Some MGF info.. BBB

[bigbaldbulldog]

here is a interesting read on MGF..

**broken link removed**

 

[bigbaldbulldog]

BBB. PhD,MD..?

once again everything i have been saying is stated in this finding.. BBB knows what he is saying even though i do not have a PhD,MD after my name..

Combined with other items MGF works better and more effectively(sp)

 

[PHIL HERNON]

BBB.....

once again everything i have been saying is stated in this finding.. BBB knows what he is saying even though i do not have a PhD,MD after my name..

Combined with other items MGF works better and more effectively(sp)

What have you been saying that this article says????

 

[bigbaldbulldog]

What have you been saying that this article says????

"Therefore the role of IGF-1 splice variants including MGF seem to be very relevent"

"HGH" is known to upregulate the IGF-1 gene"

"MGF plays a duel role in muscle growth and repair"

I stated in my other post that i thought it was best to take:
HGH
IGF-1
MGF
test
Insulin

All in respectable, smart and low doses to get the best effect but i was ousted and called out saying that was not wise and made no sense and to me it makes all the sense in the world..

If you drive a car across the country from NY to LA and you had all your fluids at 1/2 levels and your gas at 87 octane you would putt your way across and you would make it there well and alive and healthy.. but lets take that same car and put
1 qt to much oil in
top off the radiator fluid and overfill coolant tank
and use 93 octane all the way

What kind of shape will the engine be in if it ran at 110%+ the whole trip? Over worked
Over stressed
Over used

you simply can not do that to your body you ned to go slow and steady anything that comes fast goes fast.. your body will reject the new growth as an intrusion and infection and do what it has to to get rid of it as soon as it can any way it can

 

[PHIL HERNON]

BUT

THAT ARTICLE SAYS NOTHING ABOUT TEST, SLIN, AND GH IN COMBINATION.

 

[bigbaldbulldog]

not in the words you want to see but i sttand by my theory...

 

[PHIL HERNON]

BBB, POLEASE DONT TAKE THIS AS AN ATTACK

not in the words you want to see but i sttand by my theory...

BUT THAT ARTICLE SAYS NOTHING OF WHAT YOU HAVE BEEN SAYING.

 

[PHIL HERNON]

NOW.....

IF THESE ARE JUST YOUR THEORYS, THEN JUST SAY SO. I WILL UNDERSTAND BETTER WHERE YOU ARE COMING FROM.

 

[bigbaldbulldog]

here it is in science talk:

okay guys muscle satellite cells are mononuclear cells that remain in a quiescent state until activated when they proliferate and fuse with muscle fibres to donate nuclei, a process necessary for post-embryonic growth, hypertrophy and tissue repair in this post-mitotic tissue. Now these processes have been associated with expression of the insulin-like growth factor (IGF-I) gene that can undergo alternative splicing to generate different gene products with varying functions.

Now in order for us at professional muscle to gain insight into the cellular mechanisms involved in local tissue repair, the time courses of expression of two IGF-I splice variants produced in muscle were determined together with marker genes for satellite cell activation following local muscle damage. Using real-time RT-PCR with specific primers, the mRNA transcripts in rat tibialis anterior muscles were measured at different time intervals following either mechanical damage imposed by electrical stimulation of the stretched muscle or damage caused by injection with bupivacaine.

Now here is the best part guys...ready hold on it was found that the autocrine splice variant mechano growth factor (MGF) was rapidly expressed and then declined within a few days following both types of damage. Systemic IGF-IEa was more slowly upregulated and its increase was commensurate with the rate of decline in MGF expression. Satellite cell activation as measured by M-cadherin and one of the muscle regulatory factors MyoD and the sequence of expression suggests that the initial pulse of MGF is responsible for satellite cell activation, as the systemic IGF-IEa mRNA expression peaks after the expression of these markers, including M-cadherin protein. Later splicing of the IGF-I gene away from MGF but towards IGF-IEa seems physiologically appropriate as IGF-IEa is the main source of mature IGF-I for upregulation of protein synthesis required to complete the repair.

This shows us that IGF and MGF must be present to work effectively and that many things takes place at a very basic level and if that is the case very basic elements must be present such as HGH, MGF,IGF,hormone(test), insulin and amino acids..ect.......

 

[PHIL HERNON]

AGAIN.......

here it is in science talk:

okay guys muscle satellite cells are mononuclear cells that remain in a quiescent state until activated when they proliferate and fuse with muscle fibres to donate nuclei, a process necessary for post-embryonic growth, hypertrophy and tissue repair in this post-mitotic tissue. Now these processes have been associated with expression of the insulin-like growth factor (IGF-I) gene that can undergo alternative splicing to generate different gene products with varying functions.

Now in order for us at professional muscle to gain insight into the cellular mechanisms involved in local tissue repair, the time courses of expression of two IGF-I splice variants produced in muscle were determined together with marker genes for satellite cell activation following local muscle damage. Using real-time RT-PCR with specific primers, the mRNA transcripts in rat tibialis anterior muscles were measured at different time intervals following either mechanical damage imposed by electrical stimulation of the stretched muscle or damage caused by injection with bupivacaine.

Now here is the best part guys...ready hold on it was found that the autocrine splice variant mechano growth factor (MGF) was rapidly expressed and then declined within a few days following both types of damage. Systemic IGF-IEa was more slowly upregulated and its increase was commensurate with the rate of decline in MGF expression. Satellite cell activation as measured by M-cadherin and one of the muscle regulatory factors MyoD and the sequence of expression suggests that the initial pulse of MGF is responsible for satellite cell activation, as the systemic IGF-IEa mRNA expression peaks after the expression of these markers, including M-cadherin protein. Later splicing of the IGF-I gene away from MGF but towards IGF-IEa seems physiologically appropriate as IGF-IEa is the main source of mature IGF-I for upregulation of protein synthesis required to complete the repair.

This shows us that IGF and MGF must be present to work effectively and that many things takes place at a very basic level and if that is the case very basic elements must be present such as HGH, MGF,IGF,hormone(test), insulin and amino acids..ect.......

WE ALREADY HAVE BEEN OVER AND OVER AND OVER THE FIRST THREE PARAGRAPHS. YOU ARE JUST STATING IT IN DIFFERENT WAYS. WHAT I WANT TO KNOW IS WHERE IS THE RESEARCH ON YOUR LAST PARAGRAPH? WHERE DOES IT SAY THAT INJECTING THESE SUBSTANCES OVER ENDOGENOUS PRODUCTION IS A BENEFIT, AND AT WHAT DOSAGES? IS THIS WHERE YOUR THEORY COMES INTO PLAY?

 

[PHIL HERNON]

A FEW MORE QUESTIONS

WHAT IS A "quiescent state"?

WHAT IS "bupivacaine"?

WHAT IS AN "M-cadherin"?

 

[tarbaby2000]

quiescent basically means asleep
bupivacaine is an local anaesthetic used alot for long dental procedures or in surgery. It lasts quite a long time and seems to work well for those that have a high tolerance or dont normally respond to local anaesthetics. It really wont cause any significant tissue damage, so maybe the article just means the damage cause by injection. So maybe if we just stick ourselves many many times our bodies will just naturally overexpress these growth factors.
I dont know what M-cadherin protein is.

 

[LakeMountD]

Bupivacaine is a myotoxin they use in that study just to cause damage to the area so they could see how the body responded to it.

BBB- That article you are quoting from has a slight bit of misleading info in it. That study was done before they realized that MGF plays the "proliferating" role and IGF-1Ea is more of the "differentiating" role. The newest study by Goldspink states that MGF does not cause any differentiation (activation) of satellite cells which is why both compounds are so important together.

The information you provided in the first post is all elementary info bro, and no I am not trying to be condescending or disprespectful, I am just saying. The hGH axis is very well known. hGH enters the liver and signals for hIGF-1 gene production and there are many variants. hIGF-1Ea, which is liver,systemic type and hIGF-1Ec (aka MGF and in rats is actually IGF-1Eb), which is a localized form that does not bind to the hIGF-1Ea receptor. Decrease hGH production and you decrease the amount of all the growth factors following it, which is why I have been advocating this is the reason people aren't seeing outstanding gains past 3-4 weeks.

I have taken LR3 before and the thing I realized most, is although I stopped seeing decent gains after 3-4 weeks, I still had the same extreme hunger pangs and some other effects that LR3 IGF-1 exhibits, which tells me downregulation can't be the only cause here, and another factor must be. MGF inhibition due to hGH inhibition is what I feel one of the biggest culprits is. However, human experimentation is the only way to truly find out.

 

[bigbaldbulldog]

The article i used was basic and elementary but in order for soem of the guys reading and understanding they need to know why from square one..

no offense taking...

The info can be misleading if you hinge your hat on it solely and should be used to gather more info and compare...ultimately the best source of how to use and when to use will come from those of us who jump in and experiment and play with it and see what works best...

WE NEED TO BE THE LAB RATS

 

[LakeMountD]

The article i used was basic and elementary but in order for soem of the guys reading and understanding they need to know why from square one..

no offense taking...

The info can be misleading if you hinge your hat on it solely and should be used to gather more info and compare...ultimately the best source of how to use and when to use will come from those of us who jump in and experiment and play with it and see what works best...

WE NEED TO BE THE LAB RATS

I've stated this many times.

 

[bigbaldbulldog]

I've stated this many times.

and as you and i will continue to say...

If we gave the same exact drugs , diet and training program to 100 guys you would get 100 different results... You need to find what works for you and that changes every few years so you better know how to read your body and know what it is telling you all the time

 

[PHIL HERNON]

BBB

and as you and i will continue to say...

If we gave the same exact drugs , diet and training program to 100 guys you would get 100 different results... You need to find what works for you and that changes every few years so you better know how to read your body and know what it is telling you all the time

I WOULD PLACE MORE EMPHASIS ON DIET AND TRAINING THAN YOU DO THE DRUGS. I THINK YOU RELY ON THEM TOO MUCH, THAT MIGHT BE YOUR PROBLEM. IF ITS ALL ABOUT DRUGS ALL THE TIME THEN EASY COME EASY GO, YOU KNOW WHAT I AM SAYING?

 

[bigbaldbulldog]

Hi Buddy

I WOULD PLACE MORE EMPHASIS ON DIET AND TRAINING THAN YOU DO THE DRUGS. I THINK YOU RELY ON THEM TOO MUCH, THAT MIGHT BE YOUR PROBLEM. IF ITS ALL ABOUT DRUGS ALL THE TIME THEN EASY COME EASY GO, YOU KNOW WHAT I AM SAYING?

I had tried for years with drugs diet and training to get over 200lbs and could not... you came along and said get off the drugs take these supplements revamped my training and said here is your diet broken down by ratios...

I gained weight and lost body fat and within 6 months i went from 195 to 218lbs drug free ... drugs are not the answer to this problem but if you have your
rest
training
diet
supplements
all in order when you do take some items watch out your gonan grow big fast and strong quickly...IMO

Thanks again for showing me the drugs are more a problem then an answer

 

[PHIL HERNON]

I AGREE

I had tried for years with drugs diet and training to get over 200lbs and could not... you came along and said get off the drugs take these supplements revamped my training and said here is your diet broken down by ratios...

I gained weight and lost body fat and within 6 months i went from 195 to 218lbs drug free ... drugs are not the answer to this problem but if you have your
rest
training
diet
supplements
all in order when you do take some items watch out your gonan grow big fast and strong quickly...IMO

Thanks again for showing me the drugs are more a problem then an answer

THATS TRUE

 

[LakeMountD]

So hard to argue diet/training/supps with an ex-IFBB pro :st:r-wars <---him <----me