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RU-58841 systemic effects on muscle gain

QxG

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May 10, 2025
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So I’m looking for some anecdotal reports on if people have experienced significant muscle gain while using RU-58841 and I’m curious if anyone is familiar with the science of it’s systemic effects. I know it metabolizes into a weak anti androgen that has a very short half life in the blood, but am unsure of what happens when the compound itself goes systemic. Ofcourse the scientific discourse on this is limited because it’s pharmaceutical trials were ended, that’s why I’m looking for some anecdotal reports. From what I understand, it will go systemic to some degree, which means there is the chance of it binding to androgen receptors in muscles, which of course, at that point it would not matter how many anabolics you have in your system if they can’t bind to the receptors. I’ve been using it successfully during my cut to maintain hair, however, I’m becoming a bit skeptical if I should use it during a bulk.
 
I used it for 4+ years straight at 50-75 mgs everyday

I never experienced any side effects, and while I never looked like Lee Priest, I'd blame genetics more than RU for that lol

I stopped using it because finasteride was cheaper ($2 a month with insurance) and had more clinical data. And recently buzzed my hair down anyways...didn't feel like spending $50+ for a haircut lol
 
I used it for 4+ years straight at 50-75 mgs everyday

I never experienced any side effects, and while I never looked like Lee Priest, I'd blame genetics more than RU for that lol

I stopped using it because finasteride was cheaper ($2 a month with insurance) and had more clinical data. And recently buzzed my hair down anyways...didn't feel like spending $50+ for a haircut lol
Same experience here. We are splitting hairs with the integration of ru58841 and inhibition of muscle growth.
 
So I’m looking for some anecdotal reports on if people have experienced significant muscle gain while using RU-58841 and I’m curious if anyone is familiar with the science of it’s systemic effects. I know it metabolizes into a weak anti androgen that has a very short half life in the blood, but am unsure of what happens when the compound itself goes systemic. Ofcourse the scientific discourse on this is limited because it’s pharmaceutical trials were ended, that’s why I’m looking for some anecdotal reports. From what I understand, it will go systemic to some degree, which means there is the chance of it binding to androgen receptors in muscles, which of course, at that point it would not matter how many anabolics you have in your system if they can’t bind to the receptors. I’ve been using it successfully during my cut to maintain hair, however, I’m becoming a bit skeptical if I should use it during a bulk.
I wouldn't worry about it, as the amount of RU58841 that does goes systemic is going to be so miniscule, that it simply won't affect enough androgen receptors to have any meaningful effect. Besides, even if the entire dose did go systemic (which won't happen), it still wouldn't come anywhere close to binding all your AR's; not even close.

Bottom line: I think you're going to be OK using RU58841 on your bulks. :)
 
I used it for 4+ years straight at 50-75 mgs everyday

I never experienced any side effects, and while I never looked like Lee Priest, I'd blame genetics more than RU for that lol

I stopped using it because finasteride was cheaper ($2 a month with insurance) and had more clinical data. And recently buzzed my hair down anyways...didn't feel like spending $50+ for a haircut lol
orally? sorry for bump but noticed you mentioned a certain mg doseage.
 

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