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Very interesting article on how plant derived stress protectors and adaptogens have anticoagulant and nitric oxide boosting benefits in response to cortisol and other mechanisms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155223/
It would appear that repeated treatment with these drugs results in adaptation of the organism to the “stressors”. A single dose of rhodioloside or of an extract of S. chinensis or R. rosea decreased the thromboxane B2 level implying inhibition of platelet aggregation, blood clotting and an anti-stress effect.
Testosterone significantly increased after repeated administration of an extract of E. senticosus, an effect that is consistent with previous observations also indicating an anti-stress effect of this drug
The mild stress-protective activity of the ginseng saponins is believed to be mediated through the blocking of ACTH action in the adrenal gland (Kim et al. 2003a, b) and by inducing NO production in the brain (Kim et al. 1998). Administration of a single dose of P. ginseng increased working capacity in rats by up to 132% (Filaretov et al. 1988): interestingly, although the effect of repeated administration over a 7 day period was more pronounced (179%), it was not accompanied by further changes in blood cortisone level.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155223/
It would appear that repeated treatment with these drugs results in adaptation of the organism to the “stressors”. A single dose of rhodioloside or of an extract of S. chinensis or R. rosea decreased the thromboxane B2 level implying inhibition of platelet aggregation, blood clotting and an anti-stress effect.
Testosterone significantly increased after repeated administration of an extract of E. senticosus, an effect that is consistent with previous observations also indicating an anti-stress effect of this drug
The mild stress-protective activity of the ginseng saponins is believed to be mediated through the blocking of ACTH action in the adrenal gland (Kim et al. 2003a, b) and by inducing NO production in the brain (Kim et al. 1998). Administration of a single dose of P. ginseng increased working capacity in rats by up to 132% (Filaretov et al. 1988): interestingly, although the effect of repeated administration over a 7 day period was more pronounced (179%), it was not accompanied by further changes in blood cortisone level.
