Saturated receptors

[STEVO 47]

I was reading through one of my old boards I belonged to and
came across the subject of reseptors being saturated by long
use of AAS. Um, I don't believe in this for reasons, but wanted to
find out why our gains slow through out long cycles. It was stated
that the rise in SHBG in the blood during the cycle will bind to
the AAS which will lessin the effectivness and in turn stop all gains.
Is this just theory. Anyone with an input.

 

[STEVO 47]

Again, Anyone?

 

[Larry Bowie]

raised cortisol levels may be a factor too ????

maybe take cortisol blockers/inhibitors

 

[STEVO 47]

I know that proviron and aromasin are good for lowering shbg
but cortisol blockers

 

[STEVO 47]

Did some research and from what I read AAS will block cortisol
receptors. confused. I'm not the brightest bulb on this but this
is something new to me. Anymopre info. would be appreciated.

 

[KillerStack]

Um, I don't believe in this for reasons, but wanted to
find out why our gains slow through out long cycles. It was stated
that the rise in SHBG in the blood during the cycle will bind to
the AAS which will lessin the effectivness and in turn stop all gains.
Is this just theory. Anyone with an input.

Yea the gains will slow even if the drugs work as well as ever. Otherwise you'd gain ad infinitum. Nothing keeps working at the same rate infinitely. When gains stop basically you'll have to increase dosage and/or add drugs that work through other mechanisms such as insulin or GH. The receptor being "saturated" is not why gains slow or stop IMO. The receptors have very short half-lives, they don't get "dirty" and probably don't downregulate to a significant degree although there is some debate regarding that.

The SHBG thing is a total myth. SHBG is LOWERED in a dose dependant manner with AAS administration. Estrogen from aromatizing gear will raise SHBG but the androgen will override that effect.

 

[STEVO 47]

So the SHBG things a myth. And ya I don't believe in receptor theory
either. And I know there's alot of debate on that too. Appreciate
getting with me on this KS, Clears up some questions I've had for a
while.