Quick metformin question

[chainheart]

...hey some of you have have read the same thread information before. if anyone is interested certificates are available for threads one thru seven and allows members to skip forward to the more advanced links that go through metformin thread number 32. you can send $7 with name you want printed and include your address for one certificate as seen below. please don't email me after 2 days asking if i received your request this ain't walmart. i'll include some freebie metformin information facts as long they last and please give me a response back on the quality of these metformin certificates. no C.O.D. requests please. some of you new guys better not mess this up.
Post not intended to diagnose or treat health issues

Certificates are not actually for sale and only intended to help point to need for more pm search engine use on topic answers before new threads are initiated.

 

[NY Muscle]

Can anyone recommend a good GDA to take that's OTC to compliment the metformin through your the day.

Berberine.

Sent from my SM-N900V using Tapatalk 2

 

[asteelz]

https://www.pharmgkb.org/pathway/PA165948566

Complete dynamics of metformin, this is also available on the elviser journal of clinical endocrinology and metabolism , but that one requires a membership to see the full journal and I am not sharing my membership info lol.

Primary actions mediates through phosphorylation of ampk.

 

[asteelz]

https://pubchem.ncbi.nlm.nih.gov/compound/metformin#section=Metabolism-Metabolites

Information on clearance times , absorption, and a reiteration of mechanism of action is available here as well for free

 

[Thebigone]

https://pubchem.ncbi.nlm.nih.gov/compound/metformin#section=Metabolism-Metabolites

Information on clearance times , absorption, and a reiteration of mechanism of action is available here as well for free

Can't open link on my darn phone. Can someone post what the clearance times and absorption are? Thanks in advance!

 

[asteelz]

Absorbed over 6 hours, bioavailability is 50 to 60% under fasting conditions. Administration with food decreases and delays absorption. Some evidence indicates that the level of absorption is not dose-related, suggesting that absorption occurs through a saturable process. Limited data from animal and human cell cultures indicate that absorption occurs through a passive, non-saturable process, possibly involving a paracellular route. Peak action occurs 3 hours after oral administration.
from DrugBank
Route of Elimination

Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion. Approximately 90% of the drug is eliminated in 24 hours in those with healthy renal function. Renal clearance of metformin is approximately 3.5 times that of creatinine clearance, indicating the tubular secretion is the primary mode of metformin elimination.
from DrugBank
Volume of Distribution

654 L for metformin 850 mg administered as a single dose. The volume of distribution following IV administration is 63-276 L, likely due to less binding in the GI tract and/or different methods used to determine volume of distribution.
from DrugBank
Clearance

718-1552 mL/minute following single oral dose of 0.5-1.5 g. Metformin is removed by hemodialysis at a rate of approximately 170 ml/min under good hemodynamic conditions.

 

[suppdude]

Can't open link on my darn phone. Can someone post what the clearance times and absorption are? Thanks in advance!

Absorbed over 6 hours with peak action occurring 3 hours post oral administration.

90% elimination of Metformin post 24 hours with health renal function.

Clearance being 718-1552 mL/minute following single oral dose of 0.5-1.5 g

Half-life is 6.2 hours with duration of action being 8-12 hours.

 

[Thebigone]

Absorbed over 6 hours with peak action occurring 3 hours post oral administration.

90% elimination of Metformin post 24 hours with health renal function.

Clearance being 718-1552 mL/minute following single oral dose of 0.5-1.5 g

Half-life is 6.2 hours with duration of action being 8-12 hours.

That's cool so even if you take say 500mg at 7am by 1pm you still have 250mg in you for another 6hrs.

 

[suppdude]

That's cool so even if you take say 500mg at 7am by 1pm you still have 250mg in you for another 6hrs.

Correct.