Red marks and lumps at injection sites.

[LOCUST]

Hi, ive been using the cjc/ghrp 6 mix for about a month, in the last few days i have developed welts/lumps at the injection sites,

ive been doing sub q, there quite itchy and a little sore, any idears why im getting this ?

thanks

L

 

[Thick1]

Good question as I have experimented with CJC1295 and had the same thing happen red welts, itchiness and lumps. I reconstituted with BW and sterilized the injection site as well as used clean slin pins.

Anyone with any idea what is going on?

 

[chriswhat]

I have the exact same problem UNLESS I use 1/2 inch pins. Then I have no problem.

 

[Thick1]

I always use 1/2" pins and at the beginning I did not have these welts and itchiness only at the end of my cycle and the lumps stayed for a while.

 

[Chaos76]

I have been having the same problem at first nothing and now red marks!
it is the same vial, does anyone else have this problem?

 

[123cctv]

Hi, ive been using the cjc/ghrp 6 mix for about a month, in the last few days i have developed welts/lumps at the injection sites,

ive been doing sub q, there quite itchy and a little sore, any idears why im getting this ?

This type of reaction is extremely common with those particular peptides. In a nut shell, though the peptides are legit, there's something in them that the body doesn't agree with and thus, you experience an "immune system reaction" to which your body is attacking what it believes to be a foreign invader.

 

[DatBtrue]

I was asked about this on my board and here is what I said:

Sometimes it happens. Your body is reacting to a foreign substance. It doesn't last and is not harmful. For me it usually manifests itself as a light colored red/pink blotch that goes away within 10 minutes. About 3 percent of the time it can feel lumpish and about 1% of the time I can get a redness and itchiness with the redness lasting an hour. The later reaction I suppose is related to histamine.

I have histamine irritating my skin at the moment from provigil use (discontinued a month ago). I have to take an anti-histamine every day (Zyrtec (Cetrizine) ) to cope with itchiness. I believe that the reaction is also related to the anabolic/androgens [SEE Note I & II] as well as possibly propylene glycol.

Propylene glycol is an ingredient in Minoxidil that burns my scalp to the point where I can not tolerate commercial products. With the anti-histamine I can use commercial Minoxidil and solvents in injectables w/o irritation. This also means that I never have a site reaction to reconstituted peptides at the moment.

When I discontinue the anti-histamine I assume I will have an occasional reaction.

Now clinical grade is so much better that I rarely get welts. Few do. So if you are getting frequent welts then it may be a reaction to the BA in the BW or your technique or the place you are injecting is sensitive. Rotate sites and see what will happen. Use a sterile water (w/o BA) and see what happens.

Also how much BW are you using? Try to reconstitute the vial w/ less water say .4ml and see what happens.

NOTES:

NOTE I

Fixed drug eruption

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Medications can cause many skin reactions. This particular appearance is called a "fixed drug eruption" and was caused by a reaction to ceftazidime. This type of reaction typically recurs in exactly the same location when the person takes the same medication again.


True drug allergies occur when there is an allergic reaction to a medication. This is caused by hypersensitivity of the immune system, leading to an incorrect response against a substance that is harmless in most people. The body becomes sensitized (the immune system is triggered) by the first exposure to the medication. The second or subsequent exposure causes an immune response, including the production of antibodies and release of histamine.

Most drug allergies cause minor skin rashes and hives. However, other symptoms occasionally develop and life-threatening acute allergic reaction involving the whole body (anaphylaxis) can occur. Serum sickness is a delayed type of drug allergy that occurs a week or more after exposure to a medication or vaccine.

Penicillin and related antibiotics are the most common cause of drug allergies. Other common allergy-causing drugs include sulfa drugs, anticonvulsants, insulin preparations (particularly animal sources of insulin), local anesthetics such as Novocain, and iodine (found in many x-ray contrast dyes).

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NOTE II

Sex Steroids & Androgens can effect Histamine release​

Androgens have been shown to stimulate mast cells and thus may increase histamine response


First sex steroids under normal conditions:

Effects of castration and testosterone replacement on peritoneal histamine concentration and lung histamine concentration in pubertal male rats, A P Lima, L O Lunardi, Journal of Endocrinology (2000) 167, 71–75


Mast cells are the main source of histamine...

A growing body of evidence suggests that mast cells are regulated by the neuroimmunendocrine system. Many authors have reported that mast cells are significantly affected by sex steroids. In general, it seems that estrogens and androgens exert opposite effects on mast cells in rodents: while estrogens appear to stimulate cell proliferation, most studies indicate that testosterone is an inhibitory factor of cell proliferation.​

However the following study that was presented at a 1979 Proceedings Of The Nutrition Society reveals that high dose testosterone and both lower dose and higher dose trenbolone increase Histamine. Trenbolone increases polyamines which cross communicates with histamine.

Polyamine Excretion By Trenbolone Acetate Treated Rats, J. T. Pearson And P. J. Buttery, Proceedings Of The Nutrition Society Abstracts Of Communications Vol. 38 Meeting Of 8 May 1979


Trenbolone acetate is a valuable commercial anabolic agent.

Thirty female specific pathogen-free rats of the Wistar strain were housed in individual metabolism crates with continuous access to both food and water. They were injected daily for 14 d subcutaneously via the neck skinfold with either 100 or 1000 pg of testosterone or trenbolone acetate (TBA) dissolved in 0.1 ml corn oil/100 g body-weight. Control rats were injected with corn oil alone. During days 11-14 of the trial, 24 h urine samples were collected over acid (to minimize bacterial contamination) and pooled.

The urine was prepared according to the method of Henningson et al. (1976). Chromatographic separation was carried out at 58O on a 130x10 mm column of Aminex As resin (Bio-Rad Laboratories, Bromley, Kent), eluted with sodium citrate buffers, pH 6.16, IM (with respect to Na+ 0-70 min, pH 4.68, 2.4M, 70-250 min, pH 4.68, 3.05M , 250-430 min, flow-rate 0.5 ml/min. Peaks co- chromatographing with standards of histamine, putrescine, cadaverine, and spermidine were detected in the urine of both treated and untreated rats (Table).

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These increases in cadaverine and spermidine excretion following TBA treatment are consistent with the observed changes in the muscle intracellular concentrations of lysine and arginine (Vernon_ & Buttery, 1978). Polyamines are intimately involved with RNA metabolism (Cohen, 1971) and indeed TBA has been shown to affect muscle RNA concentration (Vernon b Buttery, 1978).

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