pulmicort- cortico steroid inhaler.

[bhumik]

I am supposed to take a puff of pulmicort once a day.. how will it effect muscle synthesis . will it have a negative effect?

 

[aesop]

I am supposed to take a puff of pulmicort once a day.. how will it effect muscle synthesis . will it have a negative effect?

really should affect it at all. The inhalers and nose sprays don't raises blood levels of corticosteroids enough to decrease protein synth

 

[natabolic]

From Drugs.com:

"Mechanism of Action: Glucocorticoids are naturally occurring hormones that prevent or suppress inflammation and immune responses when administered at pharmacological doses. In general, glucocorticoids inhibit the activity of a variety of cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators involved in allergic and nonallergic/irritant-mediated inflammation (e.g., histamine, eicosanoids, leukotrienes, and cytokines). At the molecular level, unbound glucocorticoids readily cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Subsequent to binding, transcription and, ultimately, protein synthesis are affected. The result can include inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, and suppression of humoral immune responses. The anti-inflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, collectively called lipocortins. Lipocortins, in turn, control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of the precursor molecule arachidonic acid. Some of the net effects include reduction in edema or scar tissue as well as a general suppression in immune response. The numerous adverse effects related to corticosteroid use usually depend on the dose administered and the duration of therapy."

Now, i dont believe that the affect of protein synthesis would be ALOT. Nothing anywhere near the amount to strongly hinder gains.

 

[bhumik]

Damn i took 5 puffs of htat over 3 days
.. i m gonna stop..

 

[natabolic]

Bro, if it was prescribed to you, i wouldnt stop using it. Like i said, the affect would be limited.. talk to your doctor about it.

 

[ghostdog128]

Relax, that shit isn't going to make you stop growing. Please, unless you're a professional competitor I wouldn't be worried about the .675 ounces you may not gain from taking a cortico inhaler that uses doses in the mcg's and that you need to breathe. Besides, you use an inhaler for a reason: to get a localized effect of the medication and limit systemic effects. Very little of the medication becomes systemic.

Jesus, last time I checked breathing took precedence over gaining muscle.

I've been asthmatic for 20 years and these inhalers have never affected me.

 

[natabolic]

Relax, that shit isn't going to make you stop growing. Please, unless you're a professional competitor I wouldn't be worried about the .675 ounces you may not gain from taking a cortico inhaler that uses doses in the mcg's and that you need to breathe.

Jesus, last time I checked breathing took precedence over gaining muscle.

I've been asthmatic for 20 years and these inhalers have never affected me.

Bro, even if he was a pro, he shouldnt be worried about not gaining that extra pound or two in his WHOLE life. haha.

 

[ghostdog128]

Bro, even if he was a pro, he shouldnt be worried about not gaining that extra pound or two in his WHOLE life. haha.

Yeah, I know but pro's are the only ones that should really care about every ounce. And even then you're right, breathing/staying alive? or half a pound of muscle over 10 years? that's a tough one.. LOL

 

[natabolic]

Yeah, I know but pro's are the only ones that should really care about every ounce. And even then you're right, breathing/staying alive? or half a pound of muscle over 10 years? that's a tough one.. LOL

Damn, That would be a rather difficult decision. LOL