Lutalyse/ProstaMate is prostaglandin f(2alpha) also known as PGF2a or dinoprost tromethamine, and is used to induce estrus and abortion in animals.
A few years ago I have access to the real stuff and used a few bottles myself.
I tried IM, SubQ, and even topical. No matter the dose I took, I never got explosive bowel movements or even anything close to it. It definitely does make you want to go pinch a loaf, but nothing remotely uncontrollable.
IM is the most painful, I used anywhere from 0.05ml (5 on a slin pin) to 0.5ml (50 on slin pin), and let me tell you putting .25ml into each calf is not a good idea is you plan to walk anywhere for an hour or so.
SubQ is less painful and seemed to work just as well, so after my first bottle I pretty much stuck with SubQ injections. I used an entire 30ml bottle on my calves and never say ANY local growth.
As for fat loss, I will agree that it does have a slight hardening effect. I definitely got harder and quite a bit more vascular when using it, both IM and SubQ. I never tried it topical for long enough to be able to say how effective it was.
In my opinion the pain is fairly mild. Dehabilitating at first, but mild. IM is worse, and it is a fairly dull pain in the muscle that subsides in about 10 - 20 minutes, but you can still feels it slightly for a few hours. SubQ was more of a burning type pain under the skin that made my want to rub it, which went away slightly quicker. Pain is definitely proportional to dosage.
Yes to the very temporary increase in body temperature and the effects on blood sugar. Both noticeable and also proportional to dosage. No matter how often or how much I took it, I never seemed to build any type of a tolerance to any of the effects.
I would definitely use it again, but in my opinion it is nowhere hear as effective as DNP, and it produced no localized growth for me. Also, injecting a large dose into your delts is a really bad idea.