- Joined
- Jan 19, 2009
- Messages
- 1,839
16th century physician/alcheimist Paracelsus famously said “the dose determines the poison”
This is something that’s been on my mind for a while now.. We live in a society ( bodybuilders) where the limits are blurred and boundaries stretched. Everyone’s always talking about gram totals as a measure for the toxicity or intensity of a cycle of AAS. I do agree that this is relevant but only when taken into the appropriate context of compounds used.
For example. Person A, B, and C are all capped at “2g” per week..
Person A is taking 1000mg primo E, 400mg test c, and 600mg EQ.
Person B is taking 1000mg test P, 500mg tren A, and 500 mg winstrol oral
Person C is taking 700mg test suspension, 300mg superdrol oral, 300mg halotestin, and 700mg tren ace.
Each are totaling 2g, but they are drastically different in regards to toxicity potential and the ability to change a physique with all other variables aligned.
Granted the disparity in toxic load will become less apparent with doses above the 3-4 g range, as most if not all androgens both singularly or combined in those quantities will become acutely and chronically toxic.
Let us compound on the toxic potential of said individuals, A, B, C. assuming genetics are equal, middle of the road for each.
Person A is not likely to need a compilation of ancillary drugs to combat his usage. Perhaps some hypertension mitigation, lets say Lisinopril 10mg, or Micardis 40mg. The toxic load of either is minimal, with no added hepatotoxicity and possibly some nephro-protection in the Lisinopril
Person B will likely need some sort of estrogen mitigation, be it AI or SARM, perhaps Prolactin control via a dopamine agonist. Blood pressure is also likely to become an issue, as trenbolone seems to universally elevate this. With the addition of an oral and tren acid reflux is common, so lets also include a PPI, or proton pump inhibitor. Now were looking at , theoretically, 20mg+ of Lisinopril, or 40-80mg Micardis, An AI .5 adex ed or 12.5 aromasin ED, and esomeprazole 40mg daily. The deleterious effects on lipids and b12 now must be considered
Person C is at the greatest risk for toxicity, due to the use of strong orals and the highest doses of trenbolone. Blood pressure, lipids, GI health, Estrogen, prolactin, Sleep quality, and renal health all become an issue with his usage.
This is all before we begin to factor in the variables related to diet, rest, supplementation, peptide use including gh and insulin, OTC medications, and work variables.
Some points to consider for my brothers and sisters here on PM.. While total dose is important, it’s perhaps more appropriate to look at the dose range for each compound that contributes to said total when trying to be health conscious. Love you all and wish for everyone to stay healthy in their personal journeys in this insane sport.
This is something that’s been on my mind for a while now.. We live in a society ( bodybuilders) where the limits are blurred and boundaries stretched. Everyone’s always talking about gram totals as a measure for the toxicity or intensity of a cycle of AAS. I do agree that this is relevant but only when taken into the appropriate context of compounds used.
For example. Person A, B, and C are all capped at “2g” per week..
Person A is taking 1000mg primo E, 400mg test c, and 600mg EQ.
Person B is taking 1000mg test P, 500mg tren A, and 500 mg winstrol oral
Person C is taking 700mg test suspension, 300mg superdrol oral, 300mg halotestin, and 700mg tren ace.
Each are totaling 2g, but they are drastically different in regards to toxicity potential and the ability to change a physique with all other variables aligned.
Granted the disparity in toxic load will become less apparent with doses above the 3-4 g range, as most if not all androgens both singularly or combined in those quantities will become acutely and chronically toxic.
Let us compound on the toxic potential of said individuals, A, B, C. assuming genetics are equal, middle of the road for each.
Person A is not likely to need a compilation of ancillary drugs to combat his usage. Perhaps some hypertension mitigation, lets say Lisinopril 10mg, or Micardis 40mg. The toxic load of either is minimal, with no added hepatotoxicity and possibly some nephro-protection in the Lisinopril
Person B will likely need some sort of estrogen mitigation, be it AI or SARM, perhaps Prolactin control via a dopamine agonist. Blood pressure is also likely to become an issue, as trenbolone seems to universally elevate this. With the addition of an oral and tren acid reflux is common, so lets also include a PPI, or proton pump inhibitor. Now were looking at , theoretically, 20mg+ of Lisinopril, or 40-80mg Micardis, An AI .5 adex ed or 12.5 aromasin ED, and esomeprazole 40mg daily. The deleterious effects on lipids and b12 now must be considered
Person C is at the greatest risk for toxicity, due to the use of strong orals and the highest doses of trenbolone. Blood pressure, lipids, GI health, Estrogen, prolactin, Sleep quality, and renal health all become an issue with his usage.
This is all before we begin to factor in the variables related to diet, rest, supplementation, peptide use including gh and insulin, OTC medications, and work variables.
Some points to consider for my brothers and sisters here on PM.. While total dose is important, it’s perhaps more appropriate to look at the dose range for each compound that contributes to said total when trying to be health conscious. Love you all and wish for everyone to stay healthy in their personal journeys in this insane sport.