponin app, it seems normal and can be expected to last for up to 3 to 4 weeks before improvement.

For anyone interested here's a copy and paste from troponin:


MOTS-C

MOTS-C works by improving mitochondrial function and insulin sensitivity, but there's often an initial adaptation period where your body is essentially "recalibrating" its metabolic processes. Think of it like this - you're upgrading your cellular machinery, but during the installation process, things might run a bit differently than usual.

A few things could be happening:

Mitochondrial adaptation phase: Your cells are becoming more efficient at glucose uptake and utilization, but this process takes time to fully optimize
Insulin sensitivity changes: As your sensitivity improves, your body might temporarily overproduce glucose in response to what it perceives as changing insulin dynamics

Metabolic flexibility shifts: MOTS-C enhances your ability to switch between fuel sources, and during this transition, glucose regulation can be temporarily affected

Timeline and What to Expect

In my experience with clients using MOTS-C, this initial period typically lasts 2-4 weeks. Most people see their blood sugar readings normalize and then improve beyond baseline after about a month of consistent use.

Was going to DM you but posting this is likely helpful insight for others. #

This is exactly what Reta did to me, but post diet.

During dieting, reta had me crazy flat, going seriously hypo, I'd have to stop leg traning sometimes to grab some carbs. After introducing carbs I saw some of the highest readings I've had, even when I was fat. I'd also feel it, the extreme sudden highs and lows in my blood sugar.

I'd seen as high as 6.5 3hrs post meal after a medium carb beal with pletny veg, fibe and protein, even after going for a walk post meal and I use a standing desk. AAS was kept very minimal as well as peptides, only variable was introduction of carbs. This was even when I was doing fasted cardio on stepper and 12-15k steps, with kcals barely over maitenance.

I since then decided to off the reta. Couple weeks later I also tried pushing my GH from 4iu to 6iu and blood sugars went south fast. Fasted creeping upto 5.7 and again post prandial reach around 6.

Started MOTS-C last week at 1mg and also went back upto 6iu, from 4iu. Im getting below 5 practically on all my fasted and 2hr post prandial readings. Avg 4.6 in fasted morning and less than 5, between 4.6-4.9 2hrs post prandial. Also extremely noticeable
increase in energy.

I came to the same conclusion as you, but in regards to the reta, with its strong glucagon actions, I beleive it was causing my liver to overdrive and kick out glucose into my bloodstream and hence the higher BG readings. Im interested to see where my 1ac will be at come bloods, in mid march.