Opinion on Bloodwork

[M@NU]

Hey guys,
i just had bloodwork on friday while being on "cruise" since 3 weeks, so the esters havent cleared yet.
Cruise is still somewhat a blast for most, its 300T/300Primo/140npp
I also used 25mg Var and/or 20mg anadrol 4 days of the week.
HGH always between 10 and 14iu daily

i had a doc appontment due to low bloodpressure lately since reducing the dosage and being more active + introducing low dose reta and mots c (97/56) and wanted their opinion which medication to reduce. I wanted to do Bloodwork but usually its an extra appointment.
So i was slightly dehydrated at the time of BW (i drank around 0,4L this morning which is quite low for my standards)
ProBNP is slightly elevated which is known (heart insufficience)

My opinion:
all in all, it is what ive expected. not overwhelming good but no full catastrophy
My creatinine is slightly elevated, probably due to slight dehydration. Same for HCT and HB.
Cystatine C is the one which is worrying me the most since 2023 it was 0,91, last time it was 1.02 and now its 1.14. Slight increase but the reference range is up to 1,44 so still in range. Will probably try to get an appointment for a kidney ultrasound though.
HDL was expected, LDL is good and ratio is also good. Though i should drop the orals and bring HDL up.
Thyroid slightly hyper, might reduce L-Thyroxin a bit.
GPT elevated due to training bacK/legs the day before.
HBA1C good

whats your opinion?
thanks alot!

 

[M@NU]

noone?

 

[massephase]

the reference range is up to 1,44

Interesting. My lab has the reference range of 0.61 - 0.95. Do they just make them up? This is from Bioscientia in Germany.

 

[M@NU]

Interesting. My lab has the reference range of 0.61 - 0.95. Do they just make them up? This is from Bioscientia in Germany.

mine is blackholm

 

[luki7788]

Interesting. My lab has the reference range of 0.61 - 0.95. Do they just make them up? This is from Bioscientia in Germany.

European norms are totally different than those in the USA - there is a greater margin of tolerance there because the US society is definitely more "unhealthy" than in Europe.

 

[luki7788]

Hey guys,
i just had bloodwork on friday while being on "cruise" since 3 weeks, so the esters havent cleared yet.
Cruise is still somewhat a blast for most, its 300T/300Primo/140npp
I also used 25mg Var and/or 20mg anadrol 4 days of the week.
HGH always between 10 and 14iu daily

i had a doc appontment due to low bloodpressure lately since reducing the dosage and being more active + introducing low dose reta and mots c (97/56) and wanted their opinion which medication to reduce. I wanted to do Bloodwork but usually its an extra appointment.
So i was slightly dehydrated at the time of BW (i drank around 0,4L this morning which is quite low for my standards)
ProBNP is slightly elevated which is known (heart insufficience)

My opinion:
all in all, it is what ive expected. not overwhelming good but no full catastrophy
My creatinine is slightly elevated, probably due to slight dehydration. Same for HCT and HB.
Cystatine C is the one which is worrying me the most since 2023 it was 0,91, last time it was 1.02 and now its 1.14. Slight increase but the reference range is up to 1,44 so still in range. Will probably try to get an appointment for a kidney ultrasound though.
HDL was expected, LDL is good and ratio is also good. Though i should drop the orals and bring HDL up.
Thyroid slightly hyper, might reduce L-Thyroxin a bit.
GPT elevated due to training bacK/legs the day before.
HBA1C good

whats your opinion?
thanks alot!

Ok, quick analysis, what I would say about it:
Kidneys (creatinine, cystatin C, eGFR)
Creatinine can be higher because of muscle mass, hard training and a bit of dehydration, I agree.
But cystatin C is going up over time, and that matters more than one single result. Also eGFR around 56 does not look like just “noise”. It’s not a disaster yet, but it’s not a clean card either. Good idea with ultrasound. I would also add urine check (albumin/creatinine ratio) and repeat cystatin after a few days with no hard training and with good hydration.

Liver (ALT/GPT)
ALT around 180 is probably not only from back day or leg day. With Var + Anadrol this is a very typical picture. GGT is low, so it does not look like real demage, but the liver is getting hit. I would seriously consider dropping the orals, at least for some time.

Lipids
LDL and TG look fine, but HDL 12 is very low. Classic when you use orals and heavy androgen load. Good LDL does not “fix” that. If you cut something first, again, cut the orals.

Blood (Hb, HCT)
Hemoglobin and hematocrit are higher, but not crazy yet. Dehydration can push it too. Keep hydration on point and watch if HCT keeps going up.

Thyroid
TSH low, fT3/fT4 high-normal. Looks like mild “pharma hyper”, so lowering L-thyroxine dose makes sense. Your read here is ok.

ProBNP
If you have history of heart issues, BNP at this level is not something to ignore. It does not have to mean an acute problem, but with GH, big bodyweight and androgens it needs attention and regular checks.

What I would suggest, without coming to TRT:
-first step: stop or strongly reduce orals
-simplify the stack: less compounds, less changes
-keep hydration and electrolytes solid every day
-don’t train to the limit the day before bloodwork
-repeat kidney markers and BNP in a few weeks, in calmer condition

This does not look like a catastrophe, but it’s also not “everything perfect”. More like a warning that the body is close to its limit and it’s smart to lower the stress now, so you don’t pay for it later.

 

[M@NU]

Ok, quick analysis, what I would say about it:
Kidneys (creatinine, cystatin C, eGFR)
Creatinine can be higher because of muscle mass, hard training and a bit of dehydration, I agree.
But cystatin C is going up over time, and that matters more than one single result. Also eGFR around 56 does not look like just “noise”. It’s not a disaster yet, but it’s not a clean card either. Good idea with ultrasound. I would also add urine check (albumin/creatinine ratio) and repeat cystatin after a few days with no hard training and with good hydration.

Liver (ALT/GPT)
ALT around 180 is probably not only from back day or leg day. With Var + Anadrol this is a very typical picture. GGT is low, so it does not look like real demage, but the liver is getting hit. I would seriously consider dropping the orals, at least for some time.

Lipids
LDL and TG look fine, but HDL 12 is very low. Classic when you use orals and heavy androgen load. Good LDL does not “fix” that. If you cut something first, again, cut the orals.

Blood (Hb, HCT)
Hemoglobin and hematocrit are higher, but not crazy yet. Dehydration can push it too. Keep hydration on point and watch if HCT keeps going up.

Thyroid
TSH low, fT3/fT4 high-normal. Looks like mild “pharma hyper”, so lowering L-thyroxine dose makes sense. Your read here is ok.

ProBNP
If you have history of heart issues, BNP at this level is not something to ignore. It does not have to mean an acute problem, but with GH, big bodyweight and androgens it needs attention and regular checks.

What I would suggest, without coming to TRT:
-first step: stop or strongly reduce orals
-simplify the stack: less compounds, less changes
-keep hydration and electrolytes solid every day
-don’t train to the limit the day before bloodwork
-repeat kidney markers and BNP in a few weeks, in calmer condition

This does not look like a catastrophe, but it’s also not “everything perfect”. More like a warning that the body is close to its limit and it’s smart to lower the stress now, so you don’t pay for it later.

Hey @luki7788
really hoped you would chime in here because your a huge pillar of knowledge so thanks alot!!
i agree with everything you said. This is also the plan right now. Orals are already dropped since saturday and i also drop primo down to 175mg weekly and npp to 70mg (i need atleast this dosage for the joints)
I assume it would also get better without that because the long esters still clear but i know i am still blasting with 300/300/140, so time to trim it further down.
Will also include some Injectable Gluthation daily now to reduce stress on the liver.
Thyroid: i am currently taking 150µ T4 and 25µ T3. I will drop the T4 to 100 now

as you said, the kidney is the thing that wories me the most. But for the GFR: this is calculated based on the creatinine value. And since this is elevated, the GFR is reduced.
I assume my hydration status also played a role here and also for HCT/HB

i will follow your suggestions!

 

[Flex500]

Hey @luki7788
really hoped you would chime in here because your a huge pillar of knowledge so thanks alot!!
i agree with everything you said. This is also the plan right now. Orals are already dropped since saturday and i also drop primo down to 175mg weekly and npp to 70mg (i need atleast this dosage for the joints)
I assume it would also get better without that because the long esters still clear but i know i am still blasting with 300/300/140, so time to trim it further down.
Will also include some Injectable Gluthation daily now to reduce stress on the liver.
Thyroid: i am currently taking 150µ T4 and 25µ T3. I will drop the T4 to 100 now

as you said, the kidney is the thing that wories me the most. But for the GFR: this is calculated based on the creatinine value. And since this is elevated, the GFR is reduced.
I assume my hydration status also played a role here and also for HCT/HB

i will follow your suggestions!

just fyi there are eGFR calculators online that use both creatinine AND cystatin c and take into account bodyweight. You are right though, trend over time is the biggest thing to look at. If it was me personally I'd just drop to like 400 test and GH no orals and retest in 6-10 weeks or so. I'd also not train a good 3-4 days pre bloods.

 

[M@NU]

just fyi there are eGFR calculators online that use both creatinine AND cystatin c and take into account bodyweight. You are right though, trend over time is the biggest thing to look at. If it was me personally I'd just drop to like 400 test and GH no orals and retest in 6-10 weeks or so. I'd also not train a good 3-4 days pre bloods.

yes, im probably still too high.
i will prob try 300test 140primo (as e2 management) and drop npp completely + the orals.
maybe increase HGH to 15iu since i see no reason to drop the dosage since my HBA1C is fine and i dont hold lots of water on it)

i have an appointment on friday for urine and ultrasound of abdominal organs (self pay, thats why its so fast) but its worth the few euros for me to get some clearer result

and thanks for your input!!

 

[buck]

Interesting. My lab has the reference range of 0.61 - 0.95. Do they just make them up? This is from Bioscientia in Germany.

Every lab can have their own range for many/most blood tests. That is why where a person is in the range can be more important than the actual number.
They can use different machines, calibrate them different and even use different chemicals to analyze the sample. Causing a difference in results.
As i remember the difference between Quest and Labcorp for the top of the range of testosterone is about 200 points.
They throw out the top and bottom 2.5% and call the 95% in the middle "normal"

How to Understand Your Lab Results: MedlinePlus Medical Test

A lab test checks a sample of your blood, urine, or other body fluid or tissue to learn about your health. Learn more about how lab tests are used.

medlineplus.gov

 

[M@NU]

so i just had my talk with the doc and the ultrasound of the kidney:
the blood values do not concern her that much, those variances can be due to several factors and the values are still within the reference range or just above.
However, she did an ultrasound and saw that my kidneys are also enlarged (told me that kidneys are usually 10-11cm long, mine are between 13 and 14cm).
i googled a bit and found out that this is somewhat normal for enhanced athletes.
She gave me the option to see a nephrologist though and ive accepted it.. better safe than sorry..

 

[the_unit]

That pro-BNP level is concerning to me, I strongly encourage you get an echocardiogram as soon as possible.

 

[M@NU]

That pro-BNP level is concerning to me, I strongly encourage you get an echocardiogram as soon as possible.

hey buddy,
thanks for your worries, but this proBNP is the lowest since i took it first in 2020.
I have non-compaction cardiomyopathy and during 2020/21, i had three incidents where my EF was 15-20% before the cardiomyopathy was discovered.
back then my proBNP was 2000+. end of 2024 it was a bit over 600.

 

[the_unit]

hey buddy,
thanks for your worries, but this proBNP is the lowest since i took it first in 2020.
I have non-compaction cardiomyopathy and during 2020/21, i had three incidents where my EF was 15-20% before the cardiomyopathy was discovered.
back then my proBNP was 2000+. end of 2024 it was a bit over 600.

Well that perfectly explains its elevation ahaha