Parkinsons Disease

[Capin]

About three years ago after some tests and doctor visits I was diagnosed with Parkisons, Its gotten worse since then. Not wanting to go the traditional route for treatment I tried glutathione IVs, Humanofort and lately LDN (low dose naltrexon) with no success. The trembling in my left arm and leg is having a negative impact on what I love to do most weight training. I have to focus all my attention to those body parts while training. Its becoming quite anoying I get some strange looks when I hand someone a piece of paper with my left hand or reach for something and miss it I dont want anyone at my work to know but its getting hard to hide. I was hoping to slow the progression with the treatments I have tried but no luck. I am reluctant to go to a nerologist and start the standard drug therapy from what I have read and the people that I have talked to with this disease the side effects from the meds are pretty bad.

I was wondering if anyone else here is dealing with this?

 

[deerslayer41]

No brother i am not, but I wish you the best of luck.

 

[Hymlock]

I don't know if it's pre-parkinsons or not, but for the last 6 months I've had shaking of several fingers, and I don't have the grip I used to have. CoQ10 in the higher doses is supposed to help, but you may be to far along..
Good Luck!!!

 

[emeric delczeg]

About three years ago after some tests and doctor visits I was diagnosed with Parkisons, Its gotten worse since then. Not wanting to go the traditional route for treatment I tried glutathione IVs, Humanofort and lately LDN (low dose naltrexon) with no success. The trembling in my left arm and leg is having a negative impact on what I love to do most weight training. I have to focus all my attention to those body parts while training. Its becoming quite anoying I get some strange looks when I hand someone a piece of paper with my left hand or reach for something and miss it I dont want anyone at my work to know but its getting hard to hide. I was hoping to slow the progression with the treatments I have tried but no luck. I am reluctant to go to a nerologist and start the standard drug therapy from what I have read and the people that I have talked to with this disease the side effects from the meds are pretty bad.

I was wondering if anyone else here is dealing with this?

Check you email.

 

[Ghetto Gunfighter]

I'm not personally, but my dad has it. I'd love to find a way to help him, if you make headway please share it with us. I hope it goes well for you brother.

 

[fstr03svtcobra]

Hey brother I am really sorry to hear this! When you are talking about the typical parkinson's drugs are you talking about dopamine agonists like caber or prami?

 

[Capin]

Got ur email Emeric Ill call you sometime this weekend Thanks!

Ya Fstrcobra there are like five primary drugs two of which you mentioned the doses are pretty high for the disease.
I dont know why the past couple weeks my left index finger and thumb have been shaking so bad I can hardly use them?

 

[Capin]

Leevadopa is the most popular drug but it has many drawbacks nausea is one

Thinking about trying acupucture next

 

[Capin]

Correction Levodopa

 

[fstr03svtcobra]

Ya Fstrcobra there are like five primary drugs two of which you mentioned the doses are pretty high for the disease.

I got you brother. Don't know if you're religious, but I'll keep you in my prayers.

 

[LK3]

About three years ago after some tests and doctor visits I was diagnosed with Parkisons, Its gotten worse since then. Not wanting to go the traditional route for treatment I tried glutathione IVs, Humanofort and lately LDN (low dose naltrexon) with no success. The trembling in my left arm and leg is having a negative impact on what I love to do most weight training. I have to focus all my attention to those body parts while training. Its becoming quite anoying I get some strange looks when I hand someone a piece of paper with my left hand or reach for something and miss it I dont want anyone at my work to know but its getting hard to hide. I was hoping to slow the progression with the treatments I have tried but no luck. I am reluctant to go to a nerologist and start the standard drug therapy from what I have read and the people that I have talked to with this disease the side effects from the meds are pretty bad.

I was wondering if anyone else here is dealing with this?

interesting. I have seen videos on the glut IV's in elderly and seemed promising. the one thing tome that jumps out is that they are using big doses usually.

have you tried regular im admin of this compound say in the 600-1200mg wk range?

also the other antiox inject SOD as there is a relation between the two.

pterostilbene really jumps out as applicable here because of the nerve excition aspects, though resveratrol may be helpful too.

have you played with alc at all? again strong cns reaction.

try using agents that help the cns and practice the movements you have trouble with. I would think trying to create new nerve innerventions would be the way to slow the progress of this.

while its pretty different I had a friend with epilepsy phenobarbital helped her seizures and tremors a lot as did cannabis. the combination made her ok when her siezures got really bad.

 

[Hymlock]

Another post, I had to do a little research - marijuana is used with great success in treating Parkinsons symptoms.. Hope this helps..

 

[PyrofighterLA]

Thoughts and prayers with you buddy! Good Luck and I'm sorry I can't be more help.

 

[gabe walker]

ok, how about Thymosin b 4, I posted this in the peptide section awhile back.

Researcher Reports That RegeneRx's Thymosin Beta 4 Can Trigger Maturation Of Brain Stem Cells

Thymosin Beta 4stimulates oligodendrogenesis, the process by which central nervous system (CNS) progenitor cells (immature specialized brain cells) become oligodendrocytes that secrete myelin, the covering of nerve fibers. This process is important for the repair, regeneration and function of CNS tissue damaged by disease or trauma.

**broken link removed**

Lists all of regenerx's research


Parkinson's Disease: Non-Motor and Non-Dopaminergic Features
(Google Books)

IGF is neurotrophic... IGF > BDNF have major effect on promoting neurogenesis and synaptogenesis and neuro cell survival


IGF-1 May be a Biomarker for Early Parkinson’s Disease
IGF levels are increased in early Parkinson's possibly as a result of protective response then fall off as disease progresses..

Validation of IGF-1 as a Neuroprotective Agent in Pre-clinical Models of Parkinson’s Disease
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1035


Cerebrolysin is neurotrophic BDNF , GDNF, NGF,

Sildenafil (viagra) induces neurogenesis and oligodendrogenis and may reduce levodopa-induced dyskinesia in Parkinson's as well..

Sildenafil enhances neurogenesis and oligodendrogen... [PLoS One. 2012] - PubMed - NCBI

and of course curcumin has quite a lot of research behind it already...

Curcumin: a potential neuroprotective agent i... [Curr Pharm Des. 2012] - PubMed - NCBI

Melatonin with IGF/ Growth Hormone

Moriya, et.al. (2007) demonstrated that melatonin at pharmacologic doses exerts potent modulatory effect on the differentiation of neural stem cells during the proliferation phase and during the differentiation phase of the process, both increasing and decreasing neurogenesis respectively. Fernandez-Tresguerres Hernandez (2004) had presented data supporting these findings but added an additional interesting insight. There appears to be synergistic facilitation of neurogenesis by the combination of human growth hormone or IGF1 together with melatonin


Glutamate is neurotoxic
NMDA-R antagonists Memantine or much safer and possibly just as effective...NAC, glycine, Sarcosine
Sarcosine with NAC or glycine works synergistically

 

[gabe walker]

Damn couldn't edit in time...

Curcumin modulates dopamanergic receptor
Curcumin modulates dopaminergic receptor, CREB ... [J Biomed Sci. 2010] - PubMed - NCBI

Neurodegenerative shielding by curcumin
Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats

The MS drug Glatiramer acetate possible for Parkinsons

Glatiramer acetate could be a potential thera... [Med Hypotheses. 2007] - PubMed - NCBI

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate
Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate

Novel Anti-Inflammatory and Neuroprotective Agents for Parkinson's Disease
ingentaconnect Novel Anti-Inflammatory and Neuroprotective Agents for Parkinsons...

Hope any of this helps... My son has Aspergers so much of this overlaps with what I have been researching for him..

Also as to the NMDA-R antagonists.. more specific there are the mGluR5 antagonists MTEP and MPEP in development that are obtainable fro chem suppliers... I came across for my sons OCD and aspergers symptoms but found this as well...

Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys
Effect of the metabotropic glutamate recep... [Neuropharmacology. 2010] - PubMed - NCBI

and mGluR5 antagonists related to autism and results of several studies.
Autism-Like Behaviors Corrected in Mice - The Jackson Laboratory

There are a few more in development with several due for market in the next year or two, so I'm patiently waiting...

 

[saudades]

Cabergoline is also being used to treat Parkinsons in the early phase. I've been researching on this myself since I've also experienced tremors the same way for that past 3-4 years.

 

[gabe walker]

also low dose lithium as orotate.. very cheap OTC supplement.. I added it several weeks ago. one cap a day 5mg per cap

Doctor's Best Lithium Orotate -- 200 Tablets $11.59
lithium orotate - Vitacost

Lithium as Treatment for Parkinson's Disease
Lithium as Treatment for Parkinson's Disease

Lithium Profoundly Prevents Brain Damage Associated with Parkinson's Disease
**broken link removed**

Lithium tested as Parkinson's drug
Lithium tested as Parkinson's drug - UPI.com
"The possibility that lithium could be effective in Parkinson's disease patients at subclinical levels is exciting, because it would avoid many side effects associated at the higher dose range,"

Read more: Lithium tested as Parkinson's drug - UPI.com

Lithium - a new weapon in the fight against Parkinson's?
**broken link removed**
Lithium "profoundly prevents" brain damage due to Parkinson's disease, according to early-stage tests of the commonly-used medicine.

and for longevity
Low-dose lithium uptake promotes longevity in humans and metazoans
Low-dose lithium uptake promotes longevity in hum... [Eur J Nutr. 2011] - PubMed - NCBI

Fountain of Youth from the Tap? Environmental Lithium Uptake Promotes Longevity, Scientists Demonstrate
**broken link removed**

 

[Capin]

I have been looking at Thymosin b4
Thanks guys

Thanks Gabe!

 

[gabe walker]

I have been looking at Thymosin b4
Thanks guys

Thanks Gabe!

anytime

here's another one on curcumin... Study by the Michael J Fox Foundation

Exploring Curcumin and Curcumin Derivatives as putative Epigenetic target of Histone Deacetylase (HDAC) inhibition in Parkinson Disease
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=539

High Dose high Bioavailable Curcumin and low dose lithium orotate (5-10mg/day) are cheap to add... and Thymosin b4 sounds promising and readily available as is IGF... cycle them all together

 

[gabe walker]

oh and I forgot Mucuna Pruriens (velvet Bean) natural form of L-Dopa

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study.
Mucuna pruriens in Parkinson's... [J Neurol Neurosurg Psychiatry. 2004] - PubMed - NCBI

"The rapid onset of action and longer on time without concomitant increase in dyskinesias on mucuna seed powder formulation suggest that this natural source of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of PD. "

Faster onset of action and lower overall dose than Levodopa..

Mucuna Pruriens Shows Promise with Parkinson's Disease
Mucuna Pruriens Shows Promise with Parkinson's Disease