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Increase HDL by 28% and lowers LDL by 115%. Also showed kidney protective effects.
Biomarkers. 2020 Mar 12:1-9. doi: 10.1080/1354750X.2020.1737734. [Epub ahead of print]
Protective effect of rosemary (Rosmarinus officinalis) against diethylnitrosamine-induced renal injury in rats.
Hassanen NHM1, Fahmi A2, Shams-Eldin E1, Abdur-Rahman M2.
Author information
1Special Food and Nutrition Department, Food Technology Research Institute, Agriculture Research Center, Giza, Egypt.2Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.
Abstract
Context: The kidney plays a central role in detoxification and excretion of toxic metabolites, and therefore, is susceptible to toxicity by xenobiotics.Objective: To investigate the protective effect of Rosmarinus officinalis (rosemary) powder and its essential (volatile) oil against diethylnitrosamine (DEN)-induced renal injury in rats.Materials and methods: Phenolic and flavonoid components were characterised in rosemary powder using HPLC-UV instrument while rosemary essential oil (E.O) was investigated via GC-MS technique. In rat model, rosemary was administrated orally (in diet) for two months. Lipid profile, antioxidant biomarkers, kidney functions and histopathological examinations were assessed.Results: Hesperidin (4878.88 ppm) and ellagic acid (403.57 ppm) are among the major phenolic and flavonoid constituents in rosemary powder. Camphor (18.36%) and α-pinene (12.74%) represent the main E.O active ingredients. Rats treated with rosemary E.O showed a significant elevation in serum HDL (28.28%) accompanied by a decrease in LDL (115.47%). A significant decrease in serum creatinine and urea was also reported (69.72 and 109.89%, respectively). Moreover, serum glutathione peroxidise (GSH-Px) activity has been significantly increased. Kidney histopathological examinations confirmed the protective effect against DEN-induced abnormalities.Conclusion: Rosemary (powder/E.O) was able to reduce or even prevent the severity of diethylnitrosamine-induced renal dysfunction.
KEYWORDS:
Diethylnitrosamine; GSH-Px; cholesterol; kidney function; rosemary essential oil; total antioxidant
PMID: 32118487 DOI: 10.1080/1354750X.2020.1737734
Source: https://www.ncbi.nlm.nih.gov/pubmed/32118487
Biomarkers. 2020 Mar 12:1-9. doi: 10.1080/1354750X.2020.1737734. [Epub ahead of print]
Protective effect of rosemary (Rosmarinus officinalis) against diethylnitrosamine-induced renal injury in rats.
Hassanen NHM1, Fahmi A2, Shams-Eldin E1, Abdur-Rahman M2.
Author information
1Special Food and Nutrition Department, Food Technology Research Institute, Agriculture Research Center, Giza, Egypt.2Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.
Abstract
Context: The kidney plays a central role in detoxification and excretion of toxic metabolites, and therefore, is susceptible to toxicity by xenobiotics.Objective: To investigate the protective effect of Rosmarinus officinalis (rosemary) powder and its essential (volatile) oil against diethylnitrosamine (DEN)-induced renal injury in rats.Materials and methods: Phenolic and flavonoid components were characterised in rosemary powder using HPLC-UV instrument while rosemary essential oil (E.O) was investigated via GC-MS technique. In rat model, rosemary was administrated orally (in diet) for two months. Lipid profile, antioxidant biomarkers, kidney functions and histopathological examinations were assessed.Results: Hesperidin (4878.88 ppm) and ellagic acid (403.57 ppm) are among the major phenolic and flavonoid constituents in rosemary powder. Camphor (18.36%) and α-pinene (12.74%) represent the main E.O active ingredients. Rats treated with rosemary E.O showed a significant elevation in serum HDL (28.28%) accompanied by a decrease in LDL (115.47%). A significant decrease in serum creatinine and urea was also reported (69.72 and 109.89%, respectively). Moreover, serum glutathione peroxidise (GSH-Px) activity has been significantly increased. Kidney histopathological examinations confirmed the protective effect against DEN-induced abnormalities.Conclusion: Rosemary (powder/E.O) was able to reduce or even prevent the severity of diethylnitrosamine-induced renal dysfunction.
KEYWORDS:
Diethylnitrosamine; GSH-Px; cholesterol; kidney function; rosemary essential oil; total antioxidant
PMID: 32118487 DOI: 10.1080/1354750X.2020.1737734
Source: https://www.ncbi.nlm.nih.gov/pubmed/32118487