Stumped on this trt induced gyno, bloodwork advice?

[npcout]

Back in my competing days, would run all sorts of stuff, test at a gram, etc. now that I’m on doc prescribed trt at 120mg/wk, adex 0.5mg/wk. I’ve had a gyno flare up in one nipple.

I split my test and adex m-w-f

TT: 1300ish
Estrodiol: 28

I feel good, I’m fairly lean, visible 6 pack. Workout, daily cardio, eat clean for the most part.

It’s unilateral and a hard pea sized or slightly larger firm mass, that is sensitive and painful. Slight tenderness on other size but no mass. I took a 4 week course of tamoxifen with no response. I don’t want to bump adex up and crash Estrodiol.

Any labs or suggestions? Doubtful a prolactin issue. Progesterone? Thanks

 

[hogan87]

Any GH in the mix now? Anything besides test? igf1 #`s?

 

[specter]

Back in my competing days, would run all sorts of stuff, test at a gram, etc. now that I’m on doc prescribed trt at 120mg/wk, adex 0.5mg/wk. I’ve had a gyno flare up in one nipple.

I split my test and adex m-w-f

TT: 1300ish
Estrodiol: 28

I feel good, I’m fairly lean, visible 6 pack. Workout, daily cardio, eat clean for the most part.

It’s unilateral and a hard pea sized or slightly larger firm mass, that is sensitive and painful. Slight tenderness on other size but no mass. I took a 4 week course of tamoxifen with no response. I don’t want to bump adex up and crash Estrodiol.

Any labs or suggestions? Doubtful a prolactin issue. Progesterone? Thanks

Tamoxifen also works for progesterone, only real option here is get it fixed at the doc.

 

[npcout]

Any GH in the mix now? Anything besides test? igf1 #`s?

No, just test for a long while

 

[npcout]

Tamoxifen also works for progesterone, only real option here is get it fixed at the doc.

I would think I should be able to calm it down though, via meds. It’s very angry so to say. Gyno flare ups on real cycles i could get under control, and the pain would subside

 

[hogan87]

Very strange since your E2 is only 28. You could try a prolactin test. Maybe you have a tumor on pituitary or something crazy?

 

[cuz]

Back in my competing days, would run all sorts of stuff, test at a gram, etc. now that I’m on doc prescribed trt at 120mg/wk, adex 0.5mg/wk. I’ve had a gyno flare up in one nipple.

I split my test and adex m-w-f

TT: 1300ish
Estrodiol: 28

I feel good, I’m fairly lean, visible 6 pack. Workout, daily cardio, eat clean for the most part.

It’s unilateral and a hard pea sized or slightly larger firm mass, that is sensitive and painful. Slight tenderness on other size but no mass. I took a 4 week course of tamoxifen with no response. I don’t want to bump adex up and crash Estrodiol.

Any labs or suggestions? Doubtful a prolactin issue. Progesterone? Thanks

I'm in the same boat but my TRT is 150mg a week. I've tried to control it with exemestane and nolvadex. Neither helps. Having bloods drawn tomorrow to test estradiol, progesterone, and testosterone.

 

[npcout]

Very strange since your E2 is only 28. You could try a prolactin test. Maybe you have a tumor on pituitary or something crazy?

It doesn’t feel like prolactin induced gyno that you get from deca. I use to live off npp so I am familiar. Estro vs prolactin based gyno are very different, this aligns more closely with Estro but I appreciate your words.

 

[A50#]

I just had a similar conversation with some people about TRT and gyno/estrogen issues a few days ago. How about bodyfat? Has that increased any? Sometimes the higher the BF the worse issues like this are for some.

It doesn’t feel like prolactin induced gyno that you get from deca. I use to live off npp so I am familiar. Estro vs prolactin based gyno are very different, this aligns more closely with Estro but I appreciate your words.

 

[Fa Seeshus]

Have you had full thyroid labs? I was getting it due to being hypothyroid and having elevated prolactin.

 

[caps83]

When this happened, your estrogen levels were probably higher when it flared up and now it's lower on labs but the area has not resolved. You might want to get an estradiol sensitive if the previous test was just a standard one. Could also be related to any other meds you might be taking. Sometimes these take a little time to resolve. Try to avoid feeling it to see if it's still there, this will make it worse. Raloxifene will work better than tamoxifen for gyno. Def take a baby aspirin and nattokinase if you take SERMs like tamox or raloxifene

 

[Mufasa123]

You are getting good answers above but reality is that normal causes/pathways have been covered. Go ahead and get more bloods to see what you find but in the meantime I'd schedule a Dr's appt and get it on the calendar.

 

[npcout]

I just had a similar conversation with some people about TRT and gyno/estrogen issues a few days ago. How about bodyfat? Has that increased any? Sometimes the higher the BF the worse issues like this are for some.

Bodyfat is only lower if anything. I’m around 12% at this point in my life.

 

[npcout]

Have you had full thyroid labs? I was getting it due to being hypothyroid and having elevated prolactin.

Last full thyroid panel was 6 months ago, all was good. Tsh and reverse t3 were well in range.

 

[npcout]

When this happened, your estrogen levels were probably higher when it flared up and now it's lower on labs but the area has not resolved. You might want to get an estradiol sensitive if the previous test was just a standard one. Could also be related to any other meds you might be taking. Sometimes these take a little time to resolve. Try to avoid feeling it to see if it's still there, this will make it worse. Raloxifene will work better than tamoxifen for gyno. Def take a baby aspirin and nattokinase if you take SERMs like tamox or raloxifene

So, that is what I’ve been reading. My
Estro was a sensitive test. But apparently what I’ve learned, you can have low normal Estrodiol, but have a high aromatase in breast tissue that is not detectable on blood work.

Started tamoxifen as I have some on hand, will be getting Ralox and will switch over. See what happens in 4-8 weeks.

Your theory holds true, when I spoke to my doc about it. My test dose got bumped up, Estro went into the 50s nip flared, adex dose increased 8+ weeks of Estro in the 20-30s has been good, but nip hasn’t resolved. Angry little fucker needs to chill out with a serm.

Can’t even remember what I use to do when I competed and used tons of shit, likely over did it. Was always gyno prone.

 

[Fa Seeshus]

Has anyone tried Super Raloxifene? I might give that a go when back in stock.

 

[npcout]

Has anyone tried Super Raloxifene? I might give that a go when back in stock.

That’s been out forever. Just got Ralox, never used. Always use tamox in the past when I competed always had it on hand. Never thought I’d need it on 100-120mg test cyp, but then again 120mg test cyp from cvs puts my total test at 1700, that’s about what ugl did at 400-500.

 

[graybass]

I had the same thing. Used to do stupid amounts of everything and never had a problem. Cut back to TRT levels and had bad flair up on both sides. I'm older, been mostly on for 30 years! Cut back and boom! nipples killing me! Asked a super knowledgeable trainer gym owner. He said as we get older sometimes it seems like it just catches up with you. He had surgery! So I quit everything for like 6 months and it went away. Recently started TRT levels again and Wham back in a couple weeks. Being super careful micro dosing EOD and still a little painful. Yikes I really want to up it a little but, probably not smart!

 

[npcout]

I had the same thing. Used to do stupid amounts of everything and never had a problem. Cut back to TRT levels and had bad flair up on both sides. I'm older, been mostly on for 30 years! Cut back and boom! nipples killing me! Asked a super knowledgeable trainer gym owner. He said as we get older sometimes it seems like it just catches up with you. He had surgery! So I quit everything for like 6 months and it went away. Recently started TRT levels again and Wham back in a couple weeks. Being super careful micro dosing EOD and still a little painful. Yikes I really want to up it a little but, probably not smart!

That makes sense. I’m def aging but staying young. Idk if pharma test from CVS is damn potent, but 120mg now, does what 500 of ugl did back in the day. Not talking about one source in particular, I was using multiple sources here on pm back in the day.

 

[Alzadosghost]

Have you tried simply backing off that dose. Your older? Simply might be too much testosterone for you. And it’s highly likely. Most sides are dose related and I’m sure you know this it sounds like you have been at this a while right? Tamoxifen can work for prolactin but if that breast tissue is even slightly developed it won’t change it. And it never managed prolactin or estrogen for really at all. I’d say letro but the rebound from that can make it all worse if your body does not like it.