Sumaglutide starting dose

[UsmcOldSchoolMuscle]

Start with .25/week and stay there until the food noise kicks in hard again. Up to .5/week and do the same. Minimum effective dosage is the game

Thanks bro

 

[NorwegianMuscle]

My dentist is doing this at 0.25mg dose once a week with a prescription. When I visited her she was on her 4th week. She said she always feels full, bloated, or constipated and eats very little. I bought 2 vials to try out.

 

[Freedom69!]

I’ve tried both Sema and Tirz. Tirz all day everyday IMO. Sema gave me and the wife terrible gastro sides (bloating, constipation, nausea) and we never made it over 0.5mg a week. I will say that both absolutely do exactly as intended but Tirz seems like a background drug quietly working. The only thing I got from Tirz was random constipation which was always contributed to a lack of consistent water consumption. Quickly remedied by hydration and some form of natural food based bump in Fiber.

Both IMO are going to cause fatigue just due to the fact that your calories become significantly reduced. It’s actually rather mind blowing how they work at such a low dose. 2.5 mg a week of Tirz will seem like nothing is happening until you realize your portions are getting smaller and smaller by the day and look in the mirror about 3 or 4 weeks later.

 

[KingOfSushi]

Anyone familiar with possible lingering Gastroparesis post usage?

 

[KingOfSushi]

So, like, my buddy totally messed up the starting dose 'cause he put the decimal in the wrong spot, and man, he felt awful for days afterward.

I sort of accidentally did this. Shot 1.5mg cause I thought it was my gh… was actually my wife’s sema. Feeling like shit right now indeed. Gastric reflux out the ass and can’t shit.

 

[KingOfSushi]

If you go cold turkey you will be hungrier far beyond anything you've ever experienced.

I sure hope so, I’m trying to grow right now

 

[Neuro1234]

My experience is on the medical side, long time ICU nurse here, not on the user side. It can be wicked on the GI tract. It delays gastric emptying pretty severely, you have to stop taking three weeks prior to anesthesia because they are finding this is how long it can delay. Cases of food fermenting in the gut. Lots of small bowel obstructions and even cases of permanent colostomy pouches. In my opinion if you’re going to use it, lowest effective dosing is best practice.

 

[KingOfSushi]

It delays gastric emptying pretty severely, you have to stop taking three weeks prior to anesthesia because they are finding this is how long it can delay. Cases of food fermenting in the gut. Lots of small bowel obstructions and even cases of permanent colostomy pouches.

This is my concern after my mishap unfortunately. Hoping the symptoms stop soon.

 

[Neuro1234]

This is my concern after my mishap unfortunately. Hoping the symptoms stop soon.

It’s mine too, for you. Hydrate hydrate. Keep me posted, happy to share my thoughts when I can.

 

[KingOfSushi]

It’s mine too, for you. Hydrate hydrate. Keep me posted, happy to share my thoughts when I can.

I only took one dose, but it was 1.5mg. The acid reflux SUCKS

 

[Neuro1234]

I only took one dose, but it was 1.5mg. The acid reflux SUCKS

Yeahhhhh elimination half life of 7 days I think? You’re in it now buddy. How long ago did you take it?

 

[KingOfSushi]

Yeahhhhh elimination half life of 7 days I think? You’re in it now buddy. How long ago did you take it?

Like 2-3 days? So probs peaking rn

Hoping I’ll be good after the weekend

 

[Neuro1234]

Like 2-3 days? So probs peaking rn

Hoping I’ll be good after the weekend

I hope so too!

 

[KingOfSushi]

I hope so too!

Well, at least I know one thing now; this stuff is insanely effective

 

[jl9987]

I was on 0.5mg sema x 3 a week cos tirz wasn’t doing much for appetite and my appetite is still crazy. Fml. Don’t really wanna go higher than 1.5mg a week either cos as ppl mentioned the delayed gastric emptying can be quite severe and sometimes almost makes me want to take something just to move my bowels quicker as can be uncomfortable

 

[marssel]

I will tell you for me, tirzepatide, is ordered almost 2 to 1 now that the initial Sema burst hit the scene and was the only name people knew

 

[Cv215]

My gf lost like 35lbs using semaglutide from a peptide company. Price was like 95-115 a bottle. Cant remember exactly.

Ill tell you what. She started at .25 omce a week and she pretty much threw up for 2 or 3 weeks straight. The first week was her in this constant state of throwing up.

her and her boss both used it and she didnt want to be a quiter so she pushed through it and after a few weeks the nauseau went away.

She described the sides as both a form of nauseau that was gradual and would last a while, and then what she referred to as instant vomit syndrome. She would go from not being nauseaus at all to within a fraction of a second just blowing chunks out of no where.

 

[Sectør]

I think you already received some good answers on the starting dose/ramp up dosing scheme, so I'll just say that I've found tirz much more effective (and with less sides than sema)

Not saying sema isn't effective. It's highly effective, and i didn't really get any sides from it aside from some occasional light headedness when standing up (I'm assuming it's a low blood sugar issue)

But from my understanding tirzepatide has additional functionality and biomechnics that semaglutide doesn't provide

Courtesy of Google AI:
"Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that acts on both receptors to treat type 2 diabetes and obesity:

GIP receptor
Tirzepatide activates the GIP receptor, which stimulates insulin secretion during meals.

GLP-1 receptor
Tirzepatide activates the GLP-1 receptor, which is expressed in brain regions that regulate food intake. "

 

[bigbumpkin2003]

My lady is running for her second time. We know from experience she can not handle a whole 100 mgs. It’s too much. She stair steps up to 75 mgs which is her max. Typical protocol…25 mgs first week ,50 mgs second week, and finally 75 mgs and she runs that till end of cycle . She goes to one she’s cramping so bad she can’t even hold down water for two days. It was bad eventually she had to go to ER for a bag of saline and nausea medicine. Took 5 days before she was one solid food again .

 

[Jefe]

This is my concern after my mishap unfortunately. Hoping the symptoms stop soon.

You’ll feel like ass for 5 days, then moving back in the right direction for 2 days, then “normal.”

I too made the gh mistake. A mistake you only make once. Good thing I take baby gh dose. Sema is buried in the back of the fridge now.