Receptor downregulation?

[DOOGIE DOG]

Do different steroids attach to different receptors? It's been said that all steroids primarily attach to and activate the same receptor. If that be the case then stacking several steroids would only be beneficial because a higher total steroid dosage would be obtained, not because of receptor downregulation or becoming insensitive to certain drugs. Correct? And if that be the case then 2 grams of test cypionate per week could be just as effective as a stack taking 1 gram of test -weekly, 400 mgs of deca weekly and 25 mgs of d-bol-daily.

On the other hand, some say drugs like deca hit different receptor sites than drugs like test and d-bol. If that be the case, then no amount of test and d-bol will provide the same results as test and deca once enough test was used to provide maximum stimulation to the receptors. I realize that an advantage of stacking is to provide higher blood concentrations of hormones while possibly experiencing less side effects but is stacking more effective if all steroids hit the same receptor?

SOMEONE PLEASE HELP EXPLAIN THIS!

 

[Dog-Slime]

I dont know about if different roids hit different receptors but some steroids have a lot of non receptor mediated benefits. Not real sure which ones do this but know I have read it before. So certainly a stack can be beneficial.

 

[DOOGIE DOG]

BUMP FOR MORE ANSWERS..

 

[Thewhite9t]

Well as far as I know, all androgenic steroids bind to the AR. Now I'm not sure that they all elicit the same effects when they bind to the AR. I know that some bind a lot tighter to the AR...ect.

Anabolic steroids on the other hand trigger growth by non-AR mediated mechanisms. Dianabol and anadrol come to mind in this catagory, but there are others.

There are anabolic/androgenic ratings for each steroid that will tell you which catagory that each falls into. But these ratings don't really have much bearing on how much growth the steroids will elicit.

Bottom line: They all cause growth in unique ways because anyone will tell you that you can't equate mg of one steroid to mg of another. For instance, 400mg tren + 400mg EQ do not equal 800mg of test, or really any mg of test, because the response in the body seems to be completely different.

Sorry if that's confusing. I'm sure some more knowledgable guys can put it in a much more clear manner.