I used Syntherol on my calves for a couple months and it works but as Elvia said it takes quite a bit of volume to get results there. I don't know if I would do it again; it's time consuming (for a muscle like calve), expensive, and you really have to like needles a lot. LOL.
I'm getting good results on my calves now just by working them hard, and with AAS/gh. I think that maybe with a little more real muscle on them I might be tempted to give Syntherol a go again.