Oral Peptide for leaky gut and general gut issues etc.
Just speculating but this stuff + KPV FTW for gut issues.
Just passing this along as I’d never heard of it and tons of people have gut dysbiosis
Google:
Larazotide (larazotide acetate) is an experimental, orally active peptide drug designed to tighten the gut barrier by blocking zonulin, which helps control intestinal permeability, originally studied as an add-on for celiac disease but discontinued for that use; it's now showing promise in studies for improving outcomes in
Post-COVID conditions (Long COVID) by reducing gastrointestinal symptoms and viral load in children
It works by acting as a
zonulin antagonist, preventing the "leaky gut" that allows inflammatory substances to pass through the intestinal lining, and is not yet FDA-approved for any condition
How it Works
Just speculating but this stuff + KPV FTW for gut issues.
Just passing this along as I’d never heard of it and tons of people have gut dysbiosis
Google:
Larazotide (larazotide acetate) is an experimental, orally active peptide drug designed to tighten the gut barrier by blocking zonulin, which helps control intestinal permeability, originally studied as an add-on for celiac disease but discontinued for that use; it's now showing promise in studies for improving outcomes in
Post-COVID conditions (Long COVID) by reducing gastrointestinal symptoms and viral load in children
It works by acting as a
zonulin antagonist, preventing the "leaky gut" that allows inflammatory substances to pass through the intestinal lining, and is not yet FDA-approved for any condition
How it Works
- Targets Tight Junctions: Larazotide blocks zonulin, a protein that can open up tight junctions (seals) between intestinal cells, making the gut more permeable.
- Restores Barrier Function: By preventing zonulin from acting, it helps keep these junctions closed, reducing "leaky gut" (intestinal permeability).
- Reduces Inflammation: This improved barrier function stops harmful substances, like gluten in celiac disease, from entering the bloodstream and triggering inflammation.
- Celiac Disease: Investigated as a treatment alongside a gluten-free diet, it showed promise in preventing gluten-induced symptoms and antibody increases but faced discontinuation in Phase 3 trials due to logistical challenges, not necessarily lack of efficacy, notesCeliac.org.
- Long COVID/MIS-C: Recent trials show it significantly speeds up recovery from gut issues, clears SARS-CoV-2, and helps children return to normal activities faster in severe post-COVID conditions (MIS-C).
- Other Conditions: Its ability to regulate tight junctions suggests potential for other permeability-related issues, with research exploring its role in arthritis and ischemic injury.
