My first Dexa Scan vs my Renpho Smart scale

[yellowbird1]

I didn’t even know about this component (low estrogen reducing bone density) until you mentioned it.

I appreciate the insight

Low e2 is a problem yes but which AI is just as important because anastrozole is bone catabolic while exemestane is bone anabolic.

 

[Siggy]

Low e2 is a problem yes but which AI is just as important because anastrozole is bone catabolic while exemestane is bone anabolic.

According to GPT, exemestane also decreases bone density.

 

[SouthernMuscle]

According to GPT, exemestane also decreases bone density.

If you guys are truly concerned about bone density, take 45mg of mk4 daily. Ideally split 3x per day with a fat containing meal.

Run that through any AI with all other factors like estrogen suppression, AAS use , resistance training etc and I think you’ll be pleased with the answers

 

[Sammy_J]

Has anyone used a Hume body scale and compared it to a Dexa scan? I have the Hume body, I’m sure the numbers are off as well. But it’s pretty solid at showing the trends I think. As long as I take the measurements first thing in the morning, I never see any large deviations from the previous measurement.

 

[yellowbird1]

According to GPT, exemestane also decreases bone density.

I think AI will doom us all. Of course it says it will decrease if you use an amount like 25mg daily to crush estrogen like women do in most of the studies. I think AI will say anything to make you happy. I got it to say the opposite


Before type-iix was banned here he had this clip from a larger PowerPoint on estrogen management. You can view the entire presentation if you are a member of his substack

 

[SouthernMuscle]

Of course it says it will decrease if you use an amount like 25mg daily to crush estrogen like women do in most of the studies.

Why would you not take 25mg if you’re taking grams of test

 

[Siggy]

I think AI will doom us all. Of course it says it will decrease if you use an amount like 25mg daily to crush estrogen like women do in most of the studies. I think AI will say anything to make you happy. I got it to say the opposite
View attachment 249521

Before type-iix was banned here he had this clip from a larger PowerPoint on estrogen management. You can view the entire presentation if you are a member of his substack

It says exemstane has been shown to increase bone density in cells and rats, so in a petri dish and in rodents.

To be fair, most of the studies showing exemstane reduces bone density in humans has been done on women, not men.

 

[yellowbird1]

Why would you not take 25mg if you’re taking grams of test

Because of it's suicide inhibition your dose of exemestane stays the same whether you run 500mg test or 1g test or 2g test, etc.. For me it's 25mg Monday and 12.5mg Thursday. Keeps my e2 at 30. I've considered cutting the 25mg dose in half to let e2 come up higher

 

[yellowbird1]

It says exemstane has been shown to increase bone density in cells and rats, so in a petri dish and in rodents.

To be fair, most of the studies showing exemstane reduces bone density in humans has been done on women, not men.

True. And in those women they are using if at doses to crush estrogen so it is tough to know just how bone anabolic it could be. Either way I pick it over arimidex because theoretically it should affect bone less and have less hair loss and effect on igf1.

 

[SouthernMuscle]

Because of it's suicide inhibition your dose of exemestane stays the same whether you run 500mg test or 1g test or 2g test, etc..

are you saying that one certain dose, dependent on the individual, will work no matter if he takes 500mg of test a week or 2000mg test a week?

 

[yellowbird1]

are you saying that one certain dose, dependent on the individual, will work no matter if he takes 500mg of test a week or 2000mg test a week?

Yeah once you've reached steady state. So 200mg might be too low but 500mg+ it should theoretically stay the same e2 no matter how much test you use

 

[Siggy]

True. And in those women they are using if at doses to crush estrogen so it is tough to know just how bone anabolic it could be. Either way I pick it over arimidex because theoretically it should affect bone less and have less hair loss and effect on igf1.

Dont kid yourself, theres no study or scenario in which exemstane is going to be bone anabolic in humans. We arent rats or cells in a petri dish.

 

[Siggy]

Yeah once you've reached steady state. So 200mg might be too low but 500mg+ it should theoretically stay the same e2 no matter how much test you use

My E2 is doubled every time I have doubled my Test dose all the way up to 1000MG ( I have never been over 1000MG)

 

[SouthernMuscle]

Yeah once you've reached steady state. So 200mg might be too low but 500mg+ it should theoretically stay the same e2 no matter how much test you use

Did a lil deep dive because I never really explored the mechanism despite having taken exemestane for at least a decade.

You’re absolutely right that the percentage of aromatase inhibition holds across any test dose.

I did find however that absolute e2 level will not stay the same across all test doses due to estrogen conversion from the small uninhibited enzyme pool + ongoing new enzyme synthesis.
Those two factors are person specific though

Interesting shit!

 

[TeknoViking]

If you guys are truly concerned about bone density, take 45mg of mk4 daily. Ideally split 3x per day with a fat containing meal.

Run that through any AI with all other factors like estrogen suppression, AAS use , resistance training etc and I think you’ll be pleased with the answers

How long do people typically run this for bone density?

 

[SouthernMuscle]

How long do people typically run this for bone density?

So from what I’ve read it only improves bone density as long as you’re supplementing it. When you’re taking it, it’s activating osteocalcin, so osteocalcin can bind to your bones, then grab calcium from your bloodstream and lock it into the bone matrix.
When you stop taking it, this cascade stops.

They’ve done mega studies on it with thousands of people. Mostly post menopausal women because they were studying it for fracture prevention.

In short, the people studied were basically gonna take it indefinitely