The fatigue disappears because exercise cranks up stimulatory neurotransmitters. As for the delay, my guess is many ramp up the doses over a period instead of starting at say 30mg/day. The sedation/fatigue seems dose dependent. I've taken SD at 10mg/day with no fatigue.finally a substantive discussion...I came up with a theory while reading threads about SD and I wanted it to be confronted with the experience and knowledge of others, because I want to solve the "mystery of SD lethargy" to AVOID lethargy before I take SD because I already have symptoms that resemble chronic fatigue.
Sure, that (almost?) every AAS causes a decrease in cortisol, because the test itself does that. Sure, that (almost?) every AAS increases insulin sensitivity, because the test itself does that. But there is a difference between low cortisol/glucose levels and VERY LOW levels, I will not explain why now. For example, test and every other AAS increase inflammation, but only 1-test is known to significantly increase CRP. As for the effect of AAS on neurotransmitters, test increases the effect of noradrenaline (anxiety, heartbeat, nervousness) and these symptoms often occur with primo, EQ, sten or tren; in addition, excess estrogen increases prolactin, a dopamine inhibitor, hence less motivation to exercise and general laziness. In addition, 600mg/w of the test turned out to be worse in terms of libido than 300mg/w, probably due to the increase in prolactin that eliminates the stimulating androgenic effects of the test. Tren lethargy may result from poor sleep, because only phases of deep sleep regenerate the brain.
How can we explain the fact that fatigue disappears during training? Besides, such a strong GABA-nergic effect would have to be immediate, and not after 2-3 weeks, tolerance built after a few weeks of daily use, and after a cycle a rebound effect, typical for depressants
All of this is speculation of course. I have just never been convinced of the "liver toxicity" claim.