PED 34 with Mike Arnold

[thethinker48]

I didn't listen to the whole segment. The bits and pieces I did listen to, I'd suggest that Skip seeks out a sleep study too rule out sleep apnea. I would also have him check to see if he's a habitual mouth breather, durning wake periods and during sleep. This has a small yet an attribution to increased levels of deoxyhemoglobin. For lack of better terms, deoxyhemoglobin is nonfunctional deoxygenated hemoglobin. Different degrees of deoxyhemoglobin is also seen in those with uncontrolled sleep apnea and polycythemia. Deoxyhemoglobin increases cell mass volume, therefore will show an increase in serum hemoglobin or by a B-hemoglobin photometer. Something he may or may not be aware of, with a finger prick method (B-hemoglobin photometer) this can, on occasion show false highs, if: (a) the machine isn't calibrated correctly and (b) if the phlebotomist takes their jolly time transferring the collection slide to the machine. Normally for a healthy person it takes around 2 to 6 minutes for blood to clot. If we was to quantify the measure of time of a finger puncture to the photometer from minutes to prolonged seconds we would see a gradual increase in hemoglobin. A photometer works by emitting light through the test slide to determine our hemoglobin levels. If partial coagulation has occurred this process will lead to the formation of clots on the slide, reducing the lightwaves, therefore show a falsely elevated hemoglobin.

Something he can do to give him an indication if there is a possibility of degree of deoxyhemoglobin. He can prick his finger, try to pool as much blood as he can. If there's a dark blue hue to his blood, this is a good indication there's some sort of diease process or uncontrolled sleep apnea.

Something else he may consider also. If he has hypertension, that's not controlled by an Rx, he might consider speaking to his primary care provider about the use of an ACE inhibitor or an ARB (angiotensin receptor blockade). There's data indicating both of these HTN drug have been shown to have suppressive actions on erythropoietin. Ultimately, lowering red blood cell production. Somethings to consider.

With all that said, our hemoglobin levels fluctuates throughout the day. Morning being generally higher than afternoon or evening hours.

You guys were hitting on the topic of aspirin being a blood thinner. Aspirin isn't a blood thinner per se. Aspirin works by interfering with the synthesis of prostagandins which blocks the synthesis of thromboxane A2, therefore acts as an antiplatelet agent.

I've spoke my peace on isoenzymes. It's evident some people don't understand pharmacodynamics. So the general audience is aware, setting aside exmestane interactions with berberine. Several pharmaceutical drugs are metabolized by these isoenzymes; CYP2D6 and CYP3A4. Tread cautiously.

They need to get you on PED radio, would love to hear your input on some topics. If you don't mind me asking, Do you work as a coach, or in medicine?

 

[DECABEATZ]

Great informative episode!

 

[gotgame]

I didn't listen to the whole segment. The bits and pieces I did listen to, I'd suggest that Skip seeks out a sleep study too rule out sleep apnea. I would also have him check to see if he's a habitual mouth breather, durning wake periods and during sleep. This has a small yet an attribution to increased levels of deoxyhemoglobin. For lack of better terms, deoxyhemoglobin is nonfunctional deoxygenated hemoglobin. Different degrees of deoxyhemoglobin is also seen in those with uncontrolled sleep apnea and polycythemia. Deoxyhemoglobin increases cell mass volume, therefore will show an increase in serum hemoglobin or by a B-hemoglobin photometer. Something he may or may not be aware of, with a finger prick method (B-hemoglobin photometer) this can, on occasion show false highs, if: (a) the machine isn't calibrated correctly and (b) if the phlebotomist takes their jolly time transferring the collection slide to the machine. Normally for a healthy person it takes around 2 to 6 minutes for blood to clot. If we was to quantify the measure of time of a finger puncture to the photometer from minutes to prolonged seconds we would see a gradual increase in hemoglobin. A photometer works by emitting light through the test slide to determine our hemoglobin levels. If partial coagulation has occurred this process will lead to the formation of clots on the slide, reducing the lightwaves, therefore show a falsely elevated hemoglobin.

Something he can do to give him an indication if there is a possibility of degree of deoxyhemoglobin. He can prick his finger, try to pool as much blood as he can. If there's a dark blue hue to his blood, this is a good indication there's some sort of diease process or uncontrolled sleep apnea.

Something else he may consider also. If he has hypertension, that's not controlled by an Rx, he might consider speaking to his primary care provider about the use of an ACE inhibitor or an ARB (angiotensin receptor blockade). There's data indicating both of these HTN drug have been shown to have suppressive actions on erythropoietin. Ultimately, lowering red blood cell production. Somethings to consider.

With all that said, our hemoglobin levels fluctuates throughout the day. Morning being generally higher than afternoon or evening hours.

You guys were hitting on the topic of aspirin being a blood thinner. Aspirin isn't a blood thinner per se. Aspirin works by interfering with the synthesis of prostagandins which blocks the synthesis of thromboxane A2, therefore acts as an antiplatelet agent.

I've spoke my peace on isoenzymes. It's evident some people don't understand pharmacodynamics. So the general audience is aware, setting aside exmestane interactions with berberine. Several pharmaceutical drugs are metabolized by these isoenzymes; CYP2D6 and CYP3A4. Tread cautiously.

Completely agree. You know my thoughts on those especially as it pertains to AAS users.

I think someone mentioned reserpine ( i think thats what carditone is) for HTN.. hmm well i personally would never use that. Id stick with losartan rather then depleting my neurotransmitters. I mean it would work for HTN and it suppose its better then not having HTN but not worth the risk for many patients and no other real added benefits on the RAS that ace or arbs have.

I didnt listen to the podcast and this is the first im hearing of it. Stewie let us know when your on lol Maybe ill listen then.

 

[Stewie]

They need to get you on PED radio, would love to hear your input on some topics. If you don't mind me asking, Do you work as a coach, or in medicine?

I'll pass on the PED radio, mainly due to time constraints, work and family life. My posts here lately have been few and far between.

I've talked to members here and on a few other boards I'm on, by phone, texts or Facebook messages offering suggestions. Even then it's hard to respond in a timely respectful manner.

No, I'm not a coach. I'm finishing undergrad school, working towards being a P.A.

 

[Chode Logan]

Chode Logan,

The show is great. You all make it very cool. Mike was great too. I enjoyed the show very much.

Maybe in the future, Mike could talk more about cholesterol health. Many of us here are very health oriented. This could be a great topic to discuss. Just a thought. I am sure you guys have a lot of cool things coming up.

On another hand, you mentioned carditone was able to fix your blood pressure. How much carditone do you take if you don't mind and what was your BP before vs. now?

I started with 2 caps a day, then down to one. It went from 140-160/90-95 to 100-115/70-85. The range is depending on what I weigh and what im running. Used low dose cialis as well.

 

[Stewie]

Completely agree. You know my thoughts on those especially as it pertains to AAS users.

I think someone mentioned reserpine ( i think thats what carditone is) for HTN.. hmm well i personally would never use that. Id stick with losartan rather then depleting my neurotransmitters. I mean it would work for HTN and it suppose its better then not having HTN but not worth the risk for many patients and no other real added benefits on the RAS that ace or arbs have.

I didnt listen to the podcast and this is the first im hearing of it. Stewie let us know when your on lol Maybe ill listen then.

I would highly, highly considered it if you was on there. I would be doing more listening, than talking

 

[gotgame]

I would highly, highly considered it if you was on there. I would be doing more listening, than talking

haha nice try. Unfortunately in real life I dont discuss AAS too much outside of a close group. I openly discuss TRT and its benefits and joke around about AAS with other doctors but for professional reasons I dont openly discuss it. Even when I did consults with board members for health reasons we never discuss AAS even though its implied.

Its still too early in my career ( less then 10 yrs out) to become a voice for safe responsible usage. For personal reasons its too much to risk. Or maybe id use one of those voice changer things so I could sound like Arnold and use a fake name lol

Besides I rarely discuss my own past usage in public forums and im told I can be "very intense" and "matter of fact" so it comes across as condescending lol.. Im working on it. I am giving a talk next week to medical residents (grand rounds) on athletic cardiomyopathies. Lots of good stuff that we discussed recently on here.

 

[Chode Logan]

Both of you guys are awesome to learn from and I always pay attention to your posts.


I just want to clear the air that while PED is meant to be informative, it is equally aimed at being entertaining, so don't be surprised if you guys are both smarter than what you hear in the show from the usual 3 hosts [emoji14]




Sent from my SM-N900W8 using Tapatalk

 

[Kalatu_Pharma]

Both of you guys are awesome to learn from and I always pay attention to your posts.


I just want to clear the air that while PED is meant to be informative, it is equally aimed at being entertaining, so don't be surprised if you guys are both smarter than what you hear in the show from the usual 3 hosts [emoji14]

Sent from my SM-N900W8 using Tapatalk

Its equally entertaining as it informative...I have listened to every show and some many times over....Mike was actaully your first guest and I've listened to it several times...You 3 are always good for may laughs....Skip and S2H go at it sometimes...and I see how you instigate

And if people want to ask questions I think it's o ly right to join **broken link removed**

Taylor aka Chode is Senior Editor and does a fantastic job..

Your welcome Taylor, now get Non Stop Bodybuilding back up...You and AJ Sims call those shows like a couple of bosses...

 

[nothuman]

Both of you guys are awesome to learn from and I always pay attention to your posts.


I just want to clear the air that while PED is meant to be informative, it is equally aimed at being entertaining, so don't be surprised if you guys are both smarter than what you hear in the show from the usual 3 hosts [emoji14]




Sent from my SM-N900W8 using Tapatalk

Seriously, we are lucky to have these two guys post here, whether they do PED radio or not. I learned more from Stewie the other day about VAP cholesterol and other similar things than I ever have from any doctor or even google as it pertained to my specific health/bodybuilding lifestyle.

 

[nothuman]

Its equally entertaining as it informative...I have listened to every show and some many times over....Mike was actaully your first guest and I've listened to it several times...You 3 are always good for may laughs....Skip and S2H go at it sometimes...and I see how you instigate



And if people want to ask questions I think it's o ly right to join **broken link removed**



Taylor aka Chode is Senior Editor and does a fantastic job..



Your welcome Taylor, now get Non Stop Bodybuilding back up...You and AJ Sims call those shows like a couple of bosses...

I agree, their site deserves recognition. I feel guilty for not posting there much

 

[Kalatu_Pharma]

Seriously, we are lucky to have these two guys post here, whether they do PED radio or not. I learned more from Stewie the other day about VAP cholesterol and other similar things than I ever have from any doctor or even google as it pertained to my specific health/bodybuilding situation.

Ya know a P.A. can help yoh more so than some doctors... it too a really smart P.A. to get my dad's diabetes and a few other aliments he had...went through several M.D's and finally a PA working under a doctor at a local clinic had him in his best shape ever.... Very impressive I thought....