Mots-C anyone tried it ?

[Virtues]

Very interesting.

Question - when you were taking large doses 10mg or so MOTS-C did you notice any energy from it?

I recall the effects on your blood glucose but didnt see you mention along those lines.

oops wrong reply

 

[Virtues]

Everyone can say what they want, believe it or not, but I’ll just share my experience. My cystatin C and GGT, related to kidney and liver function, wouldn’t drop below a certain level for about nine/ten months. They were close to the normal range, but still slightly above, even though everything else was already fine.

Only after I introduced retatrutide and MOTS-c did those markers finally return to normal. And not just barely, but right into the middle of the range.
Maybe it was because of that, maybe not. But for me, the timing is clear. I’ll keep using them.

Im dealing with issues with my Kidney function. Im currently on Reta. What was ur Motsc schedule/dosage?
I'm glad it helped you out.

 

[Massive G]

Did the ss31 make a big difference when stacked with Mots-c?

Yes as far as recovery wise for the heart ..I have been hitting it very hard lately intense training and hit cardio and it has made a difference in that area for me.
I believe you have to define your own protocols and dosing based on what the peptide or drug does. Too many goddamn gurus and experts out there.

 

[Massive G]

Im dealing with issues with my Kidney function. Im currently on Reta. What was ur Motsc schedule/dosage?
I'm glad it helped you out.

What type of kidney issues? SS-31 has very positive effects on the kidneys as well as the heart.

 

[Virtues]

What type of kidney issues? SS-31 has very positive effects on the kidneys as well as the heart.

I recently ordered SS-31. I have routine labs at the VA every 3 to 5 months, and my kidney function has been fluctuating. In the past, I was hospitalized due to kidney stones, and my kidney function dropped significantly.

 

[Sully1234]

To all the Dr Trevor haters - he is vindicated here (in link). Lol

He is an abrasive egomanic.

However, to his credit; he was pretty much the only one screaming MOTS-C first (or concurrently) then SS-31 for over a year; and got a lot of flack for it.

Ps. Approximately 11 minutes in, this guy discusses the lack of a requirement for cycling due to receptor desensitization, although it still seems to be prudent.

Thank you for posting.

Cliff notes on dosing for anyone too lazy to watch these videos like I usually am:

SS-31
4mg daily showed same benefits as 40mg daily in a study
3-4mg likely max effective dose
Speakers optimization dose is generally 2mg per day
Save your money

MOTS-C
Dosing 3x per week maintained all measurable benefits
5-15mg per week
Speaker recommends 10mg spread through week
Peptide has short half life but works through gene expression so works after peptide has cleared

Would be nice is there was a similar MOTS-c study comparing say 3mg per day vs 30mg

 

[Massive G]

Thank you for posting.

Cliff notes on dosing for anyone too lazy to watch these videos like I usually am:

SS-31
4mg daily showed same benefits as 40mg daily in a study
3-4mg likely max effective dose
Speakers optimization dose is generally 2mg per day
Save your money

MOTS-C
Dosing 3x per week maintained all measurable benefits
5-15mg per week
Speaker recommends 10mg spread through week
Peptide has short half life but works through gene expression so works after peptide has cleared

Would be nice is there was a similar MOTS-c study comparing say 3mg per day vs 30mg

SS-31 is approved by the FDA and marketed as Forzinity. It treats a rare mitochondrial disorder defined as barths syndrome. I think from past research there are only like 6000 cases and the treatment cost 800K a year. Yes lots of studies out there for the heart and kidneys as well. Mots c you will probably not find official studies on humans with it. There are reports of anaphylaxis at doses of 5 mg and above. So tread carefully. I have had good results with 3 mg a day on mots-c and keeping steady at 4mg a day of SS-31.

 

[Sully1234]

I am doing 3 mgs Mots-C am and 3 mgs SS31 pm

Feel absolutely fantastic.

I'm really enjoying the SS-31 and MOTS-C combo too. I'm doing 3mg each in the AM. Mid morning slumps and fatigue are non existent, focus is better, way less brain fog

Any reason in particular you like seperate AM/PM dosing or just trying things out?

 

[Massive G]

I'm really enjoying the SS-31 and MOTS-C combo too. I'm doing 3mg each in the AM. Mid morning slumps and fatigue are non existent, focus is better, way less brain fog

Any reason in particular you like seperate AM/PM dosing or just trying things out?

Mots-C amps me up. SS31 doesn't . Use one to stimulate and one to recover.

 

[Rainmanisback]

MOTS-c is a mitochondrial-derived peptide that acts as a systemic signaling molecule to reduce myostatin, a protein that limits muscle growth. By inhibiting myostatin expression and reducing muscle atrophy, MOTS-c promotes muscle growth, improves insulin sensitivity, and acts as an exercise mimetic.
National Institutes of Health (.gov)

Key Connections Between MOTS-c and Myostatin:
Reduced Myostatin Levels: Studies show MOTS-c administration can lead to a 40% reduction in myostatin in rodents.
Preventing Muscle Loss: MOTS-c blocks obesity-induced muscle atrophy and promotes muscle metabolism.
Mechanism of Action: MOTS-c inhibits the FOXO1 pathway, an upstream regulator of myostatin and muscle wasting.
Direct Interaction: Research indicates MOTS-c binds to CK2, a kinase that regulates myostatin signaling pathways in muscle tissue.
National Institutes of Health (.gov)

Therapeutic Potential:
Combating Sarcopenia: MOTS-c is being investigated as a therapy for age-related muscle loss and muscle-wasting conditions.
Obesity and Diabetes: By decreasing myostatin and improving insulin sensitivity, MOTS-c shows promise for metabolic syndrome, particularly when paired with exercise.

In human studies, plasma levels of MOTS-c are inversely correlated with circulating myostatin levels, suggesting a natural role in maintaining muscle mass.

 

[Simon90]

Would using mots c and igf lr3 in the same Cycle be pointless due to AMPK activation blunting mTOR signalling or that just an overly simplistic generalisation and there's more to it than that?

 

[Sully1234]

Would using mots c and igf lr3 in the same Cycle be pointless due to AMPK activation blunting mTOR signalling or that just an overly simplistic generalisation and there's more to it than that?

I think with with the gear and peptides and GH most of these signals that in a normal setting would stop or get shut down are pretty easily overriden.

 

[luki7788]

Would using mots c and igf lr3 in the same Cycle be pointless due to AMPK activation blunting mTOR signalling or that just an overly simplistic generalisation and there's more to it than that?

I always like to use this analogy. Worrying about things like that is like driving a Ferrari at 300 km/h and being concerned that a mosquito hitting your headlight might slow you down. LOL.

It’s a funny comparison, but I think it fits. There’s really no point stressing over things like that. And remember, we’re enhanced athletes, so our biochemistry and physiology work quite differently compared to natural athletes.

 

[Ranchhand]

And remember, we’re enhanced athletes, so our biochemistry and physiology work quite differently compared to natural athletes.

exactly, exogenous signaling works very different than endogenous signaling.

 

[Bashmannutter]

I always like to use this analogy. Worrying about things like that is like driving a Ferrari at 300 km/h and being concerned that a mosquito hitting your headlight might slow you down. LOL.

It’s a funny comparison, but I think it fits. There’s really no point stressing over things like that. And remember, we’re enhanced athletes, so our biochemistry and physiology work quite differently compared to natural athletes.

Hi Luki, can I please ask you mate, have you or your clients noticed disturbed sleep from Mots-C? I've found the last few weeks my sleep quality has taken a nose dive, with Mots-c being the only addition and variable in the last month.

 

[luki7788]

Hi Luki, can I please ask you mate, have you or your clients noticed disturbed sleep from Mots-C? I've found the last few weeks my sleep quality has taken a nose dive, with Mots-c being the only addition and variable in the last month.

Personally, no. And based on the mechanism of action, MOTS-C should rather improve sleep, not worsen it.

It helps stabilize and optimize mitochondrial function, and mitochondria are also involved in circadian rhythm. So in theory and in practice, it should even improve sleep.

I can say for myself I feel an overall improvement in how my body functions, and a lot of people report the same.
But when it comes to that “energy boost” people talk about 1–2 hours after injection I don’t feel it at all. In my opinion, it’s more likely placebo. But since so many people report it, it’s hard to completely ignore.
Personally, I just don’t feel it.

The only person I know report worse sleep was John Jewett on his forum. I even talked to him about it. I suggested that MOTS-C should rather help, but he said there were too many variables at that time to be sure. So he stopped using it to see what happens.

As he said himself too many things were changing at once, so it could have been coincidence, not directly caused by MOTS-C.
Hard to say maybe it’s an individual reaction, or maybe something related to solvents in the product.

But overall, based on how it works, MOTS-C should improve sleep, not make it worse.

 

[megroo]

Has anyone experienced skin irritation from mots c at all?

I don’t mean around the injection site- I’m talking about an all over tingling/itchy sunburn type feeling.

Similar to what some people have experienced with Reta

I’ve never had it myself from Reta- but since recently adding in some mots c for the first time, this has begun.

 

[Bashmannutter]

Personally, no. And based on the mechanism of action, MOTS-C should rather improve sleep, not worsen it.

It helps stabilize and optimize mitochondrial function, and mitochondria are also involved in circadian rhythm. So in theory and in practice, it should even improve sleep.

I can say for myself I feel an overall improvement in how my body functions, and a lot of people report the same.
But when it comes to that “energy boost” people talk about 1–2 hours after injection I don’t feel it at all. In my opinion, it’s more likely placebo. But since so many people report it, it’s hard to completely ignore.
Personally, I just don’t feel it.

The only person I know report worse sleep was John Jewett on his forum. I even talked to him about it. I suggested that MOTS-C should rather help, but he said there were too many variables at that time to be sure. So he stopped using it to see what happens.

As he said himself too many things were changing at once, so it could have been coincidence, not directly caused by MOTS-C.
Hard to say maybe it’s an individual reaction, or maybe something related to solvents in the product.

But overall, based on how it works, MOTS-C should improve sleep, not make it worse.

Thanks mate, appreciate the detailed reponse. For me Im very certain it was the culprit. Maybe my dosing shcedule could be the issue as I was using 1mg ED.

Its been absolutely fantastic at keeping my fasted and post prandial BG in a great spot, especially whilst using 7iu GH which is the most I've ever used. Before dropping it, I did introduce SLU-PP 332 brieflly for the week and that def worked well together. I actually found myself going hypo occasionaly.

I feel they are 2 fantastic peptides for improving insulin sensitivity.

 

[luki7788]

Has anyone experienced skin irritation from mots c at all?

I don’t mean around the injection site- I’m talking about an all over tingling/itchy sunburn type feeling.

Similar to what some people have experienced with Reta

I’ve never had it myself from Reta- but since recently adding in some mots c for the first time, this has begun.

Yes - after the injection there is a slight burning sensation for a few minutes, but it is so slight that I don't even bother with it.

 

[luki7788]

Thanks mate, appreciate the detailed reponse. For me Im very certain it was the culprit. Maybe my dosing shcedule could be the issue as I was using 1mg ED.

Its been absolutely fantastic at keeping my fasted and post prandial BG in a great spot, especially whilst using 7iu GH which is the most I've ever used. Before dropping it, I did introduce SLU-PP 332 brieflly for the week and that def worked well together. I actually found myself going hypo occasionaly.

I feel they are 2 fantastic peptides for improving insulin sensitivity.

Also it’s strange that MOTS-C caused sleep problems for you, but SLU didn’t.

In theory, it should be the opposite. MOTS-C doesn’t directly affect metabolism, while SLU increases mitochondrial activity not just optimizes it, but really pushes it higher.
So that means faster metabolism, and that can actually cause sleep issues. A lot of people report worse sleep on SL-PPP332.

So it’s a bit strange. But maybe it’s just an individual reaction - hard to say.