Natural Prolactin Control

[need4tren]

If you use P5P far enough before starting the compounds you usually can avoid using Caber sometimes. 150mg is plenty for most.

But if that doesn’t work then use Caber 2 times a week at a very low dose.

Most guys get into trouble when they think “more is better” when it comes to things like Caber.

from what I’ve read high dose p5p for prolonged periods can be toxic?

Excellent. Will up my dose. Do you split doses or all at once?

First couple days I do 300 morning and night. Then I do 300mg a day till a bottle is gone I just run one bottle from Aor brand p5p

 

[bbxtreme]

from what I’ve read high dose p5p for prolonged periods can be toxic?

First couple days I do 300 morning and night. Then I do 300mg a day till a bottle is gone I just run one bottle from Aor brand p5p

Potential neuropathy if taken too long or at too high of dosages. It does take a substantial amount for that as it’s a water soluble b vitamin.

I would be much more worried about long term use of caber.

Office of Dietary Supplements - Vitamin B6

Vitamin B6 (pyridoxine) overview for health professionals. Research health effects, dosing, sources, deficiency, side effects, and interactions here.

ods.od.nih.gov

 

[AllOkJumpmaster]

Google inhibit-P from SNS nutrition

best product on the market for natty's imo

 

[LATS]

300mg b6.. dropped my prolactin to 7..

 

[dimethyl11]

Why p5p over “regular” b6 (pyroxidine hcl)?

 

[Stewie]

Why p5p over “regular” b6 (pyroxidine hcl)?

Pyridoxine hydrochloride (inactive form) has to be converted to the cofactor (coenzyme) pyridoxal-5′-phosphate (active form p5p). Which then further catalyzes the decarboxylation of L-DOPA to dopamine. There's several steps involved, this is the simplicity of it.

There's some belief that pyridoxine can inhibit pyridoxal-5′-phosphate enzymatic transcription.

https://www.sciencedirect.com/science/article/abs/pii/S0887233317301959?via%3Dihub

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Highlights
•Pyridoxine is the toxic form of vitamin B6.

•Neuronal cells are sensitive to the toxic effects of pyridoxine.

•The inactive form PN competitively inhibits the active PLP.

•Symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

 

[dimethyl11]

Pyridoxine hydrochloride (inactive form) has to be converted to the cofactor (coenzyme) pyridoxal-5′-phosphate (active form p5p). Which then further catalyzes the decarboxylation of L-DOPA to dopamine. There's several steps involved, this is the simplicity of it.

There's some belief that pyridoxine can inhibit pyridoxal-5′-phosphate enzymatic transcription.

https://www.sciencedirect.com/science/article/abs/pii/S0887233317301959?via%3Dihub

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Highlights
•Pyridoxine is the toxic form of vitamin B6.

•Neuronal cells are sensitive to the toxic effects of pyridoxine.

•The inactive form PN competitively inhibits the active PLP.

•Symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

In conclusion, the present study indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-5′-phosphate. Consequently, symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency.

Great thanks @Stewie for breaking that down for me

 

[buck]

300mg b6.. dropped my prolactin to 7..

1 dose or spread out?

 

[LATS]

1 dose or spread out?

One dose.. that is what the studies did and the actual half life is fairly long

 

[hogan87]

I read a study showing p5p was as effective as caber! I used bromocriptine once for prolactin and had an absent seizure. Basically blacked out while my wife was talking to me. Tunnel vision, sweats, did not hear anything, then just came back 20 seconds later. Only time it ever happened to me. No mo bromo

 

[Neuro1234]

Checking your NLR (neutrophil-lymphocyte ratio). Basically teasing out the possibility of unsuspected inflammation/infection. Being that your work in ICU (thank you very much I have two children that are RN's). You're more susceptible than the general population to acquire whatever pathogen might be floating around, without symptoms so to speak.

Prolactin functions in a dual manner, as a tropic hormone and a type of cytokine- immunomodulator. In the context of inflammatory response, prolactin can transiently and acutely rise. I've personally seen several individuals with acute changes in their PRL due to infections/systematic inflammation. They were chasing the wrong cause.

Then again, it could totally unrelated to the aforementioned.

NLR was elevated only on two of the labs draws but did correlate with the most elevated numbers. Thank you very much for this valuable information. Will always keep an eye on this moving forward given my career path, as you mentioned. Thanks again.