- Joined
- Aug 30, 2011
- Messages
- 20
Taken from Suppversity:
"Sildenafil 2.0? As of now the drug does not even have a proper name, but TPN729MA could still be the "next Viagra".
Contrary to viagra which fails to increase the maximal intracavernous pressure (ICP; without going into too much embarrassing details here, the package of a supplement would probably refer to this as "harder than steel", or somewhat like that TPN729MA increased both the peak ICP and ICP/BP ratio.
In a rodent model the 5mg dosage of TPN729MA worked within <15min (+80% ICP/blood pressure, at that point in time sildenafil 2.5mg achieved only a 20% increase) and lasted for the whole study period of 120min. With +150% ICP/BP at 120minutes and the values being steadily increasing, this could yet eventually be a little excessive SuppVersity - Nutrition and Exercise Science for Everyone
Reference: Wang, Z., Zhu, D., Yang, X., Li, J., Jiang, X., Tian, G., Terrett, N. K., Jin, J., Wu, H., He, Q., Yang, B. and Shen, J. (2013), The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. Journal of Sexual Medicine."
---Has anyone else heard about this?
"Sildenafil 2.0? As of now the drug does not even have a proper name, but TPN729MA could still be the "next Viagra".
Contrary to viagra which fails to increase the maximal intracavernous pressure (ICP; without going into too much embarrassing details here, the package of a supplement would probably refer to this as "harder than steel", or somewhat like that TPN729MA increased both the peak ICP and ICP/BP ratio.
In a rodent model the 5mg dosage of TPN729MA worked within <15min (+80% ICP/blood pressure, at that point in time sildenafil 2.5mg achieved only a 20% increase) and lasted for the whole study period of 120min. With +150% ICP/BP at 120minutes and the values being steadily increasing, this could yet eventually be a little excessive SuppVersity - Nutrition and Exercise Science for Everyone
Reference: Wang, Z., Zhu, D., Yang, X., Li, J., Jiang, X., Tian, G., Terrett, N. K., Jin, J., Wu, H., He, Q., Yang, B. and Shen, J. (2013), The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. Journal of Sexual Medicine."
---Has anyone else heard about this?