Prami and Tagamet (Cimetidine)

[MegatronsMuscle]

I wanted to share an interesting experience I had with Prami. I have been on a low dose (.25mg) for a few days now. Besides the noted insomnia, nothing really big as far as sides are concerned.

On my carb re-feed day (cheat day) I had to take a couple of Tagamet pills (cimetidine) to help offset any heartburn that I might get due to my massive intake of food that day (taken about 2 hours before my Prami dosage). Big mistake. My .25mg of Prami all of a sudden felt like I took 2 mg. I could not stand up (or even sit up) without feeling extremely dizzy and very nauseous. I was up feeling like this all night along with cold sweats and the like.

I did some searching and found that Macro indicated that the half-life is increased by 40% and its measurable effect increases by 50% (if I am understanding what AUC means in pharmacology terms). Whoa.

Don't take your Prami with Tagamet!

 

[Macro]

good advice and it bears repeating... a lot of antacids and other OTC drugs can have significant effects on the script and gear that you take.

grapfruit juice decreases oral steroid and regular androgen metabolism (at least in the liver--- still expect to see metabolite formation.. more generally-- so that might be good or bad)

 

[Macro]

bump this up... acid reflux is not that uncommon