Omega-3 decreases muscle gains w/tren?

[BigTex]

What do you guys think about this study?

1: J Anim Sci. 2003 Dec;81(12):3028-34. Links

Effects of flax supplementation and a combined trenbolone acetate and estradiol implant on circulating insulin-like growth factor-I and muscle insulin-like growth factor-I messenger RNA levels in beef cattle.

Dunn JD, Johnson BJ, Kayser JP, Waylan AT, Sissom EK, Drouillard JS.
Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, USA.

We evaluated effects of a 5% (dry matter basis) ground flaxseed supplement (flax) and a trenbolone acetate and estradiol-17beta implant, Revalor-S, on circulating IGF-I and muscle IGF-I messenger RNA (mRNA). Sixteen crossbred yearling steers (initial BW = 397 kg) were assigned randomly to one of four treatments: 1) flax/implant; 2) nonflax/implant; 3) flax/nonimplant; and 4) nonflax/nonimplant. Serum was harvested from blood collected on d 0 (before implant or flax addition), 14, and 28, and used in subsequent analyses of circulating IGF-I. Biopsy samples (0.5 g) were obtained from the longissimus muscle on d 0, 14, and 28. Total RNA was isolated from the muscle samples, and real-time quantitative-PCR was used to assess relative differences in IGF-I mRNA. Flax supplementation had no effect (P > 0.10) on circulating IGF-I concentrations. Following implantation, sera from implanted steers had 52 and 84% greater (P < 0.05) IGF-I concentrations than sera from nonimplanted steers on d 14 and 28, respectively. On d 28, local muscle IGF-I mRNA levels increased 2.4-fold (P < 0.01) in biopsy samples obtained from implanted compared with nonimplanted steers. Muscle biopsy samples from nonflax cattle had 4.4-fold higher (P < 0.01) levels of IGF-I mRNA than those from flax cattle on d 28. To determine whether a component of flax, alpha-linolenic acid (alphaLA), was directly responsible for IGF-I mRNA down-regulation, we incubated primary cultures of bovine satellite cells, from implanted and nonimplanted steers, in two concentrations of alphaLA (10 nM and 1 microM). An implant x dose interaction (P < 0.05) was observed for IGF-I mRNA concentrations in bovine satellite cells cultured for 72 h with alphaLA. Satellite cells from nonimplanted steers had similar (P > 0.10) IGF-I mRNA concentration regardless of the level of alphaLA exposure; however, satellite cells from implanted steers exposed to 10 nM and 1 microM alphaLA had 2.5- and 2.0-fold greater IGF-I mRNA levels, respectively, than cells from implanted steers that were not exposed to alphaLA (P < 0.05). Administration of a Revalor-S implant increased circulating IGF-I and local muscle IGF-I mRNA concentrations in finishing cattle. However, muscle IGF-I mRNA levels were decreased by flax supplementation. Muscle cell culture experiments suggested that alphaLA was not responsible for the IGF-I mRNA down-regulation.

Here is what they are claiming: Flax seed oil lowers muscular IGF-I and IGF-I rna, and decreases the mass gain with tren pellets by about 10%. Ironically, Flax alone increases mass gain compared to control.

Full study here:
**broken link removed**

 

[Mr_Magoo]

well, u should really be doing omega 3 fish oil, and i've seen studies where because of how well it lowers inflamation it can interfee with muscle gain but I have never found it to interfere with my growth

 

[PHIL HERNON]

FLAX

WHY ANYONE WOULD EVER USE FLAX IS BEYOND ME....I TELL MY CLIENTS TO STAY AWAY FROM IT.........FOR THE PAST 5 YEARS STUDIES HAVE SHOWN PROBLEMS ARISING FROM ITS USE.........SPECIFICALLY CONVERSION TO ARACIDONIC ACID.

 

[NPCS FINEST]

WHY ANYONE WOULD EVER USE FLAX IS BEYOND ME....I TELL MY CLIENTS TO STAY AWAY FROM IT.........FOR THE PAST 5 YEARS STUDIES HAVE SHOWN PROBLEMS ARISING FROM ITS USE.........SPECIFICALLY CONVERSION TO ARACIDONIC ACID.

I had a few studies saved to my old PC but it got tossed out before I could resave them. I wish I still had them. I did'nt mine stopping its use because honestly the taste was about all I could stand.

 

[VTliftVT]

well, u should really be doing omega 3 fish oil, and i've seen studies where because of how well it lowers inflamation it can interfee with muscle gain but I have never found it to interfere with my growth

MD published exactly what you described...ill look for the study...not sure where the tren part comes in tho

 

[Mr_Magoo]

WHY ANYONE WOULD EVER USE FLAX IS BEYOND ME....I TELL MY CLIENTS TO STAY AWAY FROM IT.........FOR THE PAST 5 YEARS STUDIES HAVE SHOWN PROBLEMS ARISING FROM ITS USE.........SPECIFICALLY CONVERSION TO ARACIDONIC ACID.

thats news to me, what aout flax seed meal as it's high in fiber