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PEG IGF, PEG IGF DES, PEG HGH! Why not???

Phattony

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Aug 3, 2013
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I'm wondering why none of our pioneering research companies here at professional muscle have pushed the boundaries of peptide science by offering PEGylated versions of our favorite research peptides (besides MGF)??? From my research PEGylating is a fairly simple and economic process which stabilizes peptides, improves bioavailability, prolongs active half lives, and can profoundly increase the overall effectiveness of many volatile compounds with short half lives! Imagine Peg IGF or better yet Peg IGF Des! WTF would des with a three day half life be like? fuckin amazing!!! Shit the medical community has even researched peg growth hormone which had a greatly extended half life and the only reason they discontinued research is because of a minute amount of local cell death at the injection site! I have injected shit that hurt for a week, left lumps and bruises, and surely killed more than a Few cells in the process. PEGylated peptides could revolutionize the research industry! Or not... Think about it sponsors... Just an idea from an average joe gym rat...
 

rradam

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Phattony

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557
I have also been wondering about this.
Especially pegylated GH..
Think about this... You guys that are useing gh at 5-10IUs e/d and doing multiple injections in an effort to keep you levels elevated. You could feasibly use a smaller dose once a day maybey even e/o/d and get the same effectiveness. Not only does PEGylating extend half life it protect the volitile amino acid chains structure therefore dilivering a more potent and pure hgh molecule. Not one that has been degrading since the day it was manufactured. I think degradation plays a larger role in the potency of many of our peps and hgh than is commonly believed.
 

Phattony

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This is from American Peptide Company:
PEGylation
American Peptide Company, Inc. makes the case for slightly increasing the cost-of-goods of peptide APIs by chemical modification with PEG as a cost-effective trade-off for a potential increase in bioavailability over the injected naked peptide.

PEGylation is an FDA-approved delivery system for peptide and protein-based biopharmaceuticals. The process of specific PEGyaltion involves the chemical attachment of polyethylene glycol (PEG) to a therapeutic peptide or protein at a specific site on the molecule. Your API can have significantly improved therapeutic properties, including better patient compliance and side effect profile.

The case for PEG conjugation (PDF - 544 KB)
-Improved Pharamacokinetic Increased circulation time
-enhances solubility
-decreases amount of API required
-improves stability
-decreases dosing frequency
-sustains absorption
-optimizes biodistribution
-sustains biopharmaceutical action
-reduces renal clearance
-Decreased toxicity
-improves safety profile
-reduces immunogenicity
-improves safety profile
-reduces proteolysis
 

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