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new thoughts on estrogen control

I agree completely. I believe each man has a ratio of E2:T that works best for them.

For me, I feel best at E2 around 20-30 on TRT, so (for example) if I were to run 1G of test, estrogen doesn't cause me issues unless it gets outside of my 'normal' TRT T:E2 ratio.

I am no doc, but this is my personal experience.


ALSO, E2 versus the other estrogens would be a good study, we know estradiol is the strongest, but how do the other estrogens affect us physically and mentally?

Also the fact that AIs often greatly increase other "inactive" estrogens would be interesting to know the full effect of.

Aren't there something like 17 estrogens?
 
https://www.steroidal.com/steroids-side-effects/estrogen/

ERa and ERb are important subtypes to learn. They sometimes have opposite effects in tissues and in cancerous tissue.

For example, ERa is generally considered responsible for enhanced proliferation in breast cancers, whereas this is counteracted by the presence of ERb, which exerts an antiproliferative effects. This is also seen in prostate cancer, where ERb has an antiproliferative and pro-apoptotic effect.
 
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Aren't there something like 17 estrogens?

There are 4 different estrogens, E1, E2, E3, and E4. Taking AIs lowers E2 and increases E1 or E3, I forget which.

https://www.steroidal.com/steroids-side-effects/estrogen/

ERa and ERb are important subtypes to learn. They sometimes have opposite effects in tissues and in cancerous tissue.

For example, ERa is generally considered responsible for enhanced proliferation in breast cancers, whereas this is counteracted by the presence of ERb, which exerts an antiproliferative effects. This is also seen in prostate cancer, where ERb has an antiproliferative and pro-apoptotic effect.

These are types of estrogen receptors in addition to the different types of estrogens.
 
Over 3 yrs old but Serrano is saying keep e2 70 or under and also definitely warns about crushing estrogen levels too low.

[ame="https://www.youtube.com/watch?v=trR5MmkLkUo"]Serrano Says- quick thoughts on estrogen management - YouTube[/ame]
 
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There are 4 different estrogens, E1, E2, E3, and E4. Taking AIs lowers E2 and increases E1 or E3, I forget which.



These are types of estrogen receptors in addition to the different types of estrogens.

Adults don't synthesis Estetrol (E4). It's only during gestational stages is it hepatically produced by estradiol (E2) and estriol (E3) from the fetus by two isotype enzymes-->15a-hydroxylase and 16a-hydroxylase in which subside to be active after birth. Only the mother and fetus have circulating E4. You and I, not a chance.
 
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Adults don't synthesis E4. It's only during gestational stages is it hepatically produced by the fetus by two isotype enzymes-->15a-hydroxylase and 16a-hydroxylase in which subside to be active after birth. Only the mother and fetus have circulating E4. You and I, not a chance.

Good clarification, I wasn't suggesting we do, just talking theoretically about the different types of estrogen.
 
There is a boogie man in this that goes beyond estrogen. Many users see water retention and assume the culprit is high estrogens. The reality is it can also be in part from aberrant mineralocorticoid signaling. It is know that most steroids alter this signaling for instance buy interfering with aldosterone signaling. This is specially the case as the dose increases.

Some users may take AIs thinking they are addressing high estrogen issues when the real situation is altered mineral balance and related water retention.

What would you use to combat this? Pretty much every aas I have used has caused me bloat/water retention.
 

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