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Retatrutide

Seems to be the case based on the post you posted earlier. I'm not aware of any studies breaking down reduction in inflammation by dosage (if they even exist), but my thinking is that it's probably still very useful to run a low dose Tirz (2.5mg) on a gaining phase if blood sugar control is an issue; minimal interference but still significant effect on BG.
lol I have posted so many studies in this thread that I don’t even remember the one you’re talking about anymore. I’ll try to dig it up
 
I wonder... if after a high dose period of Tirz OR Reta that brings you down to a targeted bodyfat % if you can continue to use a low dose (say 1mg) year round to sustain that level AND for the anti-inflammatory/glucose control benefits? Is there ever a need to come off? Or is it like TRT, you simply use a low dose year round?
That’s exactly what I am doing. I’m just using a low dose for health benefits. I don’t plan to come off.

In fact, I think the obese people who lost tons of weight on it are silly for coming off. They clearly had issues controlling appetite so to put themselves back in a state of hunger again is illogical.
 
I wonder... if after a high dose period of Tirz OR Reta that brings you down to a targeted bodyfat % if you can continue to use a low dose (say 1mg) year round to sustain that level AND for the anti-inflammatory/glucose control benefits? Is there ever a need to come off? Or is it like TRT, you simply use a low dose year round?
I mean you’re allowed to use anything you want year round as long as you accept the known risk
 
I mean you’re allowed to use anything you want year round as long as you accept the known risk
OK that is obvious. Let me be more clear... what is the "known risk" of using reta or tirz year round at a low dose of say 1mg per week?
 
I was thinking the same... go with a slowly increasing dose until dropping weight consistently... then "pyramid" back down to a maint dose around 1/2mg twice a week for several more months to indefinitely ... sort of add it to the blast/cruise mentality we do with all other things lol
Leave it to us meatheads to find something used for one thing (weight loss and diabetes) and turn it into a physique enhancer lol. Bodybuilders always find that wormhole :)
 
OK that is obvious. Let me be more clear... what is the "known risk" of using reta or tirz year round at a low dose of say 1mg per week?
I think it’s too early to say if it’s a known risk or not but I’d be concerned with the elevated heart rate if you’re sensitive to it. I know some guys only get a few beats uptick and for some it settles down again, where others will get a 10-15 or even more uptick and it sticks. On top of the gear and GH and it would give me pause but like I said, if you’re one of the ones that it doesn’t effect so much then I wouldn’t worry about it.
 
I think it’s too early to say if it’s a known risk or not but I’d be concerned with the elevated heart rate if you’re sensitive to it. I know some guys only get a few beats uptick and for some it settles down again, where others will get a 10-15 or even more uptick and it sticks. On top of the gear and GH and it would give me pause but like I said, if you’re one of the ones that it doesn’t effect so much then I wouldn’t worry about it.
I think initially it ticked up a bit, but now its back down into the 60s with no issues. I have had no sides at all (other than the initial nausea from TZ). That went away after a few weeks. When I switched to Reta I had no sides, but the hunger did come back. So I still stand by my belief that TZ is better for cutting fat FAST whereas Reta is prob better for most bodybuilders since I do believe it preserves muscle while slowly chipping away at fat. TZ is like a fat torching grenade. It will blow up fat and everything else that gets into the way.
 
I think initially it ticked up a bit, but now its back down into the 60s with no issues. I have had no sides at all (other than the initial nausea from TZ). That went away after a few weeks. When I switched to Reta I had no sides, but the hunger did come back. So I still stand by my belief that TZ is better for cutting fat FAST whereas Reta is prob better for most bodybuilders since I do believe it preserves muscle while slowly chipping away at fat. TZ is like a fat torching grenade. It will blow up fat and everything else that gets into the way.
Good take. Although it could also be that we simply need more Reta than we need Tirz mg per mg. I haven’t used Tirz personally so I don’t have first hand experience, but I think a lot of people wrongly assume the dosages are supposed to be equivalent.
 
I’ve been on Retatrutide for 11 weeks now and I definitely have a reduced waist size. My shorts are slightly looser all of a sudden. My weight is slightly less than when I started. Strength is the same.

I decided I’m going with 2mg per week for the time being (1mg 2x per week).
 
I’ve been on Retatrutide for 11 weeks now and I definitely have a reduced waist size. My shorts are slightly looser all of a sudden. My weight is slightly less than when I started. Strength is the same.

I decided I’m going with 2mg per week for the time being (1mg 2x per week).
Ok but the question is whether there were any changes in the diet, amount of cardio etc. or you just added reta and didn't change anything at all
 
Ok but the question is whether there were any changes in the diet, amount of cardio etc. or you just added reta and didn't change anything at all
Yes that’s a good question and I should have mentioned those details.

Diet is mostly the same but I will admit I have eaten slightly fewer cheat meals as a result of the mild appetite suppression. My normal bodybuilding diet otherwise is unchanged. I’m eating roughly about 3800k calories per day if I do an average for the week, which is probably only slightly less.

Cardio is the same as always. I have always been very good about doing it. Training is the same as well.

Anabolics are 500mg test PW, 200mg deca PW, 12.5mg anavar ED, and 2.3iu HGH ED. I was on this for months prior to adding Retatrutide, so nothing changed here either.

Reta dose ranged between 2-3mg per week.
 
Ok but the question is whether there were any changes in the diet, amount of cardio etc. or you just added reta and didn't change anything at all

For me, this argument is like what came first, the chicken or the egg. I lost a shit ton of fat using TZ. Did I change my diet? Yeah, I had to since I had zero appetite. But it would not have happened if not for the TZ. For example: If I were to say I took 1 gram of deca per week and my chest grew one inch in circumference. The question would be, did you change your workout? I might say, it's the same workout but instead of using 225x10 on the incline press I am now using 275x10. The argument would be, "well your chest grew because you are pressing 50lbs more on the incline press...had nothing to do with the drugs." Believe me, these GLP drugs make a huge difference.
 
For me, this argument is like what came first, the chicken or the egg. I lost a shit ton of fat using TZ. Did I change my diet? Yeah, I had to since I had zero appetite. But it would not have happened if not for the TZ. For example: If I were to say I took 1 gram of deca per week and my chest grew one inch in circumference. The question would be, did you change your workout? I might say, it's the same workout but instead of using 225x10 on the incline press I am now using 275x10. The argument would be, "well your chest grew because you are pressing 50lbs more on the incline press...had nothing to do with the drugs." Believe me, these GLP drugs make a huge difference.
He's probably asking because some have claimed to lose weight without changing diet.
 
Yes that’s a good question and I should have mentioned those details.

Diet is mostly the same but I will admit I have eaten slightly fewer cheat meals as a result of the mild appetite suppression. My normal bodybuilding diet otherwise is unchanged. I’m eating roughly about 3800k calories per day if I do an average for the week, which is probably only slightly less.

Cardio is the same as always. I have always been very good about doing it. Training is the same as well.

Anabolics are 500mg test PW, 200mg deca PW, 12.5mg anavar ED, and 2.3iu HGH ED. I was on this for months prior to adding Retatrutide, so nothing changed here either.

Reta dose ranged between 2-3mg per week.
He's probably asking because some have claimed to lose weight without changing diet.
that's what I'm aiming for - glp doesn't give anything for people like me because it doesn't matter if I'm really hungry after eating too much, if I want to do cardio or not, I still stick to the plan 100% without the slightest deviation, so for me their main effect is to reduce appetite, which is the biggest problem for most people, the reason they don't get results - because their psyche simply doesn't allow them not to cheat and they constantly snack on something
 
that's what I'm aiming for - glp doesn't give anything for people like me because it doesn't matter if I'm really hungry after eating too much, if I want to do cardio or not, I still stick to the plan 100% without the slightest deviation, so for me their main effect is to reduce appetite, which is the biggest problem for most people, the reason they don't get results - because their psyche simply doesn't allow them not to cheat and they constantly snack on something
That’s nice, but not everyone is as military as you when it comes to dieting. So why not let the rest of us enjoy it in peace without having to have this thread bashed every time something positive is said about GLP-1? This used to be a really enjoyable thread, but now it feels like every time something good comes up, you come in and shut it down. Just my two cents.
 
That’s nice, but not everyone is as military as you when it comes to dieting. So why not let the rest of us enjoy it in peace without having to have this thread bashed every time something positive is said about GLP-1? This used to be a really enjoyable thread, but now it feels like every time something good comes up, you come in and shut it down. Just my two cents.
man you misunderstand me - I have nothing against GLP but I am trying to understand the real way they work and so far from what I gather from what people are documenting everything indicates that whether it is the effect on easier weight loss or inflammation reduction, positive effect on lipids etc. it simply comes from reduced appetite and therefore reduced food and shit food so they are good for the general population but not for bodybuilders who follow the plan regardless - for them it can only give negatives in the form of worsening/slowing down digestion and a huge amount of complications that will come with the huge amounts of food that a competitive bodybuilder has to consume even when cutting
 
man you misunderstand me - I have nothing against GLP but I am trying to understand the real way they work and so far from what I gather from what people are documenting everything indicates that whether it is the effect on easier weight loss or inflammation reduction, positive effect on lipids etc. it simply comes from reduced appetite and therefore reduced food and shit food so they are good for the general population but not for bodybuilders who follow the plan regardless - for them it can only give negatives in the form of worsening/slowing down digestion and a huge amount of complications that will come with the huge amounts of food that a competitive bodybuilder has to consume even when cutting
Look, I’m not trying to debate or convince you of anything, and this will be my last reply. Just want to point out that there’s more to Retatrutide than just appetite suppression.

It has direct effects beyond just making you eat less, including:

  • Increased Energy Expenditure – It’s been shown to enhance calorie burn, not just reduce intake.
  • Improved Insulin Sensitivity – Helps regulate blood sugar and improve metabolic health, even in non-diabetics.
  • Direct Impact on Fat Metabolism – Affects fat oxidation and lipid profiles independently of diet.
  • Lower Systemic Inflammation – Reduces inflammatory markers, which has benefits beyond weight loss.
  • Muscle Preservation – There’s evidence suggesting it helps preserve lean mass while cutting.
And just to be clear, this isn’t some "bro science" take—this is based on actual pharmaceutical studies from companies that spend billions researching this, not just anecdotal reports. That’s all I wanted to say, take it or leave it.
 
Look, I’m not trying to debate or convince you of anything, and this will be my last reply. Just want to point out that there’s more to Retatrutide than just appetite suppression.

It has direct effects beyond just making you eat less, including:

  • Increased Energy Expenditure – It’s been shown to enhance calorie burn, not just reduce intake.
  • Improved Insulin Sensitivity – Helps regulate blood sugar and improve metabolic health, even in non-diabetics.
  • Direct Impact on Fat Metabolism – Affects fat oxidation and lipid profiles independently of diet.
  • Lower Systemic Inflammation – Reduces inflammatory markers, which has benefits beyond weight loss.
  • Muscle Preservation – There’s evidence suggesting it helps preserve lean mass while cutting.
And just to be clear, this isn’t some "bro science" take—this is based on actual pharmaceutical studies from companies that spend billions researching this, not just anecdotal reports. That’s all I wanted to say, take it or leave it.
I don't know why you still think I have something against it - and as for the arguments you listed, in my opinion it's not the result of the drug itself but the effect it has on our appetite, thus changing people's eating habits - I always ask if the only change was adding GLP or if you also changed your lifestyle/nutrition - the answer is 100% "I started eating less and cheating less on my diet because I don't have cravings"

And as for scientific research on drugs, I never believed in them completely because today we know very well that pharmaceutical concerns finance these studies themselves and they are biased in their favor - always
 

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