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Anabolic Research Update By William Llewellyn
Written by William Llewellyn
Saturday, 28 March 2009
Oral Equipoise?
Q: A guy I buy my gear from told me he would be selling oral Equipoise soon. Is this true? Is it even possible to take Equipoise orally?
A: Yes, indeed this rumor is true. My sources inside British Dragon have just confirmed for me that they’re working on this product, so expect to find this steroid with a BD “Boldabol” label on it very soon. I suspect a lot of readers are scratching their heads right now. Equipoise is an injectable steroid, not an oral, right? Well things aren’t always quite that simple with steroids. To give you a little chemistry background, most oral steroids are c-17alpha alkylated structures. This modification, also known as c-17a-methylaton, does an almost complete job of protecting a steroid from the destructive digestive process (mainly liver breakdown of the steroid). This allows it to reach the bloodstream intact, whereas unprotected steroids like testosterone and nandrolone are essentially useless via oral administration. Almost every oral steroid we’ve become familiar with is a “methylated” agent and for obvious good reason.
But when we look at boldenone, we don’t have c-17-methylation on this steroid (actually, methyated boldenone is Dianabol). So where does this leave us? Boldenone may not be methylated, but that doesn’t necessarily mean it’s useless when taken orally. Strong resistance to liver breakdown, as in c-17-methylation, also makes a steroid somewhat liver toxic and to minimize this a few less-toxic “exceptions” to the methylated-oral rule have been created. These include Proviron, Primobolan and Andriol. These steroids are few in number next to their methylated cousins and are also not very potent in comparison. But they work if you take a high enough dosage. It’s all about resistance to metabolism and it doesn’t matter how a steroid avoids liver metabolism, just that it does. In the case of boldenone, we have a steroid that’s inherently somewhat resistant to hepatic breakdown because of its 1,4-androstadiene base structure. Also known as dehydrotestosterone, boldenone can offer a “fair” level of oral bioavailability, probably in the same ballpark as Primobolan or Proviron. In this case BD has modified it with an acetate ester, a structure also found on Primobolan. This ester also helps protect the steroid, but not significantly (try using testosterone acetate orally and you’ll see what I mean).
In my opinion, consumers can look at oral boldenone sort of like oral Primobolan or oral trenbolone acetate. These steroids work if you take a high enough dosage, but also tend to be very cost ineffective compared to injecting the same agents. So in this case we’re trading total oral bioavailability and potency for a safer (less liver toxic) oral option. Or perhaps in the eyes of some consumers, they’re gaining access to a steroid normally off limits because it’s taken only by injection (hey, some people hate needles). Either way, you’ll see this steroid soon. I have my doubts whether it will set the market on fire, but not that it will work.
Written by William Llewellyn
Saturday, 28 March 2009
Oral Equipoise?
Q: A guy I buy my gear from told me he would be selling oral Equipoise soon. Is this true? Is it even possible to take Equipoise orally?
A: Yes, indeed this rumor is true. My sources inside British Dragon have just confirmed for me that they’re working on this product, so expect to find this steroid with a BD “Boldabol” label on it very soon. I suspect a lot of readers are scratching their heads right now. Equipoise is an injectable steroid, not an oral, right? Well things aren’t always quite that simple with steroids. To give you a little chemistry background, most oral steroids are c-17alpha alkylated structures. This modification, also known as c-17a-methylaton, does an almost complete job of protecting a steroid from the destructive digestive process (mainly liver breakdown of the steroid). This allows it to reach the bloodstream intact, whereas unprotected steroids like testosterone and nandrolone are essentially useless via oral administration. Almost every oral steroid we’ve become familiar with is a “methylated” agent and for obvious good reason.
But when we look at boldenone, we don’t have c-17-methylation on this steroid (actually, methyated boldenone is Dianabol). So where does this leave us? Boldenone may not be methylated, but that doesn’t necessarily mean it’s useless when taken orally. Strong resistance to liver breakdown, as in c-17-methylation, also makes a steroid somewhat liver toxic and to minimize this a few less-toxic “exceptions” to the methylated-oral rule have been created. These include Proviron, Primobolan and Andriol. These steroids are few in number next to their methylated cousins and are also not very potent in comparison. But they work if you take a high enough dosage. It’s all about resistance to metabolism and it doesn’t matter how a steroid avoids liver metabolism, just that it does. In the case of boldenone, we have a steroid that’s inherently somewhat resistant to hepatic breakdown because of its 1,4-androstadiene base structure. Also known as dehydrotestosterone, boldenone can offer a “fair” level of oral bioavailability, probably in the same ballpark as Primobolan or Proviron. In this case BD has modified it with an acetate ester, a structure also found on Primobolan. This ester also helps protect the steroid, but not significantly (try using testosterone acetate orally and you’ll see what I mean).
In my opinion, consumers can look at oral boldenone sort of like oral Primobolan or oral trenbolone acetate. These steroids work if you take a high enough dosage, but also tend to be very cost ineffective compared to injecting the same agents. So in this case we’re trading total oral bioavailability and potency for a safer (less liver toxic) oral option. Or perhaps in the eyes of some consumers, they’re gaining access to a steroid normally off limits because it’s taken only by injection (hey, some people hate needles). Either way, you’ll see this steroid soon. I have my doubts whether it will set the market on fire, but not that it will work.
