Prami...this shits insane!!!

[hardcoremt]

Alright its 652am im wide awake. Im NEVER up this early. Prami is some messed up shit!!
Ive NEVER dreamed this hard in my life. I remember my dreams vividly. Like really detailed memories. And i get up and pee like 5 times a night and fall right back into a dream. Yesterday i was an emotional wreck. Feel good so far today but after such awesome dreams how couldnt i be in a great mood.
If Gyno is gone and im not using nor's at the time how long should i continue Prami?

 

[klowndog]

Whats your dose and how long you been taking it?

I have been taking .25mg before bed for the last 2 weeks. No gyno probs. I have been emotional, but don't know if its from test/deca/prami, or because I've been having drama with the gf. Have had some vivid dreams also.

 

[musicmann89]

i know what u mean i just started at .25 the other night, i notice i wake up about 3 hrs after i fall sleep, than i go back to bed wake up around 6 and am wide awake, today i just started my second dose in the am when i get up so .25 in am and .25 at night

 

[hardcoremt]

No doubt!!
That shits Heavy Duty!
I take .5 mg before bed last night was my 5th night. I actually got mine from a parkinsons patient. Tabs of Miraplex 5mg each. Dude thinks im a weirdo wanting his Prami LOL.

 

[musicmann89]

No doubt!!
That shits Heavy Duty!
I take .5 mg before bed last night was my 5th night. I actually got mine from a parkinsons patient. Tabs of Miraplex 5mg each. Dude thinks im a weirdo wanting his Prami LOL.

i got the .25 mirapex tabs there tiny like a grain of rice

 

[hardcoremt]

i got the .25 mirapex tabs there tiny like a grain of rice

Hell mine look like a small oval tic tac. Not small

 

[Macro]

pramipexole is sold under the tradenames mirapex and sifrol among others, there are some generics.

as a note- there have been questions about the quality of indian generics (no word on chinese- though have not seen them), and serious problems with the quality of their cabergoline. (cabgolin brand in particular)-- in all honesty the cabergoline synthesis is beyond the capabilities of most manufacturers (and to be fair the indians are good at established synthesis, but there are only 3 companies making it with any quality 1 in china, 1 here and 1 in europe. here and europe are direct pfizer subsididaries. (there are some resellers in china but only 1 place making it and cant verify that quality either.)


if you are doing research you can get 1mg/ml solution of pramipexole from researchstop.com

 

[Macro]

gotta put this up again... cause its "insane"... in a good way

PubMed Central, : Br J Clin Pharmacol. 2007 November; 64(5): 591?602. Published online 2007 June 19. doi: 10.1111/j.1365-2125.2007.02938.x.

 

[Macro]

update(s)?

 

[John99Test]

This is the kind I have. Any good Macro?


**broken link removed**

 

[Macro]

indian made... questionable...but???... definitely would avoid their cabergoline. pramipexole is not as complicated but still its synthesis is not simple. as difficulty of synthesis increases the idea of using indian sourced tabs decreases exponentially.

 

[John99Test]

I mean the pramipexole is in blister form with directions and everything. Do you mean the problem is at the manufacturing level? I mean this is a lot of work to package if they are sending out bogus stuff.

 

[Macro]

I mean the pramipexole is in blister form with directions and everything. Do you mean the problem is at the manufacturing level? I mean this is a lot of work to package if they are sending out bogus stuff.

packaging is cheap. and it sells stuff. indian generic sildenafil was very questionable and inconsistent for a long time, but it was packaged real nice in nice copies of pfizer's packaging.

bogus is a strong word. was Brovel bogus, no. did their quality and consistency of dose suck. YES. was it underdosed, yes. was it overdosed, sometimes. was it loaded up with BA/BB sometimes, to the point of causing near abcesses. but brovel was "legitimate" holograms and all.

in the case of india and synthesizing complex molecules, few companies are up to the task of making cabergoline (maybe 5, 6 if you count the one semi-validated 1 chinese manufacturer). Not a tremendous number of shops can or do synthesize pramipexole, see where this is going. Indians are great when it comes to certain types of synthesis, particularly extractions (not like they are in the US, but they are low first tier when it comes to that). they are pretty decent at moderate level bulk synthesis and extractions. Cabergoline, seriously its beyond their ability to synthesize consistently, if at all. As mentioned uncertain with respect to pramipexole. Though an indian company (one) does have a license here in the US. Of course sun pharma, does not have such. while they list a lot of manufacturers almost all products are made by cipla and sunpharma. DO find it very shady that they list cabgolin by sunpharma, however sunpharma (not approved) makes caberlin. though cabgolin has gotten quite bad reviews. Whatever. the devil is in the details, not quite sure what these details these are saying. Best that can be said is... Dunno.

 

[Steve123]

Macro,
no knock against any sponser here but if it's that difficult to synthesize Prami, even for a pharma company, what are the prospects of a research chem co. acheiving any level of consistency? If I'm missing any key points here, please forgive the ignorance.
Thanks

 

[Macro]

Macro,
no knock against any sponser here but if it's that difficult to synthesize Prami, even for a pharma company, what are the prospects of a research chem co. acheiving any level of consistency? If I'm missing any key points here, please forgive the ignorance.
Thanks

research chem companies dont do synthesis. except in very rare instances. and since watched the RS's pramipexole sample run through the GC/MS, prospects are very good.

if it were just that the indians were tableting US, european or chinese material, that would be different. Know that there are at least a couple companies in china that can make it consistently and with extremely high purity. But its an indian company and not one that has approval for pramipexole anywhere else.

no research company should be selling cabergoline, because its just not stable in solution. Plus most of the raw material being sold is of low purity to begin with, or only partly reacted. An associate, trying to help RS get one of the stabilized crystalline forms had several firms (aussie and european) look at synthesizing just the basic type I crystal, none of them even wanted to touch it.

if you want to get cabergoline get cabaser, actually reccomend against the barr pharma made here in the US. its not up to SPEC IMHO, having tried it. after that have to say that am a bit leery of all the approved (tentative) generics. cabaser is not actually technically a generic, its just the unpatented version of dostinex.

 

[Macro]

updates? thoughts?

 

[hardcoremt]

Ill never use it again after dude on this board almost dying.

 

[Macro]

Ill never use it again after dude on this board almost dying.

no one "almost died" and seriously if you are not mature enough to use it, then dont. but making such conclusions without even understanding things, then you really should not be using steroids either. Certainly dont consider using GH or insulin, might want to avoid transfats too.(bit facetious with the last but.... in light of such sillyness).

its called hyperglycemia, and unless one is actually a diabetic, it will pass. totally avoidable, and if one is aware easily dealt with.. of course, if one does not create a situation where blunted insulin response will be of issue, one does not have to worry about.

increasing GH, taking anabolic steroids, eating high fat, DEHYDRATION (taking aas, eating high protein--pretty much everyone here is somewhat dehydrated unless they drink a lot of water AND get sufficient potassium) and high salt foods will all blunt insulin response. Sodium load in particular will inhibit insulin release. so couple that with the high fat, high transfat, high sodium meal that said individual ate prior, then see prami spiking GH then add a highly sweetened tea, worse if its HFCS based with added sucrose. that there is a recipe for severe acute hyperglycemia, which is what happened. now thats pretty unpleasant, certainly to be avoided and easily could have been, but its not almost dieing.


couple of general recccomendations, prami or not.

1 liter of water per 30-40lbs of body weight
2mg MINIMUM potassium for every MG sodium (4mg reccomended)
do cardio
avoid transfats
limit saturated fats and balance the ones you take with omega-3's

though thats JMHO....

 

[MegatronsMuscle]

I did have a Cimetedine interaction problem during my first dose, but I love Prami. At .25mg ED it completely takes care of all the bad stuff that 19-Nor's are known for. Deca dick, lactation, or any prolactin sides for that matter - not an issue. Even my blood pressure has not elevated with a healthy dose of Deca every week.

I feel the same way about Prami as I do about Aromasin - it takes the sides out of running these compounds (unless you are one of those bodybuilders that attributes bloat to actual LBM gains). You do have to be smart though (with Prami especially) and read the drug interactions as well as the "when to take and how to take" protocols. If you follow that you will not have incidents of "almost dying". People take so much precaution when using anabolics but yet they pop in their ancillaries like they are vitamins.

 

[kandaandm]

I didn't "almost die", but I thought I was dieing.

after upping from .5ml to 1ml....the 1st day I was extremely tired...It seemed like I was walking in my sleep and I became very absent minded.

The 2nd day I was still very tired but I thought that perhaps I wasn't sleeping well.

The 3rd day I was very tired and then I broke out into cold sweats...shakes... shortness of breath....extreme fatigue....I could barely move...I was at work and I stumbled my way to my office...where I called my fiance'......She called the paramedics because I could barely formulate words as I was begining to pass out. (It felt like I was dieing).

I'm still here though....I was hauled off by an ambulance from my office to the emergency room. Perhaps if I develop Parkinsons sometime in my life I'll take it again....Other then that...I'm staying away.

My protocol was very much like some other protocols I read on here from others and there issues were rather mild.

I suppose I'm just more sensitive to it then some others. Never the less, you don't know if your more sensitive to it then others until you take it and find out.

I'm not saying it doesn't help some people....It just personally was way beyond the risk/benefit ratio for me.