Receptor Saturation???

[TheeBC]

I've been on cycle for almost 11 weeks now. I've been using Prop/Tren/Var in 100mg/75mg/100mg doses ED. I began hating the shoulder injects and became very comfortable with quads and glutes. So i was rotating those 4 ED

However, I noticed the past 2 weeks, my lifts weren't rising, my aggression seemed not to high anymore...etc I even feel like I put on a little weight on my mid section.


So, yesterday I decide to pin 2ml in the old shoulder, and immediately, I feel PUMPED! and I was short fused as hell...Im not a placebo guy, I really noticed my head change and attitude...

I cannot find much on the topic of Receptor Saturation through Google, was wondering if anyone could chime in?

My diet has been a shitty too. The prami has caused me a lot of insomnia and bad eating habits, along with low water intake. I also feel like my liquid var isn't working.
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[PsyT]

yo! i'm only on my second cycle so I can't speak from tons of experience...but damn man I have found this same exact thing to be true! When I hit a new injection spot (besides pain from virgin muscles being injected ) the stuff seems to absorb much quicker and more efficiently. When I hit a new spot in the morning and then work out a few hours later I am almost always at the top of my game feeling very strong and aggressive with the weights. I love it...I honestly thought it was in my head though!

I'll wait and see what others have to say...maybe we're just crazy bro!!!

 

[Macro]

the difference is in the local esterases, these vary between sites. pharmacokinetics are different between different sites and between differing volumes.

for more information and a more thorough explanation (mind you, not entirely in agreement with the study- however the general premises are fairly accurate)

check out
**broken link removed** (lots of good studies in full)

part of **broken link removed**

direct link to the relevant study

http://www.afboard.com/library/minto.pdf

 

[kevin3987]

11 weeks will not saturate your receptors!!!!!!!!!!!!!

 

[lazer05]

Its not the receptors per say, more an issue with a buildup of oil and maybe a very small amount of scar tissue. Going to a fresh area will (and did as you have already explained) allow it to move into the blood stream faster. You may feel tissue is a little harder or lumpy where you were injecting a lot too. Sometimes you'll feel a lump from the oil for many days after injecting a fast oil/ester that sould have been completely out of the area with a day or 2 but clearly is still pooling there. Switch up as much as possible, but 11 weeks of everyday is going to be hard no matter what. Need to hit tris etc maybe to give other areas rest.

Even medically they ALWAYS inject in 2 different areas if you get two shots at once even with small 1cc shots due to absorption issues with multiple shots. Rotate as much as you can bro. Good luck

 

[FoodFreak]

Receptor saturation is something that you will experience over longer periods of time depending on your cycle preferences. It is great to go off or on HRT for periods of 2 months minimum in order to maximize your response to your next cycle of higher doses. It is also great to change up the compounds throughout your cycle.The body likes homeostasis...it will adjust to whatever your doing which in the case of higher doses of anabolics- it down-reguates AR's...gotta keep tricking it up! just like with diet, training etc