MOTS-c and myostatin

[micro2000]

MOTS-c reduces myostatin and muscle atrophy signaling - PMC

Keywords: FOXO1, high-fat diet, MOTS-c, muscle atrophy, myostatin

www.ncbi.nlm.nih.gov

MOTS-c is an interesting peptide.

Myostatin levels in mice can be lowered 40% with MOTS-c peptide. Studies in humans shows that MOTS-c and myostatin have an inverse relationship so it might translate to humans.

Doses in the studies translate to roughly 2.5 - 25 mg/day, with the latter dose used in the above study showing the 40% reduction in myostatin.

 

[cmryan]

MOTS-c reduces myostatin and muscle atrophy signaling - PMC

Keywords: FOXO1, high-fat diet, MOTS-c, muscle atrophy, myostatin

www.ncbi.nlm.nih.gov

MOTS-c is an interesting peptide.

Myostatin levels in mice can be lowered 40% with MOTS-c peptide. Studies in humans shows that MOTS-c and myostatin have an inverse relationship so it might translate to humans.

Doses in the studies translate to roughly 2.5 - 25 mg/day, with the latter dose used in the above study showing the 40% reduction in myostatin.

It does seem to be a heck of a peptide with many positive effects. But 25mg/day would be exorbitantly expensive. Even the cheapest value purchases from china based sources would cost ≈$20/day. So taking it for this purpose seems a bit unrealistic for meatheads like us. But for people with muscle wasting diseases, it may indeed be a viable option. Lord only knows how much a pharma company would charge for it though.

 

[micro2000]

It does seem to be a heck of a peptide with many positive effects. But 25mg/day would be exorbitantly expensive. Even the cheapest value purchases from china based sources would cost ≈$20/day. So taking it for this purpose seems a bit unrealistic for meatheads like us. But for people with muscle wasting diseases, it may indeed be a viable option. Lord only knows how much a pharma company would charge for it though.

You're right that it is expensive for this dosing but MOTS-c is one of the cheaper peptides to hit the market and if it becomes more popular I expect the price to drop.

Ive seen 10 x 15mg vials for less than $100. Pricey but hopefully will come down.

 

[TomJ]

Im not sold that myostatin plays all that big of a limiting role in most people.
maybe for the top1% that have literally everything dialed in perfect (Training, nutrition, recovery, peds, ect) while also having FFMI of 30+

for most of the rest of the intermediate competitors and gym bros i think addressing other limitors is probably going to have a larger impact

 

[M@NU]

ive bought 190mg of mots-c for my upcoming triceps tendon surgery.
will use it 10 days @ 10mg and 18 days @ 5mg, so comes out to 4 weeks
will see

 

[micro2000]

ive bought 190mg of mots-c for my upcoming triceps tendon surgery.
will use it 10 days @ 10mg and 18 days @ 5mg, so comes out to 4 weeks
will see

Any reason for choosing this peptide for surgery recovery?

 

[M@NU]

there are several studies showing it can blunt muscle atrophy. e.g. https://pubmed.ncbi.nlm.nih.gov/38170165/
i was hoping this + cross educational effect (training the opposite side) will leave atrophy to a minimum.
and then bpc + tb + hgh high dosed for a speedy recovery

 

[lifter]

there are several studies showing it can blunt muscle atrophy. e.g. https://pubmed.ncbi.nlm.nih.gov/38170165/
i was hoping this + cross educational effect (training the opposite side) will leave atrophy to a minimum.
and then bpc + tb + hgh high dosed for a speedy recovery

IMO, no harm in trying mots-c. If it helps you, great, if it doesn't, at least you tried and you can relay your experience either way.

I also trained the opposite arm but I was not looking to go heavy with it. A few weeks after getting my splint off, I started iso on the other arm with very low weight and slowly worked up until I worked movements with both arms at the same time (I believe after 2 weeks).

 

[jstrong20]

Im not sold that myostatin plays all that big of a limiting role in most people.
maybe for the top1% that have literally everything dialed in perfect (Training, nutrition, recovery, peds, ect) while also having FFMI of 30+

for most of the rest of the intermediate competitors and gym bros i think addressing other limitors is probably going to have a larger impact

Based on the animals with mutations and even one human I think it does. The problem I was guessing is you need something that does it to an extreme degree. Same way natty test booster and clomid do work to rais test but not enough to make huge changes. This was just my guess though and I'm not a scientist. Lol. Still intrestong to learn about though and see if anything every pans out..

 

[lifter]

Based on the animals with mutations and even one human I think it does. The problem I was guessing is you need something that does it to an extreme degree. Same way natty test booster and clomid do work to rais test but not enough to make huge changes. This was just my guess though and I'm not a scientist. Lol. Still intrestong to learn about though and see if anything every pans out..

Most here aren't scientists. They guess just like you. Your opinion is just as valid as any other with the unknown as in this case.

 

[M@NU]

IMO, no harm in trying mots-c. If it helps you, great, if it doesn't, at least you tried and you can relay your experience either way.

I also trained the opposite arm but I was not looking to go heavy with it. A few weeks after getting my splint off, I started iso on the other arm with very low weight and slowly worked up until I worked movements with both arms at the same time (I believe after 2 weeks).

i wont be able to go heavy either due to missing bracing from my right arm but i think it is good for my mental health is i train half of my upper body and not just legs^^.
docs told me splint has to be worn for 6 weeks.This is also the timeframe when the tendon is weak and should be treated with absolute care

 

[cmryan]

You're right that it is expensive for this dosing but MOTS-c is one of the cheaper peptides to hit the market and if it becomes more popular I expect the price to drop.

I hope you're correct b/c I do think it's an outstanding product.

Ive seen 10 x 15mg vials for less than $100. Pricey but hopefully will come down.

Yeah, aside from promo offers, that's about the best pricing I've seen for it.

 

[01dragonslayer]

MOTS-c reduces myostatin and muscle atrophy signaling - PMC

Keywords: FOXO1, high-fat diet, MOTS-c, muscle atrophy, myostatin

www.ncbi.nlm.nih.gov

MOTS-c is an interesting peptide.

Myostatin levels in mice can be lowered 40% with MOTS-c peptide. Studies in humans shows that MOTS-c and myostatin have an inverse relationship so it might translate to humans.

Doses in the studies translate to roughly 2.5 - 25 mg/day, with the latter dose used in the above study showing the 40% reduction in myostatin.

Thanks for posting this. I have some Mots on the way.

 

[Mayhem]

Thanks for posting this. I have some Mots on the way.

Any updates and feedback?