Some people need to learn the hard way that more does not always = better.
A friend of mine put it best: Your body has its "sweet spot" at whatever dosage that may be, say 350-500mg. That's where everything is spot on and running efficiently in terms of recovery, low/zero side effects, estrogen balance, good mood, improved sleep quality etc etc, what further benefit could there be to running a dosage 2-4x higher than what your body is comfortable running at, without disrupting that balance and having to take more drugs to try balance out the side effects when it starts showing signs of stress and maladaptation?
My lab rat had to learn the hard way. But being ignorant and fueled by ego, learning the hard way was at the very least, humbling, and probably the best and only way to learn to not do stupid things like that again.
Upon reflecting on my lab rats fuckery during its time of stupidity, the way I see it now:
At higher dosages, above that which the body is not comfortable with, the body shifts its focus from utilizing the compound for recovery, repair and running optimally, to trying to either get rid of the excess, trying keep itself alive whilst the compound wreaks havoc on your insides, or at the very least tries and find a balance.
For my lab rat, none of those effects are favorable to long term health or achieved more muscle mass or benefits which a low dosage could not provide.
Sure, in theory there will be more muscle mass and everything else that comes along with high(er) dosages. But realistically, the benefits of higher dosages are equally paired with the side effects, weather they be internal or external, short term or long term.
Less is more, But the quantity of "less" is relative to the individual as I've found out.