restoring Hormones to youthful levels lowers cholesterol levels

[MR. BMJ]

Thanks to Jboldman at CEM.


Neuro Endocrinol Lett. 2011 Feb 15;32(1). [Epub ahead of print]

Correction of steroidopenia as a new method of hypercholesterolemia treatment.

[No authors listed]
Abstract

OBJECTIVE: In 2002 we proposed a new hypothesis of the etiology and pathogenesis of hypercholesterolemia. There is paucity of information in the literature regarding the association of steroidopenia and hypercholesterolemia. Our goal is to determine if the treatment of steroidopenia with hormonorestorative therapy (HT) to youthful levels will normalize total cholesterol (TC) levels.

MATERIAL AND METHODS: We retrospectively analyzed 43 hypercholesterolemic patients treated with HT. Laboratory workup included lipid profile, serum pregnenolone, dehydroepiandrosterone sulfate (DHEA-S), progesterone, total estrogen, cortisol, total testosterone, and vitamin D-3 levels at presentation with follow up ranging from 3 to 9 months. HT therapy included a combination of several agents such as pregnenolone, dehydroepiandrosterone (DHEA), triestrogen, progesterone, testosterone, hydrocortisone, and vitamin D-3.

RESULTS: HT lowered mean TC from 228.8 mg/dL to 183.7 mg/dL (19.7%) (p<0.05) in all patients. In 12 men of mean age 58, HT statistically significantly lowered TC from 227.9 mg/dL to 177.1 mg/dL (22.3%) (p<0.05). Apparently it did so mostly by lowering LDL and triglycerides (TRG) while HDL did not appreciably change. In 31women, mean age 57, TC declined from 229.2 mg/dL to 186.3 mg/dL (19%) (p<0.05). HDL, LDL, and TRG are also decreased to a statistically significant degree. These results were associated with statistically significant elevations in pregnenolone, DHEA Sulfate, testosterone, progesterone but not total estrogen, cortisol or vitamin D-3 changes in both men and women.

CONCLUSIONS: We conclude that correction of steroidopenia with the use of hormonorestorative therapy is an effective strategy for normalizing and maintaining cholesterol homeostasis.

 

[BODYUNDRCONSTRUCTION]

Lowering HDL

This will be fine for someone that has the HDL levels normal or close to normal.Mine was at 9 and now it is at 13.I am taking 40mg simvastatin in the morning and 1000mg niaspan at bed time and i dont see this medications working really good.They been like this for like 6months.So what do we do next?Stop the gear?>>>>noooo.Come on fellaz there has to be something else.Some of the pros take way more than some of us with the same problem and they stay on for ever and how in heavens they do it to control their levels of cholesterol?